DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and lron-15

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_495322.3	Gene:	lron-15 / 174079	WormBaseID:	WBGene00016974	Length:	1275	Species:	Caenorhabditis elegans

Alignment Length:	458	Identity:	122/458 - (26%)
Similarity:	206/458 - (44%)	Gaps:	60/458 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 HLDLSGNKF--LEFPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWE--- 117
            ||:|:|||.  ::...|....|:|:.|.:::||:..|....|.|...|..|.::.|.|.|.:
Worm   386 HLNLNGNKLNRIDGDVLKGCTDTLVELFIANNYLEHIPHGVLSGMKQLEHLDISKNKIMSLKKPT 450

  Fly   118 ---SLSPNEAFKYAPSLKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQ 179
               |::..|    ..:::||.|.|||:.:..:...||.:...:..|:..:.....|   .::..:
Worm   451 SLLSITKEE----TSTVRRLNLAGNRINNMSDYLIFEHMPLLTYVDVSFNRIRFIS---PRVFEK 508

  Fly   180 LPNLERLNLANNQLAQIAAL-PSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRN-----TE 238
            |.|||.|.|.|||||...:| ....||.|.|.|..|:.:..|.|..:..|:.|:|:.|     ||
Worm   509 LKNLESLFLQNNQLAHFPSLFRLDKLRHLMLDNNQIQKIDNFSLADLPKLQHLSLAGNQLDIITE 573

  Fly   239 LQFDSLSEDPILTYMLRKLDVSYCNLDSI---ELSGLPQLTEVRLQGNLLRVVDVNTFANNSMLE 300
            ..|.|.|...     |:.|::::..:.||   ..|.|..|.::||..|.:|.:...||:|...|.
Worm   574 NMFGSSSSSE-----LKSLNLAHNKIHSISSRSFSDLDNLQQLRLSHNNIRTITSMTFSNLRNLR 633

  Fly   301 VVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVS 365
            .:|||.|.:..|...|..:|..|..|:|..|.:..:||:..|:...|..|.||.|..::.:
Worm   634 YLDLSHNRIIKILPSALYQLPALDVLHLDHNNLNEIDRDAFRSFSDLQSLKLSHNAFRRFS---- 694

  Fly   366 NSVRTINMSWCEITSIESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVRNN 430
                      ||.       |.|:|.:.:||||:|.|.::..|..:..:::|:||:..:..:...
Worm   695 ----------CEF-------LGSISQVHQLDLSSNQINEIDIFCIARGIRKLSLASNSVEKINRK 742

  Fly   431 TFREFPELADLHLNGNRLTSPIPPNYFDGNK---------FLDQLWLGDNPWICDCHSPLFVDFY 486
            ..::..||..:.::.|.:.......:.:..|         ::..||.|...:....|: |.:.|.
Worm   743 LLQDATELTSIDISHNGIIDVDSDAFCECRKLSHIKLSHNYIRNLWKGTFQYQESLHT-LDISFN 806

