DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and Gp150

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	179/847 - (21%)
Similarity:	313/847 - (36%)	Gaps:	242/847 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VNCPWPCRCTWVVDS-LYADCSRRSLQTYPNFDGIPVEHLDLSGNKFLEFPTLYADIDSLIYLDL 84
            |.||..|:|...|:| |.|.|||                ||:...||      .:||..|:..::
  Fly   256 VPCPRFCQCARNVNSYLVATCSR----------------LDMGIQKF------GSDITDLVVTNV 298

  Fly    85 SSNYISSIGAKTL--IGFTSLRTLLLANNSIDSWESLSPNEAFK-----YAPSLKRLGLD----- 137
            ...|...:|....  :|..::.::.:||.:::...:    |||.     ||.:|..:||.
  Fly   299 GPKYPILMGPNFFQNLGLKNVASIKIANCTLEYLHA----EAFHGLNELYAVNLTDVGLAIINPD 359

  Fly   138 ---GNR----LGSFGNGES-----FELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLAN 190
               ||:    |...||..|     ..||.|||:.:|..|...:..: ..:..:.|.|:..:||:.
  Fly   360 TFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMEL-NPKAFSHLSNVVYINLSQ 423

  Fly   191 NQLAQIAALPSRT------LRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNT---ELQFDSLSE 246
            |.|.:   ||.:.      |..||||..|:..|.....:. ..|..|:|..||   :|.|.
  Fly   424 NSLKK---LPEKAFEKVTLLEELDLSYNSLTELPRDIFNG-TTLSILHLKYNTFNGDLHFG---- 480

  Fly   247 DPILTYMLRKLDVSYCNLDSIELS---GLPQLTEVRLQGN--------------LLRVVDVN--- 291
                |..|::||:|:.::..:..|   .:|.||.:.|:||              .||.:|::
  Fly   481 ----TKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSIND 541

  Fly   292 -------TFANNSMLEVV----------------------------DLSQNVLRHIGQDAFAKLK 321
                   .|..||.|:|:                            |:|...:..:|..||:.:.
  Fly   542 LDQISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMP 606

  Fly   322 RLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCEITSIESTAL 386
            .|..|.||:|.|..|.|........|::|:||.|::.::..:       |.|...|:|
  Fly   607 HLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDL-------IFMDNGELT------- 657

  Fly   387 SSLSVIQKLDLSNNLITDMPT--FMRSETLQQLNLANCRLTTVRNNT-----FREFPELADLHLN 444
                   ||.|:.|.|:.:..  |:....|:.|::.:|.|||:.::.     ::.|..|...:.:
  Fly   658 -------KLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNAS 715

  Fly   445 GNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVDFYDYLTAK----PAKIKDRNHLRCA 505
            || |...|........|.|..|.:.:||..|   :|.|.:|..|:|.:    |.::....:|...
  Fly   716 GN-LIKKISSEDVKSFKNLRSLDITNNPLKC---TPDFQEFISYVTLQMQMTPKRLPVLANLEDD 776

  Fly   506 APAVFYGKLWEFACADVWILNARTSSTGEKAWSIIMLTLLGLGALVLGYACLQKYLRKRKVRQSD 570
            |..|                  :..:..:..||       .|...|..:|.....|.::|...::
  Fly   777 ATIV------------------QLETLAQAGWS-------SLAHEVCKHAEGSDLLDEKKADSAE 816

  Fly   571 REYEE---------NDDELRRIRDLNERILREEATPSLQHTQEISLLPSYEDALRMPKLVRPVKS 626
            .:.|:         |:||.:.:..|::.:|.:....|:|...:.|:
  Fly   817 AKLEKRLKESVKKLNEDEAKLLSVLDKSVLDKSRLSSMQKIMKGSV------------------- 862

  Fly   627 MMDLSGPERARNSRKLRRSQTHADGDGSQSEAEDGLQLDSRQRFRSVEMLSNRDKERTAQYGPYR 691
            ..:.:.||...:...|.......:.|.|..::|:....|...     :...|.|.:|..:.....
  Fly   863 NTETAKPEEDADEENLNNGGEDKEDDSSDYDSEEDDDDDDED-----DDDDNNDDDRFEEAKKNA 922

  Fly   692 RTGYMEYNQSGSRRFSIEDSRFPAAHLKTQNLQS--------------AEQIG-NFQSYENSPYT 741
            :.     ....::.|....::.....|||..:|:              .|::| :.:|.|:..||
  Fly   923 KA-----KADANKAFDTFVNKELKPVLKTDGIQAEEVDMSQETRDKFLLEKLGFDSESEESDEYT 982

  Fly   742 KR 743
            ::
  Fly   983 EK 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	6/21 (29%)
		LRR_RI	<58..236	CDD:238064	51/207 (25%)
		LRR_8	78..141	CDD:290566	16/81 (20%)
		leucine-rich repeat	79..102	CDD:275380	4/24 (17%)
		leucine-rich repeat	103..130	CDD:275380	7/31 (23%)
		leucine-rich repeat	131..155	CDD:275380	11/40 (28%)
		LRR_8	156..214	CDD:290566	17/63 (27%)
		leucine-rich repeat	158..182	CDD:275380	3/23 (13%)
		LRR_8	202..285	CDD:290566	26/108 (24%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	254..274	CDD:275380	5/22 (23%)
		LRR_8	273..333	CDD:290566	24/111 (22%)
		leucine-rich repeat	275..298	CDD:275380	10/46 (22%)
		LRR_RI	277..>471	CDD:238064	54/252 (21%)
		leucine-rich repeat	299..322	CDD:275380	7/50 (14%)
		LRR_8	321..402	CDD:290566	21/80 (26%)
		leucine-rich repeat	323..346	CDD:275380	8/22 (36%)
		leucine-rich repeat	347..391	CDD:275380	9/43 (21%)
		leucine-rich repeat	392..413	CDD:275380	6/22 (27%)
		LRR_8	393..448	CDD:290566	16/61 (26%)
		leucine-rich repeat	414..437	CDD:275380	7/27 (26%)
		LRRCT	471..517	CDD:214507	12/49 (24%)
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	15/63 (24%)
		leucine-rich repeat	343..366	CDD:275380	7/22 (32%)
		leucine-rich repeat	367..391	CDD:275380	7/23 (30%)
		LRR_RI	<374..619	CDD:238064	62/257 (24%)
		LRR_8	390..450	CDD:290566	17/63 (27%)
		leucine-rich repeat	393..415	CDD:275380	3/22 (14%)
		leucine-rich repeat	416..439	CDD:275380	6/25 (24%)
		leucine-rich repeat	440..483	CDD:275380	15/51 (29%)
		leucine-rich repeat	463..481	CDD:275380	7/25 (28%)
		LRR_8	484..542	CDD:290566	14/57 (25%)
		leucine-rich repeat	484..507	CDD:275380	5/22 (23%)
		leucine-rich repeat	508..531	CDD:275380	5/22 (23%)
		leucine-rich repeat	532..569	CDD:275380	8/36 (22%)
		leucine-rich repeat	556..583	CDD:275380	2/26 (8%)
		leucine-rich repeat	570..607	CDD:275380	5/36 (14%)
		LRR_RI	<586..745	CDD:238064	45/180 (25%)
		LRR_8	606..666	CDD:290566	21/80 (26%)
		leucine-rich repeat	608..631	CDD:275380	8/22 (36%)
		leucine-rich repeat	632..655	CDD:275380	7/29 (24%)
		leucine-rich repeat	656..674	CDD:275380	6/31 (19%)
		leucine-rich repeat	733..745	CDD:275378	4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010