DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and Igfals

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus

Alignment Length:	600	Identity:	159/600 - (26%)
Similarity:	238/600 - (39%)	Gaps:	149/600 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GVISSCRAVNCPWPCRCTW--VVDSLYADCSRRSLQTYPNFDGIPV--EHLDLSGNKFLEFPT-L 72
            |..:......||..|.|::  ..|.|...||.|:|...|  |.|||  ..|.|.||.....|: .
Mouse    66 GASADAEGPQCPVTCTCSYDDYTDELSVFCSSRNLTQLP--DSIPVSTRALWLDGNNLSSIPSAA 128

  Fly    73 YADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFKYAPSLKRLGLD 137
            :.::.||.:|:|..:::.|:..:.|:|..:|..|.|..|.:   .||:.. .|::.|||..|.|.
Mouse   129 FQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLL---RSLAAG-LFRHTPSLASLSLG 189

  Fly   138 GNRLGSFGNGESFELLTSSSLTDLGLSSCGISS--IGGDQMVNQLPNLERLNLANNQL-----AQ 195
            .|.||....| .|..|  |.|.||.|   |.:|  :..|.:...|.||..|.||.|:|     |.
Mouse   190 NNLLGRLEEG-LFRGL--SHLWDLNL---GWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPAL 248

  Fly   196 IAALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYM------- 253
            :..|..  ||.||||..:::::.......:..|:.|.|.||            ::|.:
Mouse   249 LCGLGE--LRELDLSRNALRSVKANVFIHLPRLQKLYLDRN------------LITAVAPRAFLG 299

  Fly   254 ---LRKLDVSYCNLDSI---ELSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHI 312
               ||.||:|:..:..:   ...||..|..:||..|.:..:...||.:...||.:.|..|.:|.:
Mouse   300 MKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQL 364

  Fly   313 GQDAFAKLKRLKELNLAFNEIARLDRN-FIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWC 376
            |:..|..|.:|:.|.|..|:|..:... |....:|.| :|||.|.|:.|.:.|...:..::....
Mouse   365 GEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAV-MNLSGNCLRSLPEHVFQGLGRLHSLHL 428

  Fly   377 E---------------------------ITSIESTALSSLSVIQKLDLSNNLITDMP-------- 406
            |                           |:|||..:|:.||.:.:|||:.|.:|.:|
Mouse   429 EHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLG 493

  Fly   407 ------------TFMRSETLQQ------LNLANCRLTTVRNNTFREFPELADLHLNGNRLTSPIP 453
                        |.:..:.|..      |:|::.||.|.....|.....|..|:|..|.|.:.:|
Mouse   494 QLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVP 558

  Fly   454 -PNYFDGNKFLDQLWLGDNPWICDCHSPLFVDF------------------------YDYLTAKP 493
             |.       |::|||..|||.|.|......||                        |.|
Mouse   559 QPG-------LERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCEGDDCQPVYTY----- 611

  Fly   494 AKIKDRNHLRCAAPA 508
                  |::.||.||
Mouse   612 ------NNITCAGPA 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	6/24 (25%)
		LRR_RI	<58..236	CDD:238064	57/185 (31%)
		LRR_8	78..141	CDD:290566	20/62 (32%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..130	CDD:275380	7/26 (27%)
		leucine-rich repeat	131..155	CDD:275380	9/23 (39%)
		LRR_8	156..214	CDD:290566	24/64 (38%)
		leucine-rich repeat	158..182	CDD:275380	8/25 (32%)
		LRR_8	202..285	CDD:290566	23/95 (24%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	254..274	CDD:275380	7/22 (32%)
		LRR_8	273..333	CDD:290566	18/59 (31%)
		leucine-rich repeat	275..298	CDD:275380	6/22 (27%)
		LRR_RI	277..>471	CDD:238064	61/248 (25%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR_8	321..402	CDD:290566	27/108 (25%)
		leucine-rich repeat	323..346	CDD:275380	6/23 (26%)
		leucine-rich repeat	347..391	CDD:275380	15/70 (21%)
		leucine-rich repeat	392..413	CDD:275380	7/40 (18%)
		LRR_8	393..448	CDD:290566	18/80 (23%)
		leucine-rich repeat	414..437	CDD:275380	7/28 (25%)
		LRRCT	471..517	CDD:214507	13/61 (21%)
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470	15/39 (38%)
		leucine-rich repeat	92..110	CDD:275380	8/19 (42%)
		PLN00113	96..>558	CDD:331614	131/488 (27%)
		leucine-rich repeat	114..134	CDD:275380	5/19 (26%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	7/26 (27%)
		leucine-rich repeat	183..206	CDD:275380	9/25 (36%)
		leucine-rich repeat	207..230	CDD:275380	8/25 (32%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	6/34 (18%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..396	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..446	CDD:275380	1/22 (5%)
		leucine-rich repeat	447..470	CDD:275380	6/22 (27%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		leucine-rich repeat	495..516	CDD:275380	2/20 (10%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..561	CDD:275380	6/17 (35%)
		TPKR_C2	570..613	CDD:326558	9/53 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910