  Fly   487 DYL 489
            |.|
Worm   807 DIL 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	7/21 (33%)
		LRR_RI	<58..236	CDD:238064	55/186 (30%)
		LRR_8	78..141	CDD:290566	19/68 (28%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		leucine-rich repeat	103..130	CDD:275380	7/32 (22%)
		leucine-rich repeat	131..155	CDD:275380	8/23 (35%)
		LRR_8	156..214	CDD:290566	19/58 (33%)
		leucine-rich repeat	158..182	CDD:275380	3/23 (13%)
		LRR_8	202..285	CDD:290566	27/90 (30%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		leucine-rich repeat	254..274	CDD:275380	6/22 (27%)
		LRR_8	273..333	CDD:290566	20/59 (34%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR_RI	277..>471	CDD:238064	49/202 (24%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR_8	321..402	CDD:290566	22/80 (28%)
		leucine-rich repeat	323..346	CDD:275380	7/22 (32%)
		leucine-rich repeat	347..391	CDD:275380	9/43 (21%)
		leucine-rich repeat	392..413	CDD:275380	7/20 (35%)
		LRR_8	393..448	CDD:290566	13/54 (24%)
		leucine-rich repeat	414..437	CDD:275380	3/22 (14%)
		LRRCT	471..517	CDD:214507	5/19 (26%)
lron-15	NP_495322.3	LRR_8	95..155	CDD:290566
		leucine-rich repeat	120..144	CDD:275380
		LRR_RI	<144..348	CDD:238064
		LRR_8	144..205	CDD:290566
		leucine-rich repeat	145..168	CDD:275380
		leucine-rich repeat	169..194	CDD:275380
		leucine-rich repeat	195..217	CDD:275380
		LRR_8	217..274	CDD:290566
		leucine-rich repeat	218..239	CDD:275380
		leucine-rich repeat	240..263	CDD:275380
		leucine-rich repeat	264..311	CDD:275380
		LRR_8	289..346	CDD:290566
		leucine-rich repeat	312..335	CDD:275380
		leucine-rich repeat	336..356	CDD:275380
		LRR_RI	<338..498	CDD:238064	31/115 (27%)
		leucine-rich repeat	361..383	CDD:275380
		leucine-rich repeat	384..405	CDD:275380	7/18 (39%)
		LRR_8	408..473	CDD:290566	19/68 (28%)
		leucine-rich repeat	409..432	CDD:275380	7/22 (32%)
		leucine-rich repeat	433..462	CDD:275380	7/32 (22%)
		LRR_8	461..522	CDD:290566	18/63 (29%)
		leucine-rich repeat	463..487	CDD:275380	8/23 (35%)
		leucine-rich repeat	488..511	CDD:275380	3/25 (12%)
		LRR_8	510..568	CDD:290566	23/57 (40%)
		LRR_4	510..551	CDD:289563	17/40 (43%)
		leucine-rich repeat	512..533	CDD:275380	10/20 (50%)
		LRR_4	533..573	CDD:289563	12/39 (31%)
		leucine-rich repeat	534..557	CDD:275380	8/22 (36%)
		leucine-rich repeat	558..581	CDD:275380	8/22 (36%)
		LRR_8	583..642	CDD:290566	19/63 (30%)
		leucine-rich repeat	584..607	CDD:275380	6/22 (27%)
		LRR_RI	<607..799	CDD:238064	50/212 (24%)
		leucine-rich repeat	608..631	CDD:275380	8/22 (36%)
		LRR_8	630..688	CDD:290566	19/57 (33%)
		leucine-rich repeat	632..655	CDD:275380	8/22 (36%)
		leucine-rich repeat	656..676	CDD:275380	6/19 (32%)
		leucine-rich repeat	680..703	CDD:275380	9/43 (21%)
		leucine-rich repeat	704..749	CDD:275380	10/44 (23%)
		leucine-rich repeat	726..739	CDD:275378	3/12 (25%)
		LRR_8	748..808	CDD:290566	10/60 (17%)
		leucine-rich repeat	750..771	CDD:275380	2/20 (10%)
		leucine-rich repeat	774..797	CDD:275380	3/22 (14%)
		LRR_8	797..856	CDD:290566	5/14 (36%)
		LRR_RI	<798..982	CDD:238064	5/13 (38%)
		leucine-rich repeat	798..845	CDD:275380	5/13 (38%)
		LRR_8	845..904	CDD:290566
		leucine-rich repeat	846..869	CDD:275380
		leucine-rich repeat	870..893	CDD:275380
		leucine-rich repeat	894..915	CDD:275380
		LRR_8	938..998	CDD:290566
		leucine-rich repeat	940..963	CDD:275380
		leucine-rich repeat	964..987	CDD:275380
		leucine-rich repeat	988..1009	CDD:275380
		leucine-rich repeat	1038..1064	CDD:275380
		leucine-rich repeat	1113..1139	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910