Protein Alignment Oatp58Dc and SLCO1A2

DIOPT Version :10

• Sequence 1: NP_611659.2
• Gene: Oatp58Dc / 37545
• FlyBaseID: FBgn0034716
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_066580.1
• Gene: SLCO1A2 / 6579
• HGNCID: 10956
• Length: 670
• Species: Homo sapiens
• Alignment Length: 681
• Identity: 177/681 - (25%)
• Similarity: 287/681 - (42%)
• Gaps: 140/681 - (20%)

  Fly   120 VGCIF---SMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIG 181
            :.|.|   :::.:|.|..:|.||::|.||:...|.|:...:|...|:...::|:..|.|||..||
Human    26 ITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIG 90

  Fly   182 FGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNG------ 240
            .|.:.:...|.|.:.||||....|  ...|....|....|:           .||..||
Human    91 IGCVVMGLGCFLKSLPHFLMNQYE--YESTVSVSGNLSSNS-----------FLCMENGTQILRP 142

  Fly   241 --GGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLG 303
              ..:|| ..|......:.:.|...:.|:|.:....||:||::|..|...:|..:.|.....::|
Human   143 TQDPSEC-TKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIG 206

  Fly   304 PAIGYALASFCLRLYIAPQM----HPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELP 364
            |.||..|||||..:|:....    ..:|...|.||:||||.|:|:..|:...:.:.....|..||
Human   207 PLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLP 271

  Fly   365 RAVARRKVE--ENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMC 427
            :.......:  :|...:|::..||. ||..:|               :|.|...:.|..|..||.
Human   272 KEGLETNADIIKNENEDKQKEEVKK-EKYGIT---------------KDFLPFMKSLSCNPIYML 320

  Fly   428 NTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYK---P 489
            ..|.|:.....:.....|.|||:|.||..|::.:..:.|...|....:|.::.|.|:.::|   .
Human   321 FILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVK 385

  Fly   490 RARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGNTTT--------------- 539
            :|.::..|      |::...|.| |:       |.::...:||:.|..|:
Human   386 QAAHIGCW------LSLLEYLLY-FL-------SFLMTCENSSVVGINTSYEGIPQDLYVENDIF 436

  Fly   540 --CNSACSCDYVRYSPVCGENNMTYISACHAGCKKLL---VNSEGKKIFYDCSCIPSDDAGNSTS 599
              ||..|:|....:.||||.|.::|:|||.|||:..:   :|    .:|.:||||.:  :|||:
Human   437 ADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGIN----MVFQNCSCIQT--SGNSS- 494

  Fly   600 QFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP--VNCWTQFVAFLAVMCCLKFVGASG 662
                                            |:.|.|.  .:|......||.:.....|:.:..
Human   495 --------------------------------AVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLA 527

  Fly   663 RASNFLVSVRCVPEKDKTAAMGFGM-TLCS-MLAFIPSPIFFGWVFDRVCLVWGK-TCTNKGNCW 724
            ....::|.:||:..::|  ::|.|: |.|: :.|.||:||:||.:.|..||.||. .|...|.|.
Human   528 AIPGYMVLLRCMKSEEK--SLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACR 590

  Fly   725 LYDPLSMRYTL----------NFTAAVFIAI 745
            :||..:.||..          :|..|:.|.|
Human   591 IYDSTTFRYIYLGLPAALRGSSFVPALIILI 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_611659.2	OATP	113..731	CDD:460821	171/655 (26%)
SLCO1A2	NP_066580.1	oat	1..625	CDD:273279	177/681 (26%)