DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and 18w

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	137/555 - (24%)
Similarity:	216/555 - (38%)	Gaps:	148/555 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GIPVEHLDLSGNKFLEFPTLY--ADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDS 115
            |..::.||:|.|:....|..:  :.:..|..|.|..|.||::....|.|.:|||.|.::.|.:.|
  Fly   209 GSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVS 273

  Fly   116 WESLSPNEAFKYAPSLKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQ- 179
                .|:|||.....|:.|.|.||.|.....|....|   ..|..|.||        |:|:.:.
  Fly   274 ----LPSEAFAGNKELRELHLQGNDLYELPKGLLHRL---EQLLVLDLS--------GNQLTSHH 323

  Fly   180 --------LPNLERLNLANNQLAQIAALPSRT------LRVLDLSNCSIKNL-SGFFLDAMQNLE 229
                    |..|..|||:||.|.:|.   |:|      |::||:.|.||.:: .|.|| .:.||.
  Fly   324 VDNSTFAGLIRLIVLNLSNNALTRIG---SKTFKELYFLQILDMRNNSIGHIEEGAFL-PLYNLH 384

  Fly   230 ALNLSRNTELQFDSLSEDPILTYMLRKLDVSYCNLDSIELSGLPQLTEVRLQGNLLRVVDVNTFA 294
            .|||:.|                   :|.    .||:...:||..||::.|..||:.:|:...|.
  Fly   385 TLNLAEN-------------------RLH----TLDNRIFNGLYVLTKLTLNNNLVSIVESQAFR 426

  Fly   295 NNSMLEVVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQK 359
            |.|.|:.:|||.|.|..: .:|...|..||.|:|..|:|:....|..||.:.|..|.|..|.:..
  Fly   427 NCSDLKELDLSSNQLTEV-PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGN 490

  Fly   360 LT-------------KIVSNSVRTI---------------------------------------- 371
            :|             .:..|.:::|
  Fly   491 ITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLS 555

  Fly   372 --------------NMSWCEITSIESTALSSLSVIQK------LDLSNNLITDMPTFMRSETLQQ 416
                          |:.|.:|......||.:...:|:      ||.|:|.||::.......:::.
  Fly   556 ENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIEL 620

  Fly   417 LNLANCRLTTVRNNTFREFPELADLHLNGNRLT---------SPIPPNYFDGNKFLDQLWLGDNP 472
            |.:.|..:..::.|||.:...||.:.|..|.|:         :|:     ...|.:.:.:||.||
  Fly   621 LFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPV-----SAEKPVPEFYLGGNP 680

  Fly   473 WICDCHSPLFVDFYDYLTAKPAKIKDRNHLRCAAP 507
            :.|||.........:..|.:...:.|..::.|..|
  Fly   681 FECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	5/23 (22%)
		LRR_RI	<58..236	CDD:238064	62/195 (32%)
		LRR_8	78..141	CDD:290566	23/62 (37%)
		leucine-rich repeat	79..102	CDD:275380	8/22 (36%)
		leucine-rich repeat	103..130	CDD:275380	9/26 (35%)
		leucine-rich repeat	131..155	CDD:275380	8/23 (35%)
		LRR_8	156..214	CDD:290566	21/72 (29%)
		leucine-rich repeat	158..182	CDD:275380	7/32 (22%)
		LRR_8	202..285	CDD:290566	25/89 (28%)
		leucine-rich repeat	204..227	CDD:275380	9/23 (39%)
		leucine-rich repeat	254..274	CDD:275380	5/19 (26%)
		LRR_8	273..333	CDD:290566	22/59 (37%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR_RI	277..>471	CDD:238064	57/275 (21%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR_8	321..402	CDD:290566	26/153 (17%)
		leucine-rich repeat	323..346	CDD:275380	9/22 (41%)
		leucine-rich repeat	347..391	CDD:275380	12/110 (11%)
		leucine-rich repeat	392..413	CDD:275380	7/26 (27%)
		LRR_8	393..448	CDD:290566	16/60 (27%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
		LRRCT	471..517	CDD:214507	9/37 (24%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	90/296 (30%)
		leucine-rich repeat	212..236	CDD:275380	5/23 (22%)
		LRR_8	235..295	CDD:290566	23/63 (37%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	9/26 (35%)
		LRR_8	283..345	CDD:290566	21/72 (29%)
		leucine-rich repeat	285..308	CDD:275380	8/25 (32%)
		leucine-rich repeat	309..334	CDD:275380	7/32 (22%)
		LRR_8	334..393	CDD:290566	25/81 (31%)
		leucine-rich repeat	335..358	CDD:275380	10/25 (40%)
		leucine-rich repeat	359..382	CDD:275380	9/23 (39%)
		LRR_8	382..441	CDD:290566	25/81 (31%)
		leucine-rich repeat	383..406	CDD:275380	10/45 (22%)
		leucine-rich repeat	407..430	CDD:275380	8/22 (36%)
		LRR_8	431..488	CDD:290566	21/57 (37%)
		leucine-rich repeat	431..451	CDD:275380	7/20 (35%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..559	CDD:290566	7/81 (9%)
		leucine-rich repeat	478..499	CDD:275380	5/20 (25%)
		leucine-rich repeat	502..525	CDD:275380	2/22 (9%)
		leucine-rich repeat	526..548	CDD:275380	0/21 (0%)
		leucine-rich repeat	590..617	CDD:275380	7/26 (27%)
		leucine-rich repeat	618..641	CDD:275380	5/22 (23%)
		leucine-rich repeat	642..689	CDD:275380	14/51 (27%)
		LRRCT	679..736	CDD:214507	9/37 (24%)
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010