DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5819 and Lingo4

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_796224.1	Gene:	Lingo4 / 320747	MGIID:	2444651	Length:	618	Species:	Mus musculus

Alignment Length:	528	Identity:	139/528 - (26%)
Similarity:	200/528 - (37%)	Gaps:	157/528 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLELALLVLGVISSCRAVNCPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPV--EHLDLSGNKF 66
            :|.|.||..|.|||     ||..|.||....:::  |:.|.|.|.|.  |:|:  |.||||||:.
Mouse    42 LLFLLLLPGGSISS-----CPTVCDCTSQTRAVF--CAHRRLDTIPG--GLPLDTELLDLSGNRL 97

  Fly    67 LEFPT-LYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFKYAPS 130
            ..... :.:.:..|..||||.|.:|                           :|.|. ||....|
Mouse    98 WGLQRGMLSRLGQLQELDLSYNQLS---------------------------TLEPG-AFHGLQS 134

  Fly   131 LKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQ 195
            |..|.|.||||...|.| .|..||:.:|.||.|:...:..   |...::|.:|::|.:.:|.|..
Mouse   135 LLTLRLQGNRLRIVGPG-IFSGLTALTLLDLRLNQIVLFL---DGAFSELGSLQQLEVGDNHLVF 195

  Fly   196 IAALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYMLRKLDVS 260
            :|                    .|.|. .:..|..:.|.|
Mouse   196 VA--------------------PGAFA-GLAKLSTITLER------------------------- 214

  Fly   261 YCNLDSI---ELSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAFAKLKR 322
             |||.::   .|:.||.|..:||:                .|::..|....||.:||
Mouse   215 -CNLSTVPGLALAQLPALVALRLR----------------ELDIERLPAGALRGLGQ-------- 254

  Fly   323 LKELNL-AFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCEITSIESTAL 386
            ||||.: .:..:..||..      .||.||||                ::.::.|.::|:...||
Mouse   255 LKELEIHHWPSLEALDPG------SLVGLNLS----------------SLAITRCNLSSVPFQAL 297

  Fly   387 SSLSVIQKLDLSNNLITDMPTFMRSE--TLQQLNLANCRLTTVRNNTFREFPELADLHLNGNRLT 449
            ..||.::.||||.|.|:.:|....|.  .||:|.|:...||::..:.|........|.:..|.|.
Mouse   298 HHLSFLRILDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQ 362

  Fly   450 SPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVDF---YDYLTAKPAKIKDRNHLRCAAPAVFY 511
            : :....|.....|..|.|..||..|||.....:..   .|:.|:.||         ||.|....
Mouse   363 T-LEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRRLDFGTSPPA---------CAGPQHVQ 417

  Fly   512 GK-LWEFA 518
            || |.||:
Mouse   418 GKSLREFS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	7/24 (29%)
		LRR_RI	<58..236	CDD:238064	45/178 (25%)
		LRR_8	78..141	CDD:290566	17/62 (27%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		leucine-rich repeat	103..130	CDD:275380	4/26 (15%)
		leucine-rich repeat	131..155	CDD:275380	11/23 (48%)
		LRR_8	156..214	CDD:290566	11/57 (19%)
		leucine-rich repeat	158..182	CDD:275380	6/23 (26%)
		LRR_8	202..285	CDD:290566	14/85 (16%)
		leucine-rich repeat	204..227	CDD:275380	2/22 (9%)
		leucine-rich repeat	254..274	CDD:275380	5/22 (23%)
		LRR_8	273..333	CDD:290566	14/60 (23%)
		leucine-rich repeat	275..298	CDD:275380	3/22 (14%)
		LRR_RI	277..>471	CDD:238064	48/196 (24%)
		leucine-rich repeat	299..322	CDD:275380	6/22 (27%)
		LRR_8	321..402	CDD:290566	23/81 (28%)
		leucine-rich repeat	323..346	CDD:275380	6/23 (26%)
		leucine-rich repeat	347..391	CDD:275380	11/43 (26%)
		leucine-rich repeat	392..413	CDD:275380	8/22 (36%)
		LRR_8	393..448	CDD:290566	17/56 (30%)
		leucine-rich repeat	414..437	CDD:275380	7/22 (32%)
		LRRCT	471..517	CDD:214507	15/49 (31%)
Lingo4	NP_796224.1	LRRNT	56..89	CDD:214470	12/36 (33%)
		leucine-rich repeat	69..86	CDD:275380	7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		LRR_8	90..145	CDD:290566	23/82 (28%)
		leucine-rich repeat	111..134	CDD:275380	11/50 (22%)
		LRR_RI	112..345	CDD:238064	86/357 (24%)
		LRR_8	134..193	CDD:290566	22/62 (35%)
		leucine-rich repeat	135..158	CDD:275380	11/23 (48%)
		leucine-rich repeat	159..182	CDD:275380	6/25 (24%)
		LRR_8	182..237	CDD:290566	18/101 (18%)
		leucine-rich repeat	183..206	CDD:275380	7/43 (16%)
		leucine-rich repeat	207..230	CDD:275380	8/48 (17%)
		leucine-rich repeat	231..254	CDD:275380	7/38 (18%)
		leucine-rich repeat	255..302	CDD:275380	17/68 (25%)
		LRR_8	278..334	CDD:290566	21/71 (30%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		LRR_8	326..385	CDD:290566	15/59 (25%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		leucine-rich repeat	351..369	CDD:275380	3/18 (17%)
		leucine-rich repeat	375..387	CDD:275378	5/11 (45%)
		IG_like	445..526	CDD:214653
		Ig	456..526	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930