DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dve and SATB2

DIOPT Version :9

Sequence 1:	NP_477242.1	Gene:	dve / 37546	FlyBaseID:	FBgn0020307	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_001165980.1	Gene:	SATB2 / 23314	HGNCID:	21637	Length:	733	Species:	Homo sapiens

Alignment Length:	909	Identity:	185/909 - (20%)
Similarity:	288/909 - (31%)	Gaps:	341/909 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 RRSSEGTPPTAHPPTNSEGQALSSSTASSSQNATPKSDRERERERERDREERVERGSISCLPPAA 214
            |||  |:|....||        ....|...||.:|...|.|                    |..|
Human    16 RRS--GSPDVKGPP--------PVKVARLEQNGSPMGARGR--------------------PNGA 50

  Fly   215 LGMAVGVQQAQHQEKLLSHPALDSRREFDVSKVNPKSLPLHCVVESVHSLHASLTIDTRQPWKRR 279
            :..|||                            ...:|:.||||   .|..||..|.|:
Human    51 VAKAVG----------------------------GLMIPVFCVVE---QLDGSLEYDNRE----- 79

  Fly   280 PNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPLEQISDNPAVPVSD 344
               |...:|::.....:|::|:|||..||||...|..|:|.:.:..|.|:||..::|.|...|:|
Human    80 ---EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVAD 141

  Fly   345 IVGELTSVITLRIVI--------LRPKTSPFGEIKDKLLKLLVLQSHAVLRSTGCPLDEVTLSQI 401
            ::.::..|:||:|.:        |..:......:::.|.:||...:.:.| :..|||.:..:|.|
Human   142 MLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALKELLKEMNQSTL-AKECPLSQSMISSI 205

  Fly   402 CRSSHQNTYALPGGEISDELRRKFDQWWS------------NQLSPQAT-AMTPKMLPFMTGPSA 453
            ..|::   ||    .:|....::|.:|:.            ..||.... ...|..||.|
Human   206 VNSTY---YA----NVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNM----- 258

  Fly   454 VPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLANEAAHHAGAGQA 518
                                                  |.|.|:|.      .||        |:
Human   259 --------------------------------------NQLASLGK------TNE--------QS 271

  Fly   519 PGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPNQKTRMRTSFDPEMELPKLQKWFADNPHPS 583
            |             |:.:|          |..|..||...::....|.:..|:|      :|...
Human   272 P-------------HSQIH----------HSTPIRNQVPALQPIMSPGLLSPQL------SPQLV 307

  Fly   584 RQQI-QTYVVQLNALESR---------------------RGRKP------LDVNNVVYWFKNARA 620
            |||| ..:::......||                     |..||      ::|:..:|
Human   308 RQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEVSPDIY------- 365

  Fly   621 AQKRAEMRGGSLGSAISALGHAAMN---GYLSQHAPLGQNSSSSAGSQPMSMGNLSMSHDYLKSP 682
            .|.|.|::..|:..|:.|  ..|.|   |.||:  .|.:.......||.: :.||....::|..|
Human   366 QQVRDELKRASVSQAVFA--RVAFNRTQGLLSE--ILRKEEDPRTASQSL-LVNLRAMQNFLNLP 425

  Fly   683 LSLKSEDIDTMSQHSDDMDEEQSRPNTPQL------PLSLTTHERHRSSPLMDEDEDEAGEQQQP 741
                ..:.|.:.|   |..|....||...:      |.|..|.:...|:|..|
Human   426 ----EVERDRIYQ---DERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTD------------ 471

  Fly   742 QEAKSDGMN----GSVKDEERQEKSRDELQD--------NE-----------KENSNGEDRHL-- 781
            ...|.||.|    .::.||.:||..|.::..        |:           |||.:.|:|.|
Human   472 LPIKVDGANINITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWE 536

  Fly   782 --------------DADAQMEASSNLNNNHNNSSLHIEQ-----------EVGSTPKRSTPKEED 821
                          :.|...|..|  .::|:....|:.|           :.....|.|:|..|:
Human   537 NLCTIRRFLNLPQHERDVIYEEES--RHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREE 599

  Fly   822 --------DDLDMDEDEEDNENDASHLDEFRSPSPDLAGGVVPHKD-------QLPFPMVPNSMF 871
                    :|....:.....:.....|...:|...|:  |:.|.::       ||..|
Human   600 APPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDV--GLYPDQEAIHTLSAQLDLP------- 655

  Fly   872 SQSFMYMSHYIPAFGQAAAGHPHHHA------AAAAAAAGIQPNALMGGGGLNLSSISNEERRK 929
                   .|.|..|.|....|..||.      .:|...|..:...|:.....|.|...:||..|
Human   656 -------KHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dve	NP_477242.1	SATB1_N	252..358	CDD:211426	35/105 (33%)
		HOX	556..623	CDD:197696	15/94 (16%)
		PPP4R2	<644..778	CDD:286293	36/165 (22%)
		HOX	928..995	CDD:197696	1/2 (50%)
SATB2	NP_001165980.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		13/60 (22%)
		SATB1_N	60..155	CDD:211426	35/105 (33%)
		CUTL	162..232	CDD:406861	16/77 (21%)
		CUT	355..433	CDD:396794	21/93 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..473		10/49 (20%)
		CUT	477..556	CDD:396794	16/78 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..617		5/36 (14%)
		HOX	614..671	CDD:197696	13/72 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..733		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159378
Domainoid	1	1.000	64	1.000	Domainoid score	I10126
eggNOG	1	0.900	-	-		E1_KOG3755
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40416
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4065
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860