DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and egg-6

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	131/571 - (22%)
Similarity:	236/571 - (41%)	Gaps:	145/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRIVLELALLVLGVISSCRAVNC---PWPCRCTWVVDSLYADCSRRSLQTYPN------------ 50
            ||.:..:|:..|....|...:.|   |..|.|......:...|:...::|...
Worm     1 MRWLTLIAVAHLIAFLSSAEITCPRIPEKCDCKISKSMIILSCNGEDVKTIAQTVGTSQIDELHI 65

  Fly    51 ------------FDGI-----------------------PVEHLDLSGNKFLEFPTLYADIDSLI 80
                        |:|:                       .:||:.::||:....| ::.::.:|:
Worm    66 LNGTDVKIESLPFNGLRTIAILNSTLQSFSPTAWRHVEATIEHITINGNELKTVP-VFGNLSTLM 129

  Fly    81 YLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSW--ESLSPNEAFKYAPSLKRLGLDGNRLGS 143
            .::|:||.||||..|...|.::|..|.|.||:|..:  :||...:|     ||..|.:.||.|.:
Worm   130 SMNLNSNQISSIPDKAFNGLSALTQLRLENNAICDFPPKSLDAVKA-----SLVLLDVSGNCLDA 189

  Fly   144 FGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQI---AALPSRTLR 205
            .   .:..|..:::|..|.|.|..||.|...:::| ||.|..|.:.||.|.:|   |.:....|:
Worm   190 I---PAQILRNAANLMYLDLGSNNISEINNFELMN-LPFLRELRVQNNTLRRIHPMAFMNVPQLQ 250

  Fly   206 VLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYMLRKLDVSYCNLDSIELS 270
            .|.|.:..|..|.|..|...:|||.|::|.|......||.:
Worm   251 YLYLQDNIISTLDGNRLQGFKNLEVLDVSNNALYALPSLKD------------------------ 291

  Fly   271 GLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEIAR 335
             ||.|.:||:.|||:..::...|:||..|:::.:..|.:..|.:::|..|.:|..|.:..|.:|:
Worm   292 -LPNLKQVRVDGNLITKIETLAFSNNPNLQLISVQNNNIVQISRNSFESLDKLVVLLVGNNSLAK 355

  Fly   336 LDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCEITSIESTALSSLSVIQKLDLSNN 400
            ::|........|.:|::..|.|                     |::::::.:.|:.:..|||.:|
Worm   356 IERGMFDGMKNLQQLSIRNNTL---------------------TALDASSFAQLAHLTTLDLGHN 399

  Fly   401 LITDMP--TFMRSETLQQLNLANCRLTTVRNNTFREFPELADLHLNGNRLTSPIPPNYFDGNKFL 463
            .|.|:.  ||.:...|..|:|:|.:::..:.:.|::  :::::.|:||:|
Worm   400 KIHDIEEGTFDKLSKLFWLDLSNNKISGFKTSVFKK--KISNILLDGNQL--------------- 447

  Fly   464 DQLWLGDNPWICDCHSPLFVDFYDYLTAKPAK--IKDRNHLRCAAPAVFYG 512
                      |||   ..|.:|..||.|...:  :..:..:.|..|..:.|
Worm   448 ----------ICD---ESFNEFLTYLIANKVRTFLPFQQEIMCHGPEKYAG 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	5/21 (24%)
		LRR_RI	<58..236	CDD:238064	59/182 (32%)
		LRR_8	78..141	CDD:290566	24/64 (38%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		leucine-rich repeat	103..130	CDD:275380	9/28 (32%)
		leucine-rich repeat	131..155	CDD:275380	6/23 (26%)
		LRR_8	156..214	CDD:290566	20/60 (33%)
		leucine-rich repeat	158..182	CDD:275380	9/23 (39%)
		LRR_8	202..285	CDD:290566	22/82 (27%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	254..274	CDD:275380	1/19 (5%)
		LRR_8	273..333	CDD:290566	18/59 (31%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
		LRR_RI	277..>471	CDD:238064	41/195 (21%)
		leucine-rich repeat	299..322	CDD:275380	5/22 (23%)
		LRR_8	321..402	CDD:290566	15/80 (19%)
		leucine-rich repeat	323..346	CDD:275380	5/22 (23%)
		leucine-rich repeat	347..391	CDD:275380	6/43 (14%)
		leucine-rich repeat	392..413	CDD:275380	8/22 (36%)
		LRR_8	393..448	CDD:290566	16/56 (29%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
		LRRCT	471..517	CDD:214507	11/44 (25%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	20/55 (36%)
		leucine-rich repeat	107..127	CDD:275380	5/20 (25%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		LRR_RI	<144..281	CDD:238064	47/145 (32%)
		leucine-rich repeat	152..200	CDD:275380	16/55 (29%)
		LRR_8	176..233	CDD:290566	19/60 (32%)
		leucine-rich repeat	201..224	CDD:275380	9/23 (39%)
		LRR_8	225..283	CDD:290566	20/57 (35%)
		leucine-rich repeat	225..248	CDD:275380	7/22 (32%)
		LRR_RI	<240..458	CDD:238064	65/293 (22%)
		leucine-rich repeat	249..272	CDD:275380	7/22 (32%)
		LRR_8	271..329	CDD:290566	21/82 (26%)
		leucine-rich repeat	273..294	CDD:275380	8/45 (18%)
		leucine-rich repeat	295..318	CDD:275380	9/22 (41%)
		LRR_8	317..375	CDD:290566	12/57 (21%)
		leucine-rich repeat	319..342	CDD:275380	5/22 (23%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		LRR_8	365..425	CDD:290566	18/80 (23%)
		leucine-rich repeat	367..390	CDD:275380	6/43 (14%)
		leucine-rich repeat	391..414	CDD:275380	8/22 (36%)
		leucine-rich repeat	415..434	CDD:275380	4/18 (22%)
		leucine-rich repeat	437..449	CDD:275378	4/36 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910