DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco6c1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_083218.1	Gene:	Slco6c1 / 74441	MGIID:	1921691	Length:	706	Species:	Mus musculus

Alignment Length:	824	Identity:	176/824 - (21%)
Similarity:	302/824 - (36%)	Gaps:	198/824 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LNNGKSYDKE-----KEAGNQDGEE----------TTPKTGKS-----KKKKQKSEQDRLMTAEI 79
            :.|.||.||:     ||..|:...|          |.|...|.     |:||..:..:.|:....
Mouse     4 VRNKKSDDKKAMVVAKEDTNKSESEGVTKLQTYLKTIPIAKKKFAKLPKRKKSPTSAELLLIDPR 68

  Fly    80 NKLLAESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKI 144
            .....|.||      |.......|.|||.|...::.||.....|....:|..:.|:...:.:|.:
Mouse    69 YSASKEGPL------GLGPIVLPFVQRFNNIDGFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSL 127

  Fly   145 PSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYG---PGED 206
            ......::...:.|:..:|:.::|::..||:|.|||....:.:....:|...|.|.|.   ||..
Mouse   128 TRTEWYLMDFSDYIASFVVAIIIAHFGSKGNRTRWIAASCILMGLESMLFAFPFFTYEIIIPGRQ 192

  Fly   207 ALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAP---QLLLF--VAQFISG 266
            ::.|..|              |.::...:|             ||..|   :.:.|  ..|.|.|
Mouse   193 SIELCME--------------ENEKRNIIC-------------GNSVPNRSKCIYFHIAGQCIHG 230

  Fly   267 IGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKD 331
            |.|...|.||::::.|:...|.....|::.:...::|..:|....   |:.:..|.....:..:.
Mouse   231 IAGMPIYILGITFIFDHIPTSSCGFYLAIGHSAYLIGYLLGMVGG---LQNFQPPPKEKTVEIEP 292

  Fly   332 PR----WLGAWWLGWLVMGGLLSFSGVFLSM-FPKELPRAVARRKVEENRRREKERLSVKSTEKE 391
            .:    ....||..:|::.. :||...|:.: ||..||.|   .|:...:|:|      ..|...
Mouse   293 AKVYQLLQSGWWKTFLIIAA-ISFCVSFMMVCFPTSLPGA---HKLRLAKRKE------PPTIDR 347

  Fly   392 RLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQ 456
            ||.   |.|.....|.    .|.....::.|...:...:..:...:.:.....|.|.:::.|:..
Mouse   348 RLK---DMKIQPHLKG----FLHNIWHILKNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLI 405

  Fly   457 SAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPGNE 521
            :...:|::||...|....:|..|.|.|:.|.:...:....:.::...::|...|...|:.|   :
Mouse   406 TPGIASLLTGAFVLPGGIIGHFLGGLIVDRLEMTNKNKLKFTLVTTVVSVGLFLLIFFVEC---Q 467

  Fly   522 SSVIVNIHD-----SSLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKK 581
            ::....|::     ..|...|..||..|.|....|:.:||.:...|.|.|.||||...| |:.:|
Mouse   468 TTTFAGINEDYDGYGQLGNLTADCNEYCDCTTSLYTSICGRDEKEYFSPCFAGCKATKV-SQTEK 531

  Fly   582 IFYDCSCI-----PSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNC 641
            .:|:||||     .|||.|    ||                      ::|:|      |.|..:|
Mouse   532 TYYNCSCIKEGLAASDDEG----QF----------------------IDAIA------GTCDSDC 564

  Fly   642 --WTQFVAF------LAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPS 698
              ...|.||      .:.||.:..:.         :.::.||....:.::|....:...:|.:|:
Mouse   565 LKLPLFFAFYFSATVFSNMCSIPVIS---------IILQSVPANFTSLSLGVTYAIVKFVASVPA 620

  Fly   699 PIFFGWVFDRVCLVW-GKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVW-------- 754
            |:.|.......|:.| ...|..|..||:|:...:.|..               :|:|
Mouse   621 PLLFRLSSAIACIYWDNNRCGGKERCWIYNKNILVYEF---------------MGIWMSSQLIIV 670

  Fly   755 ---YYAKDLKIFD--------------EDVKEVEMKIVQHEEEA 781
               .||  ::|.|              :||||      |.|.:|
Mouse   671 LLNIYA--IQIHDVVVHGEITESKTTVKDVKE------QKERKA 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	137/650 (21%)
		MFS	114..>518	CDD:119392	81/416 (19%)
		KAZAL_SLC21	537..590	CDD:238650	23/57 (40%)
Slco6c1	NP_083218.1	OATP	95..654	CDD:281175	137/650 (21%)
		MFS	97..>463	CDD:119392	80/412 (19%)
		KAZAL_SLC21	487..540	CDD:238650	22/53 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810