DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco1c1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_445893.1	Gene:	Slco1c1 / 84511	RGDID:	628660	Length:	716	Species:	Rattus norvegicus

Alignment Length:	771	Identity:	201/771 - (26%)
Similarity:	321/771 - (41%)	Gaps:	167/771 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GKSYDKEKEAGNQDGEETTPKTGKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTCGFWIFKGT 102
            |.|:    :||....||..|..||.|                                  :|.|.
  Rat    22 GPSF----KAGYPSTEEARPCCGKLK----------------------------------VFLGA 48

  Fly   103 F-YQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAV 166
            . :..||.               ::|..|...|||.||:||.|||...|||....:|...||...
  Rat    49 LSFVYFAK---------------ALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITF 98

  Fly   167 LAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFL-----------YGPGEDALALTSEFGGMPDE 220
            ::|:..|.|||:.||.|.|.:.|..:|...|.|.           |.|..:   ||........|
  Rat    99 VSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSN---LTPNISPCYLE 160

  Fly   221 NATMEAIEEQRS---KTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDD 282
            :::    ...||   |:..::|.   |||| :.:.:..:.:|:...:.|:|.:....||::|:||
  Rat   161 SSS----PSPRSIVGKSQNKIND---ECEV-DTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDD 217

  Fly   283 NTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWL 343
            ...:......:.....:.::||..|:.|.|.|.:||:    ....|..|..|||:|:||||||:|
  Rat   218 FASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYL 282

  Fly   344 VMGGLLSFSGVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKAS 408
            :.|.|...:.|.....||.|||:.:|.  :.....||.:.........::....:.....|....
  Rat   283 IAGFLSLLAAVPFWCLPKTLPRSQSRE--DSGSSSEKSKFITDDPVNYQMAPREESMKIMEMARD 345

  Fly   409 FQDMLKTFRRLITNKTYMCNT---LSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVAL 470
            |...||:..|......|:|.:   .:|:|.:|.|      .|||||.||.||::.::.|.|.:.:
  Rat   346 FLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTY------KPKYIEQQYGQSSSKANFVIGLINI 404

  Fly   471 AFSAVGVLLSGFIISRYK---PRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVI------- 525
            ...|:|:...|.::.:::   ..|..:...:.:.|:|....:.|   :||  ..|||.
  Rat   405 PAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFA---LGC--ENSSVAGLTVSYQ 464

  Fly   526 ----VNIHDSSLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKK-IFYD 585
                |:.|:.:|..:   |||.|.|...::.|:||:|.:||.|||.|||:.  .:..||. ||.:
  Rat   465 GTKPVSYHERALFSD---CNSRCKCSDSKWEPMCGDNGITYASACLAGCQS--SSRSGKNIIFSN 524

  Fly   586 CSCI----PSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVN--CWTQ 644
            |:|:    |..                                   .|...|.|.|..:  |...
  Rat   525 CTCVGFAAPKS-----------------------------------GNWSGMMGRCQKDNGCSQM 554

  Fly   645 FVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRV 709
            |:.||.:.....:..:.|....:::.:||:..:.|:.|:|.......:||.||:|::||.:.|..
  Rat   555 FLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTS 619

  Fly   710 CLVWG-KTCTNKGNCWLYDPLSMRY------TLNFTAAVFIAIGAIFDLGVWYYAK 758
            ||.|| |.|.::|:|.|||..:.|:      ||..|.:||::...:..|...|.:|
  Rat   620 CLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSTAVLLVLKKKYVSK 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	178/661 (27%)
		MFS	114..>518	CDD:119392	114/427 (27%)
		KAZAL_SLC21	537..590	CDD:238650	23/57 (40%)
Slco1c1	NP_445893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/7 (29%)
		OATP	44..642	CDD:281175	182/676 (27%)
		MFS	46..>459	CDD:119392	121/451 (27%)
		KAZAL_SLC21	476..529	CDD:238650	24/57 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820