DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dve and Satb2

DIOPT Version :9

Sequence 1:	NP_477242.1	Gene:	dve / 37546	FlyBaseID:	FBgn0020307	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	XP_006495890.1	Gene:	Satb2 / 212712	MGIID:	2679336	Length:	740	Species:	Mus musculus

Alignment Length:	909	Identity:	186/909 - (20%)
Similarity:	291/909 - (32%)	Gaps:	334/909 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 RRSSEGTPPTAHPPTNSEGQALSSSTASSSQNATPKSDRERERERERDREERVERGSISCLPPAA 214
            |||  |:|....||        ....|...||.:|...|.|                    |..|
Mouse    16 RRS--GSPDVKGPP--------PVKVARLEQNGSPMGARGR--------------------PNGA 50

  Fly   215 LGMAVGVQQAQHQEKLLSHPALDSRREFDVSKVNPKSLPLHCVVESVHSLHASLTIDTRQPWKRR 279
            :..|||....:                     :....:|:.||||   .|..||..|.|:
Mouse    51 VAKAVGGNSPE---------------------LGGLMIPVFCVVE---QLDGSLEYDNRE----- 86

  Fly   280 PNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPLEQISDNPAVPVSD 344
               |...:|::.....:|::|:|||..||||...|..|:|.:.:..|.|:||..::|.|...|:|
Mouse    87 ---EHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVAD 148

  Fly   345 IVGELTSVITLRIVI--------LRPKTSPFGEIKDKLLKLLVLQSHAVLRSTGCPLDEVTLSQI 401
            ::.::..|:||:|.:        |..:......:::.|.:||...:.:.| :..|||.:..:|.|
Mouse   149 MLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALKELLKEMNQSTL-AKECPLSQSMISSI 212

  Fly   402 CRSSHQNTYALPGGEISDELRRKFDQWWS------------NQLSPQAT-AMTPKMLPFMTGPSA 453
            ..|::   ||    .:|....::|.:|:.            ..||.... ...|..||.|
Mouse   213 VNSTY---YA----NVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNM----- 265

  Fly   454 VPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLANEAAHHAGAGQA 518
                                                  |.|.|:|.      .||        |:
Mouse   266 --------------------------------------NQLASLGK------TNE--------QS 278

  Fly   519 PGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPNQKTRMRTSFDPEMELPKLQKWFADNPHPS 583
            |             |:.:|          |..|..||...::....|.:..|:|      :|...
Mouse   279 P-------------HSQIH----------HSTPIRNQVPALQPIMSPGLLSPQL------SPQLV 314

  Fly   584 RQQI-QTYVVQLNALESR---------------------RGRKP------LDVNNVVYWFKNARA 620
            |||| ..:::......||                     |..||      ::|:..:|
Mouse   315 RQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEVSPDIY------- 372

  Fly   621 AQKRAEMRGGSLGSAISALGHAAMN---GYLSQHAPLGQNSSSSAGSQPMSMGNLSMSHDYLKSP 682
            .|.|.|::..|:..|:.|  ..|.|   |.||:  .|.:.......||.: :.||....::|..|
Mouse   373 QQVRDELKRASVSQAVFA--RVAFNRTQGLLSE--ILRKEEDPRTASQSL-LVNLRAMQNFLNLP 432

  Fly   683 LSLKSEDIDTMSQHSDDMDEEQSRPNTPQL------PLSLTTHERHRSSPLMDEDEDEAGEQQQP 741
                ..:.|.:.|   |..|....||...:      |.|..|.:...|:|..|
Mouse   433 ----EVERDRIYQ---DERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTD------------ 478

  Fly   742 QEAKSDGMN----GSVKDEERQEKSRDELQD--------NE-----------KENSNGEDRHL-- 781
            ...|.||.|    .::.||.:||..|.::..        |:           |||.:.|:|.|
Mouse   479 LPIKVDGANVNITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWE 543

  Fly   782 --------------DADAQMEASSNLNNNHNNSSLHI------------EQEVGSTPKRSTPKEE 820
                          :.|...|..|  .::|:....|:            .|:...|.:.|.|:||
Mouse   544 NLCTIRRFLNLPQHERDVIYEEES--RHHHSERMQHVVQLPPEPVQVLHRQQSQPTKESSPPREE 606

  Fly   821 -------DDDLDMDEDEEDNENDASHLDEFRSPSPDLAGGVVPHKD-------QLPFPMVPNSMF 871
                   .:|....:.....:.....|...:|...|:  |:.|.::       ||..|
Mouse   607 APPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDV--GLYPDQEAIHTLSAQLDLP------- 662

  Fly   872 SQSFMYMSHYIPAFGQAAAGHPHHHA------AAAAAAAGIQPNALMGGGGLNLSSISNEERRK 929
                   .|.|..|.|....|..||.      .:|...|..:...|:.....|.|...:||..|
Mouse   663 -------KHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dve	NP_477242.1	SATB1_N	252..358	CDD:211426	35/105 (33%)
		HOX	556..623	CDD:197696	15/94 (16%)
		PPP4R2	<644..778	CDD:286293	36/165 (22%)
		HOX	928..995	CDD:197696	1/2 (50%)
Satb2	XP_006495890.1	SATB1_N	67..162	CDD:211426	35/105 (33%)
		CUTL	169..239	CDD:406861	16/77 (21%)
		CUT	362..440	CDD:396794	21/93 (23%)
		CUT	484..563	CDD:396794	16/78 (21%)
		HOX	621..678	CDD:197696	13/72 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849748
Domainoid	1	1.000	64	1.000	Domainoid score	I10091
eggNOG	1	0.900	-	-		E1_KOG3755
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42490
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4065
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860