DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and CG14762

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	131/583 - (22%)
Similarity:	214/583 - (36%)	Gaps:	154/583 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IVLELALLVLGVI---SSCRAVNCP-----WPCRCTWVVDSLYADCSRRSLQTYPNFDG------ 53
            :||.|.:||:..:   ...:...||     .||.||...:.|...|....|.......|
  Fly    16 VVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKS 80

  Fly    54 -----IPVEHLD---LSGNKFLEFPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLAN 110
                 :.:.|.:   |.|..||.....:..|.:.....:..|.:||:||    |.|.|...|...
  Fly    81 PIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGA----GLTQLDVSLNQM 141

  Fly   111 NSIDSWESLSPNEAFKYAPSLKRLGLDGNRL-----GSFGNGESFELLTSSSLTDLGLSSCGISS 170
            .::       |::|.::...|..|.|:.|::     .:|...|:.|:||        |....|:.
  Fly   142 KTV-------PSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILT--------LYENKITQ 191

  Fly   171 IGGDQMVNQLPNLERLNLANNQLAQIAALPSR------TLRVLDLSNCSIKNLSGFFLDAMQNLE 229
            |..:.......:::||||..|.|..|   |.:      ||:.|::....|:.:|....:.:|:|:
  Fly   192 IDPEAFRGLEDHIKRLNLGGNDLTNI---PQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLD 253

  Fly   230 ALNLSRNTELQFDSLSEDPILTYMLRKLDVSYCNLDSIELSGLPQLTEVRLQGNLLRVVDVNTFA 294
            :|.|:.|                |:..:..:.       .|.|..|..:.|:||.:.|:|.:.|.
  Fly   254 SLILAHN----------------MITTVPANV-------FSHLTLLNSLELEGNKISVIDKDAFK 295

  Fly   295 N-NSMLEVVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEIARLDRN-FIRNNDVLVELNLSRNVL 357
            . ...|:.:.|..|.:..|..:|...|.||:.|:|..|.|..|..: |....|.|..|||.:|.:
  Fly   296 GLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDI 360

  Fly   358 QKLTKIV---SNSVRTINMSWCEITSIESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNL 419
            :.|..::   .||:.|:|:...::..|....:.  .||..|.:.:  |||.|          ||
  Fly   361 KVLPSLLFENLNSLETLNLQNNKLQRIPQDIME--PVIDTLRIID--ITDNP----------LN- 410

  Fly   420 ANCRLTTVRNNTFREFPE-LADLHLNGNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFV 483
            .:|.||.        ||: |.||....:.::....|.                     ||..|
  Fly   411 CSCELTW--------FPKLLEDLKNKDDEMSQKKKPL---------------------CHMSL-- 444

  Fly   484 DFYDY-LTAKPAKIKDRNHLRCAAPAVFYGKLWEFACADVWILNARTSSTGEKAWSIIMLTLL 545
            |..:| :.|.|.:     .:.||.                  ||...|.|......|:.:.:|
  Fly   445 DNREYFVQAMPTE-----KMHCAG------------------LNVSPSPTSGGLMRILQVNIL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	6/24 (25%)
		LRR_RI	<58..236	CDD:238064	46/191 (24%)
		LRR_8	78..141	CDD:290566	15/62 (24%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..130	CDD:275380	4/26 (15%)
		leucine-rich repeat	131..155	CDD:275380	8/28 (29%)
		LRR_8	156..214	CDD:290566	14/63 (22%)
		leucine-rich repeat	158..182	CDD:275380	3/23 (13%)
		LRR_8	202..285	CDD:290566	17/88 (19%)
		leucine-rich repeat	204..227	CDD:275380	4/22 (18%)
		leucine-rich repeat	254..274	CDD:275380	2/19 (11%)
		LRR_8	273..333	CDD:290566	18/60 (30%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
		LRR_RI	277..>471	CDD:238064	50/199 (25%)
		leucine-rich repeat	299..322	CDD:275380	6/22 (27%)
		LRR_8	321..402	CDD:290566	23/84 (27%)
		leucine-rich repeat	323..346	CDD:275380	7/23 (30%)
		leucine-rich repeat	347..391	CDD:275380	11/46 (24%)
		leucine-rich repeat	392..413	CDD:275380	6/20 (30%)
		LRR_8	393..448	CDD:290566	15/55 (27%)
		leucine-rich repeat	414..437	CDD:275380	6/22 (27%)
		LRRCT	471..517	CDD:214507	9/46 (20%)
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	81/335 (24%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..154	CDD:275380	5/29 (17%)
		LRR_8	154..214	CDD:290566	17/67 (25%)
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		leucine-rich repeat	179..203	CDD:275380	6/31 (19%)
		leucine-rich repeat	204..227	CDD:275380	8/25 (32%)
		LRR_8	226..286	CDD:290566	17/82 (21%)
		leucine-rich repeat	228..251	CDD:275380	4/22 (18%)
		leucine-rich repeat	252..275	CDD:275380	7/45 (16%)
		LRR_8	276..335	CDD:290566	18/58 (31%)
		leucine-rich repeat	276..300	CDD:275380	7/23 (30%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	18/73 (25%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100