DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and caps

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	873	Identity:	177/873 - (20%)
Similarity:	293/873 - (33%)	Gaps:	266/873 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IVLELALLVLGVISSCRAVNCPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPVEHLDLSGNKFL 67
            :||....:.||:      .|||..|.|.  .|:|..:|...:|...|......::.|.:..||..
  Fly    29 LVLATLPVALGL------ANCPNGCECD--DDTLMVNCGEGTLDVLPIALNPAIQRLVIKNNKLK 85

  Fly    68 EFPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFKYAPSLK 132
            ...:.......|.:||||.|.:.:|                            |..:|.|...|:
  Fly    86 TIDSSMQFYAQLTFLDLSFNDMLTI----------------------------PERSFAYHAKLQ 122

  Fly   133 RLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQI- 196
            .|.||.|::|...|           .|.||||:..:                 |||..|.:|::
  Fly   123 ELHLDHNKIGQVSN-----------KTFLGLSTISV-----------------LNLRGNLIAELE 159

  Fly   197 --AALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNT------ELQFDSLSEDPILTYM 253
              ...|...|..|:|....|.::....||.:.||..|.|..||      ||.|.:|       :.
  Fly   160 YRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQAL-------HS 217

  Fly   254 LRKLDV---SYCNLDSIELSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQD 315
            |.:|.:   |:..:.......|..||.:.|:|..|..:..:.......|..:|||.|.|..|...
  Fly   218 LAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTA 282

  Fly   316 AFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCEITS 380
            ||.:|.||::||:..|:...:..........|..|.|:.  .|:|.:
  Fly   283 AFQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTG--AQRLRR------------------ 327

  Fly   381 IESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVRNNTFREFPELADLHLNG 445
            :||.|.|..:.::.|:||:|              :|||    .|:::   .....|.|:.:.|..
  Fly   328 VESGAFSGNTNLEHLNLSSN--------------KQLN----ELSSI---ALGGLPHLSTVVLKA 371

  Fly   446 NRLTS----PIPPNYFDGNKFLDQLWLGDNPWICDCH----SPLFV------DFYDYLTAKPAKI 496
            |:|:|    .:|  :.|    |..|.|.:||:.|||.    ..|.|      .:...:.|.|..:
  Fly   372 NQLSSLDEGLVP--WAD----LQTLDLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTAL 430

  Fly   497 KDRNHLRCAAPAVFYGKLWEFACADVWILNARTSSTGEKAWSIIMLTLLGLGALVLGYACLQKYL 561
            :|......|.|                :|.....:..::|  ||.:.::...||:...| |..|.
  Fly   431 RDLPLAHLAEP----------------LLGCAHGAASKQA--IIGILVVACAALITTLA-LVLYT 476

  Fly   562 RKRKVRQ----------SDREYEENDDELRRIRDLNERILREEATPSLQHTQEISLLPSYEDALR 616
            .:.::|:          .:|||::...:                                |:.:.
  Fly   477 CRHRIREMLKGHSALGRKEREYQKTFSD--------------------------------EEYMS 509

  Fly   617 MPKL----VRPVKSMMDLSGPERARNSRKLRRSQTHAD-----------GDGSQSEAEDGLQ--- 663
            .|..    |.|...    ..|..|.|||.:..::...:           |.|..|.|...:|
  Fly   510 RPPPGGGGVHPAAG----GYPYIAGNSRMIPVTELXLEAPPPPQLRGRGGGGGASTASGAVQQLQ 570

  Fly   664 --------LDSRQRFRSVEMLSNRDKERTAQYGPYRRTGYMEYNQSGSRRF-----------SIE 709
                    .:|..:...:..::|..:::.||  ..:.|..|.::|...|..           |:.
  Fly   571 VPSAVDQASNSFAQLSHIHYMTNNGQQQQAQ--QQQSTSKMHHSQQDMRLLACNGGKPLNATSLP 633

  Fly   710 DSRFPAAHLKT-----QNLQSAEQI--GNFQSYENSPYTKRKPKIAEIPPFKRVNMMADSVEFLT 767
            ..|.|.....|     |.|.:..::  .:|...:|..:.:...           .:.|...:.::
  Fly   634 RHRPPVVQESTLSHYSQPLANGIRLTQDHFNHNQNQSHNQHYG-----------GVYAKPCDAMS 687

  Fly   768 DPEYDEVGSKHGSPFAKRKPKPPVLPPP 795
            :|.|....|.:..|.....|..|...||
  Fly   688 EPGYIHNNSHYSLPLDHDLPPSPTPTPP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	3/21 (14%)
		LRR_RI	<58..236	CDD:238064	41/180 (23%)
		LRR_8	78..141	CDD:290566	15/62 (24%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		leucine-rich repeat	103..130	CDD:275380	3/26 (12%)
		leucine-rich repeat	131..155	CDD:275380	7/23 (30%)
		LRR_8	156..214	CDD:290566	14/60 (23%)
		leucine-rich repeat	158..182	CDD:275380	5/23 (22%)
		LRR_8	202..285	CDD:290566	24/91 (26%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	254..274	CDD:275380	4/22 (18%)
		LRR_8	273..333	CDD:290566	20/59 (34%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		LRR_RI	277..>471	CDD:238064	46/197 (23%)
		leucine-rich repeat	299..322	CDD:275380	10/22 (45%)
		LRR_8	321..402	CDD:290566	18/80 (23%)
		leucine-rich repeat	323..346	CDD:275380	4/22 (18%)
		leucine-rich repeat	347..391	CDD:275380	9/43 (21%)
		leucine-rich repeat	392..413	CDD:275380	4/20 (20%)
		LRR_8	393..448	CDD:290566	12/54 (22%)
		leucine-rich repeat	414..437	CDD:275380	4/22 (18%)
		LRRCT	471..517	CDD:214507	12/55 (22%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	3/20 (15%)
		LRR_8	96..155	CDD:290566	26/114 (23%)
		leucine-rich repeat	97..120	CDD:275380	10/50 (20%)
		leucine-rich repeat	121..144	CDD:275380	11/33 (33%)
		LRR_8	143..201	CDD:290566	17/74 (23%)
		leucine-rich repeat	145..168	CDD:275380	6/39 (15%)
		LRR_RI	147..397	CDD:238064	75/320 (23%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..217	CDD:275380	9/30 (30%)
		LRR_8	217..276	CDD:290566	14/58 (24%)
		leucine-rich repeat	218..241	CDD:275380	4/22 (18%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		LRR_8	265..321	CDD:290566	18/55 (33%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	4/22 (18%)
		LRR_8	312..374	CDD:290566	21/102 (21%)
		leucine-rich repeat	314..335	CDD:275380	8/40 (20%)
		leucine-rich repeat	339..363	CDD:275380	8/44 (18%)
		LRRCT	395..445	CDD:214507	13/65 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010