DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5819 and Nepn

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	XP_006256553.1	Gene:	Nepn / 309775	RGDID:	1307755	Length:	512	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	135/530 - (25%)
Similarity:	226/530 - (42%)	Gaps:	94/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ALLVLGVISSCRAVNCPWPCRCTWVVDSLYADCSRRSLQTYPNFD---GIP------------VE 57
            |.|:...:|:....|||..|.|    |||      :|:|.|...:   |||            ::
  Rat     6 AFLLWLSLSNVLGANCPGRCSC----DSL------QSVQCYRLLEVPSGIPSTTRRLYISHSRIQ 60

  Fly    58 HLDLSGNKFLEFPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPN 122
            ||.||.      .|....::..|.|...:..|.:...|||   |:|:||.|..|.:....|..|
  Rat    61 HLQLSN------LTQLLALEDFILLASGTESIENDTFKTL---TTLKTLELWKNKLRRVPSALP- 115

  Fly   123 EAFKYAPSLKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLN 187
                  .:|:.|.|:.|.:.:. :|..||.|  |:|..|.|.:..|||: ...|::.|.:|:.|.
  Rat   116 ------ANLEVLKLNDNSICAL-HGSDFEGL--SNLKVLELKNNLISSL-SPSMLSSLVSLQSLL 170

  Fly   188 LANNQLAQIA---ALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPI 249
            :..|.:..:.   :||:  |:.:.:....:..:||....::|||:.|:.|.|
  Rat   171 VDGNNIESVTGPLSLPN--LKYMSMEKNKLHLISGNVFTSLQNLQFLSFSGN------------- 220

  Fly   250 LTYMLRKLDVSYCNLDSIELSGLPQ-LTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIG 313
               .|.|:.::           ||: |..::::.|.|:||......:...|..:.||:|:|..|
  Rat   221 ---FLTKIPIN-----------LPKSLLSLKMERNQLKVVRFRDMRHLENLSHLYLSENLLSSI- 270

  Fly   314 QDAFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCE- 377
             |....|..|..|..:.|.:..|..   |....|.:|:.|.|.:|::|......:|.:...:.:
  Rat   271 -DGAQLLTNLTTLEASQNRLQMLPP---RLPSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDN 331

  Fly   378 --ITSIESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVRNNTFREFPELAD 440
              ::..|:.||...|.:..|.|..||:..:|..: .:||.:|:|....:..:.....|:..:|..
  Rat   332 NVVSLFEAGALQKCSQLSNLALEQNLLLSIPLRL-PKTLARLDLKGNAIQDMAERELRDLKQLQV 395

  Fly   441 LHLNGNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVDFYDYLTAKPAKIKDRNHLRCA 505
            |:|..|:: |.:.....:|...|..|:|..|||.|.|.   .:...:.|.||...:|..   :||
  Rat   396 LNLRNNKI-SALDLKALEGLPRLRHLYLDGNPWNCTCS---LLRAREVLKAKGTDVKGG---QCA 453

  Fly   506 APAVFYGKLW 515
            |||...|:.|
  Rat   454 APAERQGESW 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	5/21 (24%)
		LRR_RI	<58..236	CDD:238064	49/180 (27%)
		LRR_8	78..141	CDD:290566	18/62 (29%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..130	CDD:275380	7/26 (27%)
		leucine-rich repeat	131..155	CDD:275380	8/23 (35%)
		LRR_8	156..214	CDD:290566	15/60 (25%)
		leucine-rich repeat	158..182	CDD:275380	8/23 (35%)
		LRR_8	202..285	CDD:290566	15/83 (18%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	254..274	CDD:275380	3/19 (16%)
		LRR_8	273..333	CDD:290566	17/60 (28%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		LRR_RI	277..>471	CDD:238064	47/196 (24%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR_8	321..402	CDD:290566	19/83 (23%)
		leucine-rich repeat	323..346	CDD:275380	5/22 (23%)
		leucine-rich repeat	347..391	CDD:275380	10/46 (22%)
		leucine-rich repeat	392..413	CDD:275380	5/20 (25%)
		LRR_8	393..448	CDD:290566	14/54 (26%)
		leucine-rich repeat	414..437	CDD:275380	4/22 (18%)
		LRRCT	471..517	CDD:214507	16/45 (36%)
Nepn	XP_006256553.1	leucine-rich repeat	50..72	CDD:275380	5/27 (19%)
		leucine-rich repeat	73..96	CDD:275380	6/25 (24%)
		leucine-rich repeat	118..141	CDD:275380	8/25 (32%)
		leucine-rich repeat	142..165	CDD:275380	8/23 (35%)
		leucine-rich repeat	166..187	CDD:275380	4/20 (20%)
		leucine-rich repeat	188..211	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	9/49 (18%)
		leucine-rich repeat	236..256	CDD:275380	4/19 (21%)
		LRR_RI	<251..425	CDD:238064	43/180 (24%)
		leucine-rich repeat	257..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..299	CDD:275380	5/22 (23%)
		LRR_8	298..358	CDD:290566	14/59 (24%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	3/22 (14%)
		leucine-rich repeat	348..371	CDD:275380	7/23 (30%)
		LRR_8	367..426	CDD:290566	14/59 (24%)
		leucine-rich repeat	372..392	CDD:275380	3/19 (16%)
		leucine-rich repeat	393..416	CDD:275380	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243556at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010