DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and CG4950

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	152/736 - (20%)
Similarity:	257/736 - (34%)	Gaps:	213/736 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RIVLELALLVLGVISSCRAVNCPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPVEHLDLSGNKF 66
            |.:||:.::::..||||.......|.||.
  Fly     5 RRILEVIVILILAISSCDGSGGDIPLRCD------------------------------------ 33

  Fly    67 LEFPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFKYAPSL 131
                    :.||:.|:|::..:.      |:.|||...               |.|...|..|.
  Fly    34 --------EYDSMGYMDVNEAFC------TVTGFTVTH---------------SQNVVIKNIPP- 68

  Fly   132 KRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQI 196
                         ||...|.....|:|..:..           .:....|
  Fly    69 -------------GNMVKFMKFYESTLLYMPF-----------HLFETFP--------------- 94

  Fly   197 AALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRN--TELQFDSLSEDPILTYMLRKLDV 259
                  .|:.||:||.:|..|:.....|..||..|||:.|  |.:|....    |...:|.:||:
  Fly    95 ------YLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVF----IGANVLMRLDL 149

  Fly   260 SYCNLDSIELS---GLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAFAKLK 321
            ||..:.|:.::   ||..::::.|.||||:.:..:.|.:|..||.|....|:|..|..:.|..::
  Fly   150 SYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMR 214

  Fly   322 RLKELNLA-----------FNEIARLD---------RNF-IRNNDVLVELNLSRNVLQKLTKIVS 365
            |:||:||:           |.:.|.|:         :|| :...:::.:|:|..|.|..||   .
  Fly   215 RIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIVHQLHLDNNYLTNLT---I 276

  Fly   366 NSVRTINMSWCEITSIESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVRNN 430
            |:.|.:..|..:|:.:   .|.....|:.||||.|.::.:........:..|::::..:..:..:
  Fly   277 NATRFVRASHNQISEL---FLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNPIGPLNIS 338

  Fly   431 TFREFPELADLHLNGNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVD-FYDYLTAKPA 494
            ||.:...|..|:|.|..:.. :....|...|:|::|.|..|..     :.|.:| |..|||....
  Fly   339 TFSQLKRLRGLNLRGTGIRE-LKFGMFSKQKYLEELDLSFNNL-----TILNLDMFVPYLTNLKK 397

  Fly   495 KIKDRNHLRCAAPAVFYGKLWEFACADVWILNARTSSTGEKAWSIIMLTLLGLGALVLGYACLQK 559
            .:.|.|.|                          |...|.:.:|.....|..||.....:.|  .
  Fly   398 FLIDGNGL--------------------------TELQGNRTFSEAFPQLQKLGVSRNRFNC--S 434

  Fly   560 YLRKRKVRQS-------DREYEENDDELRRIRDLNERILREEATPSLQHTQEISLLPSYEDALRM 617
            ||....:..|       :.|.:.|.||...|||::          .:..:||:.......:..::
  Fly   435 YLHHLLIPPSLPESVVLNIEPDTNLDETPHIRDVS----------CISQSQEVVNASFTAEESKL 489

  Fly   618 PKLVRPVKSMMDLSGPERARNSRKLRRSQTHADGDGSQSEAEDGLQLDSRQRFRSVEMLSNRDKE 682
            ...::.:...:|:.|.........|...|..|...|       ||.|.......::..|.|   :
  Fly   490 ESQIQMLSKQLDIVGSHSKNLELHLAFMQIFAYVMG-------GLVLVGVVSLITLRYLKN---Q 544

  Fly   683 RTAQYG----PYRRTGYMEYN 699
            |:.:|.    .:|....||.|
  Fly   545 RSGRYDRSSIVFRSNATMEAN 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	0/21 (0%)
		LRR_RI	<58..236	CDD:238064	31/177 (18%)
		LRR_8	78..141	CDD:290566	11/62 (18%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		leucine-rich repeat	103..130	CDD:275380	3/26 (12%)
		leucine-rich repeat	131..155	CDD:275380	3/23 (13%)
		LRR_8	156..214	CDD:290566	8/57 (14%)
		leucine-rich repeat	158..182	CDD:275380	1/23 (4%)
		LRR_8	202..285	CDD:290566	28/87 (32%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		leucine-rich repeat	254..274	CDD:275380	8/22 (36%)
		LRR_8	273..333	CDD:290566	20/70 (29%)
		leucine-rich repeat	275..298	CDD:275380	7/22 (32%)
		LRR_RI	277..>471	CDD:238064	53/214 (25%)
		leucine-rich repeat	299..322	CDD:275380	7/22 (32%)
		LRR_8	321..402	CDD:290566	27/101 (27%)
		leucine-rich repeat	323..346	CDD:275380	9/43 (21%)
		leucine-rich repeat	347..391	CDD:275380	11/43 (26%)
		leucine-rich repeat	392..413	CDD:275380	6/20 (30%)
		LRR_8	393..448	CDD:290566	12/54 (22%)
		leucine-rich repeat	414..437	CDD:275380	3/22 (14%)
		LRRCT	471..517	CDD:214507	10/46 (22%)
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	8/22 (36%)
		LRR_8	118..178	CDD:290566	20/63 (32%)
		leucine-rich repeat	120..143	CDD:275380	8/26 (31%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		LRR_8	192..250	CDD:290566	15/57 (26%)
		leucine-rich repeat	192..215	CDD:275380	7/22 (32%)
		LRR_RI	<207..432	CDD:238064	56/262 (21%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		leucine-rich repeat	240..299	CDD:275380	14/64 (22%)
		LRR_8	299..356	CDD:290566	13/56 (23%)
		leucine-rich repeat	300..321	CDD:275380	6/20 (30%)
		leucine-rich repeat	322..345	CDD:275380	3/22 (14%)
		LRR_8	344..405	CDD:290566	18/66 (27%)
		leucine-rich repeat	346..365	CDD:275380	4/19 (21%)
		leucine-rich repeat	370..394	CDD:275380	9/28 (32%)
		leucine-rich repeat	395..420	CDD:275380	6/50 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100