Protein Alignment dve and dve-1

DIOPT Version :10

• Sequence 1: NP_477242.1
• Gene: dve / 37546
• FlyBaseID: FBgn0020307
• Length: 1024
• Species: Drosophila melanogaster
• Sequence 2: NP_001024984.1
• Gene: dve-1 / 180398
• WormBaseID: WBGene00022861
• Length: 468
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 158/752 - (21%)
• Similarity: 251/752 - (33%)
• Gaps: 307/752 - (40%)

  Fly   253 PLHCVVESVHSLHASLTIDTRQPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTA 317
            |:..:||:|.|.|. ||.      ....::.||:|.|:|..|..:::|:|.|..||:| .::.:|
 Worm     3 PMRVIVETVRSQHC-LTC------SNEGHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSA 59

  Fly   318 RGSLIIKHWKPIPLEQISDNPAVPVSDIVGELTSVITLRIVILRPKTSP-----FGEIKDKLLKL 377
            ||.:.:.:|||:|.:||::|....|.::..:::|.:.|:| :.:|.|..     ..|:|:||||.
 Worm    60 RGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKI-LSKPSTDSNSVQCISEVKNKLLKA 123

  Fly   378 LVLQSHAVLRSTGCPLDEVTLSQICRSSHQNTYALPGGEISDELRRKFDQWWSNQLSPQATAMTP 442
            .|.::..||.:    :|...:..:.     ||..     ..||.....:|
 Worm   124 AVNKNPNVLTN----VDNQQVKDVI-----NTII-----AGDETLLNSEQ--------------- 159

  Fly   443 KMLPFMTGPSAVPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLAN 507
                                                               :|::......|..|
 Worm   160 ---------------------------------------------------IGAVNEWLDTLETN 173

  Fly   508 EAAHHAGAGQAPGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPNQKTRMRTSFDPEMELPKL 572
            |....                                        |.|..|..|.:    |:|:|
 Worm   174 EDRRS----------------------------------------PTQVQRFNTLY----EIPRL 194

  Fly   573 QKWFADNPHPSRQQIQTYVVQLNALESRRGRKPLDVNNVVYWFKNARAAQKRAEMRGGSLGSAIS 637
            .|||..:.:||:|::..|:.|||....|:....:....:..||     .|||:..|
 Worm   195 DKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWF-----TQKRSSSR--------- 245

  Fly   638 ALGHAAMNGYLSQHAP--LGQNSSSSAGSQPMSMGNLSMSHDYLKSPLSLKSEDIDTMSQHSDDM 700
                        ..||  |.|.||:...:|.:
 Worm   246 ------------TLAPVDLVQVSSAQTAAQLL--------------------------------- 265

  Fly   701 DEEQSRPNTPQLPLSLTTHERHRSSPLMDEDEDEAGEQQQPQEAKSDGMNGSVKDEERQEKSRDE 765
                     |...|:|.              :...|||:|    |.|              ..|:
 Worm   266 ---------PGFQLNLL--------------QSLFGEQRQ----KFD--------------FYDK 289

  Fly   766 LQDNEKENSNGEDRHLDADAQMEASSNLNNNHNNSSLHIEQEVGSTPKRSTPKEEDDDLDMDEDE 830
            |  :|.:...|.|....||.::         |:||...|:..:.|...:..|     ::|.....
 Worm   290 L--DETKIVGGSDSPSPADDEI---------HSNSDETIQDTLFSINIKPEP-----EIDSIASS 338

  Fly   831 EDNENDASHLDEFRSPSPDLAGGVVPHKDQLPFPMVPNSMFSQSFMYMSHYIPAFGQAAAGHPHH 895
            .|..|  |..:...|.||.|..|:                          .:.||..
 Worm   339 PDMAN--SMRESLSSTSPKLLSGL--------------------------DLGAFST-------- 367

  Fly   896 HAAAAAAAAGIQPNALMGGGGLNLSSISNEERRKRNRTFIDPVTEVPKLEQWFAMNTHPSHNLIL 960
            |:::.        |::........|:       .|:|...||:||:|.||:||..|.||:...|.
 Worm   368 HSSST--------NSMQNANSSVFSA-------ARSRLMFDPLTELPVLEKWFEENPHPTWMQID 417

  Fly   961 KYTEDLNTMPYRQKFPRLESKNVQFWFKNRRAKCKRL 997
            :||:.||...||:.:|.:...||:.||||||||||||
 Worm   418 QYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRL 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dve	NP_477242.1	ULD	250..359	CDD:465165	34/105 (32%)
		HOX	556..623	CDD:197696	18/66 (27%)
		HOX	928..995	CDD:197696	32/66 (48%)
dve-1	NP_001024984.1	SATB1_N	2..100	CDD:211426	34/105 (32%)
		HOX	187..245	CDD:197696	20/66 (30%)
		HOX	387..452	CDD:197696	32/64 (50%)