DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dve and satb1

DIOPT Version :9

Sequence 1:	NP_477242.1	Gene:	dve / 37546	FlyBaseID:	FBgn0020307	Length:	1024	Species:	Drosophila melanogaster
Sequence 2:	NP_001093671.1	Gene:	satb1 / 100101659	XenbaseID:	XB-GENE-854103	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	898	Identity:	167/898 - (18%)
Similarity:	312/898 - (34%)	Gaps:	258/898 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 TNSEGQALSSSTASSSQNATPKSDRERERERERDREERVERGSISCLPPAALGMAVGVQQAQHQE 228
            :|...|.:..|..|::.| .||....:....|::......||.:........|:.:     :|..
Frog     4 SNETTQGIEHSEMSNNVN-DPKGPPAKIARLEQNGSPLGGRGRLGSTGSKMHGVPL-----RHSS 62

  Fly   229 KLLSHPALDSRREFDVSKVNPKSLPLHCVVESVHSLHASLTIDTRQPWKRRPNIETDSYVIIAAA 293
            :|:         ..::.|.|  .:|:.||||...:.   :..|.::        |...:|::...
Frog    63 QLI---------RTNIRKGN--MIPVFCVVEHYENF---IEYDCKE--------EHAEFVLVRKD 105

  Fly   294 TPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPLEQISDNPAVPVSDIVGELTSVITLRIV 358
            ..::::::.||..||||...|..|:|.:.:..|.|:||..::|.|...|:|::.::..|:||:|.
Frog   106 MLFNQLIEMALLSLGYSHSAAAQAKGLIQVGKWNPVPLSCVTDAPDATVADMLQDVFHVVTLKIQ 170

  Fly   359 I--------LRPKTSPFGEIKDKLLKLLVLQSHAVLRSTGCPLDEVTLSQICRSSHQNTYALPGG 415
            :        |.|:......:::.|..||...:.:.| :..|||.:..:|.|..|::   ||
Frog   171 LHSCPKLEDLPPEQWSHITVRNALKDLLKDMNQSSL-AKECPLSQSMISSIVNSTY---YA---- 227

  Fly   416 EISDELRRKFDQWWSNQLSPQATAMTPKMLPFMTGPSAVPVPVAVPGEMDFPVGTAMAAAAAAAA 480
            .:|....::|.:|:.:....:                          ||...:......:..::.
Frog   228 NVSAAKCQEFGRWYKHFKKTK--------------------------EMMVDIEELSERSQQSSN 266

  Fly   481 HAAAAGGAAGGNPLGSMGSRESLLLANEAAHHA-GAGQAPGPGHHGSMLVHPMHASMHHHHHHGG 544
            |...      |...||:|:.|:.....:.:|.: ...:.|.|..|..::..|:
Frog   267 HVNY------GQQPGSVGTPENPSSPVQISHSSQPPARTPLPNLHPGLVSTPI------------ 313

  Fly   545 GGGHGPPYPNQKTRMRTSFDPEMELPK------LQKWFADNPHPSRQQIQTYVVQLNALESRRGR 603
                .|...||:..|....:.:..:.:      |.:.:.::|.|               .||...
Frog   314 ----SPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPP---------------VSRSIN 359

  Fly   604 KPL--------DVNNVVY-WFKNARAAQKRAEMRGGSLGSAISALGHAAMN---GYLSQHAPLGQ 656
            |||        :|::.:| |.        |.|::...:..|:.|  ..|.|   |.||:  .|.:
Frog   360 KPLEQQVSPNTEVSSDIYQWV--------RDELKRAGISQAVFA--RVAFNRTQGLLSE--ILRK 412

  Fly   657 NSSSSAGSQPMSMGNLSMSHDYLKSPLSLKSEDIDTMSQHSDDMDEEQSRPNT--PQLPLSLTTH 719
            .......||.: :.||....::|:.|    ..:.|.:.|  |:.:...:..:|  |...:|..|
Frog   413 EEDPKTASQSL-LVNLRAMQNFLQLP----EAERDRIYQ--DERERSLNAASTMGPTPLISTPT- 469

  Fly   720 ERHRSSPLMDEDEDEAGEQQQPQEAKSDGMNGSVKDEERQEKSRDELQD---------------- 768
                |.|...:....|.|:....|..:..:|.|:.||.:||..|.::..
Frog   470 ----SRPSQVKTTTIATERNGNLENCTMNINASIYDEIQQEMKRAKVSQALFAKVAASKSQGWLC 530

  Fly   769 ---NEKENSNGEDRHL----------------DADAQMEASSNLNNNHNNSSLHI---------- 804
               ..||:.:.|:|.|                :.|...|..||..:.|:....|:
Frog   531 ELLRWKEDPSPENRTLWENLSMIRRFLSLPQTERDVIYEQESNAVHQHSERPSHVIHVSAEQIQQ 595

  Fly   805 ---EQEVGSTPK----RSTPKEEDDDLDMDEDEEDNEN-------DASHLDEFRSPSPDLAGGVV 855
               :|:....|:    |..|::.......:.:||:.:.       ....|...:|...|:  |:.
Frog   596 QQQQQQQQQQPQPLGPRLPPRQPTVASPAESEEENRQQPRPRTKISVEALGILQSFIQDV--GLY 658

  Fly   856 PHKD-------QLPFPMVPNSMFSQSFMYMSHYIPAFGQAAAGHPHHHAAAAAAAAGIQPNALMG 913
            |.::       ||..|......|.|:..|   |:           .||            ..|..
Frog   659 PDEEAIQTLSAQLDLPKYTIIKFFQNQRY---YL-----------KHH------------GKLKD 697

  Fly   914 GGGLNLSSISNEERRKRNRTFIDPVTEVPKLEQWFAMNTHPSHNLILKYTEDL 966
            ..||.:.....::.            |:||..:..|.:...|....:|..|||
Frog   698 NSGLEVDVADYDDE------------ELPKDSEEIAQDKCTSTLFPVKLEEDL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dve	NP_477242.1	SATB1_N	252..358	CDD:211426	28/105 (27%)
		HOX	556..623	CDD:197696	12/81 (15%)
		PPP4R2	<644..778	CDD:286293	32/157 (20%)
		HOX	928..995	CDD:197696	9/39 (23%)
satb1	NP_001093671.1	SATB1_N	75..170	CDD:211426	28/105 (27%)
		CUTL	177..247	CDD:318706	17/77 (22%)
		PAT1	<262..>368	CDD:330585	23/142 (16%)
		CUT	373..444	CDD:308148	19/87 (22%)
		CUT	490..567	CDD:308148	13/76 (17%)
		HOX	633..690	CDD:197696	12/72 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10292
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47589
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4065
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030