DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dve and dve-1

DIOPT Version :9

Sequence 1:	NP_477242.1	Gene:	dve / 37546	FlyBaseID:	FBgn0020307	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_001024984.1	Gene:	dve-1 / 180398	WormBaseID:	WBGene00022861	Length:	468	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	158/752 - (21%)
Similarity:	251/752 - (33%)	Gaps:	307/752 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 PLHCVVESVHSLHASLTIDTRQPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTA 317
            |:..:||:|.|.|. ||.      ....::.||:|.|:|..|..:::|:|.|..||:| .::.:|
Worm     3 PMRVIVETVRSQHC-LTC------SNEGHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSA 59

  Fly   318 RGSLIIKHWKPIPLEQISDNPAVPVSDIVGELTSVITLRIVILRPKTSP-----FGEIKDKLLKL 377
            ||.:.:.:|||:|.:||::|....|.::..:::|.:.|:| :.:|.|..     ..|:|:||||.
Worm    60 RGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKI-LSKPSTDSNSVQCISEVKNKLLKA 123

  Fly   378 LVLQSHAVLRSTGCPLDEVTLSQICRSSHQNTYALPGGEISDELRRKFDQWWSNQLSPQATAMTP 442
            .|.::..||.:    :|...:..:.     ||..     ..||.....:|
Worm   124 AVNKNPNVLTN----VDNQQVKDVI-----NTII-----AGDETLLNSEQ--------------- 159

  Fly   443 KMLPFMTGPSAVPVPVAVPGEMDFPVGTAMAAAAAAAAHAAAAGGAAGGNPLGSMGSRESLLLAN 507
                                                               :|::......|..|
Worm   160 ---------------------------------------------------IGAVNEWLDTLETN 173

  Fly   508 EAAHHAGAGQAPGPGHHGSMLVHPMHASMHHHHHHGGGGGHGPPYPNQKTRMRTSFDPEMELPKL 572
            |....                                        |.|..|..|.:    |:|:|
Worm   174 EDRRS----------------------------------------PTQVQRFNTLY----EIPRL 194

  Fly   573 QKWFADNPHPSRQQIQTYVVQLNALESRRGRKPLDVNNVVYWFKNARAAQKRAEMRGGSLGSAIS 637
            .|||..:.:||:|::..|:.|||....|:....:....:..||     .|||:..|
Worm   195 DKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWF-----TQKRSSSR--------- 245

  Fly   638 ALGHAAMNGYLSQHAP--LGQNSSSSAGSQPMSMGNLSMSHDYLKSPLSLKSEDIDTMSQHSDDM 700
                        ..||  |.|.||:...:|.:
Worm   246 ------------TLAPVDLVQVSSAQTAAQLL--------------------------------- 265

  Fly   701 DEEQSRPNTPQLPLSLTTHERHRSSPLMDEDEDEAGEQQQPQEAKSDGMNGSVKDEERQEKSRDE 765
                     |...|:|.              :...|||:|    |.|              ..|:
Worm   266 ---------PGFQLNLL--------------QSLFGEQRQ----KFD--------------FYDK 289

  Fly   766 LQDNEKENSNGEDRHLDADAQMEASSNLNNNHNNSSLHIEQEVGSTPKRSTPKEEDDDLDMDEDE 830
            |  :|.:...|.|....||.::         |:||...|:..:.|...:..|     ::|.....
Worm   290 L--DETKIVGGSDSPSPADDEI---------HSNSDETIQDTLFSINIKPEP-----EIDSIASS 338

  Fly   831 EDNENDASHLDEFRSPSPDLAGGVVPHKDQLPFPMVPNSMFSQSFMYMSHYIPAFGQAAAGHPHH 895
            .|..|  |..:...|.||.|..|:                          .:.||..
Worm   339 PDMAN--SMRESLSSTSPKLLSGL--------------------------DLGAFST-------- 367

  Fly   896 HAAAAAAAAGIQPNALMGGGGLNLSSISNEERRKRNRTFIDPVTEVPKLEQWFAMNTHPSHNLIL 960
            |:::.        |::........|:       .|:|...||:||:|.||:||..|.||:...|.
Worm   368 HSSST--------NSMQNANSSVFSA-------ARSRLMFDPLTELPVLEKWFEENPHPTWMQID 417

  Fly   961 KYTEDLNTMPYRQKFPRLESKNVQFWFKNRRAKCKRL 997
            :||:.||...||:.:|.:...||:.||||||||||||
Worm   418 QYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dve	NP_477242.1	SATB1_N	252..358	CDD:211426	33/104 (32%)
		HOX	556..623	CDD:197696	18/66 (27%)
		PPP4R2	<644..778	CDD:286293	20/135 (15%)
		HOX	928..995	CDD:197696	32/66 (48%)
dve-1	NP_001024984.1	SATB1_N	2..100	CDD:211426	34/105 (32%)
		HOX	187..245	CDD:197696	20/66 (30%)
		HOX	387..452	CDD:197696	32/64 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166997
Domainoid	1	1.000	73	1.000	Domainoid score	I6027
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I2455
Isobase	1	0.950	-	0	Normalized mean entropy	S7927
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0014302
OrthoInspector	1	1.000	-	-		oto20021
orthoMCL	1	0.900	-	-		OOG6_116651
Panther	1	1.100	-	-	LDO	PTHR15116
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.930