Protein Alignment Oatp58Dc and SLCO2A1

DIOPT Version :9

• Sequence 1: NP_001097409.1
• Gene: Oatp58Dc / 37545
• FlyBaseID: FBgn0034716
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_005621.2
• Gene: SLCO2A1 / 6578
• HGNCID: 10955
• Length: 643
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 192/683 - (28%)
• Similarity: 308/683 - (45%)
• Gaps: 164/683 - (24%)

  Fly   107 FANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYA 171
            |.|...:||..|::.....:..|||..::|||||||.:.|.::|:||..|:||..::...::|:.
Human    28 FGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFG 92

  Fly   172 GKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLC 236
            .:.||||.||.|.|.:.....:.|.||||..|.:..||.|.       .|:.::|       .||
Human    93 SRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTG-------NNSRLQA-------ELC 143

  Fly   237 RLNGGG---AECEVGEGNFAPQL-------LLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPA 291
            :.:...   ::|.....|  ||.       |:.|||.::|||.......|:||:||.::.|.:|.
Human   144 QKHWQDLPPSKCHSTTQN--PQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPL 206

  Fly   292 LLSLSYFLRMLGPAIGYALASFCLRLYI--------APQMHPVINNKDPRWLGAWWLGWLVMGGL 348
            .:|:.:.:.:.|||.||.|.|..|::::        |..:.|    .||||:||||||.|:...|
Human   207 YISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVP----GDPRWIGAWWLGLLISSAL 267

  Fly   349 LSFSGVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDML 413
            |..:......||:.:|....|.....:..|:.|.                    |:::.|..|.:
Human   268 LVLTSFPFFFFPRAMPIGAKRAPATADEARKLEE--------------------AKSRGSLVDFI 312

  Fly   414 K----TFRRLITNKTYM------CNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTV 468
            |    .|.||:.|..::      | |.||:  :.|.:   .|..|::|.||..|||.::.:.|.|
Human   313 KRFPCIFLRLLMNSLFVLVVLAQC-TFSSV--IAGLS---TFLNKFLEKQYGTSAAYANFLIGAV 371

  Fly   469 ALAFSAVGVLLSGFIISRYK------PRARYMAAWNVIVGFLTVAGILAYA--FIGC-------- 517
            .|..:|:|:|..|.::.|:.      ||        :....:|::.||...  |:||
Human   372 NLPAAALGMLFGGILMKRFVFSLQAIPR--------IATTIITISMILCVPLFFMGCSTPTVAEV 428

  Fly   518 -PGNESSVIVNIHDSSLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKK 581
             |.:.||   :||..|.|     |...|||....:.||||:|.:.|:|.|||||..:.::|...|
Human   429 YPPSTSS---SIHPQSPA-----CRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSK 485

  Fly   582 --IFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQ 644
              |:.:|||:    .|.|.|                                |..|:|||.| ..
Human   486 QLIYLNCSCV----TGGSAS--------------------------------AKTGSCPVPC-AH 513

  Fly   645 F-------VAFLAVMCCLKFVGASGRASN--FLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPI 700
            |       ::|::::.|:        :.|  :::.:|.|.:::|:.|:|....|..:||::|||.
Human   514 FLLPAIFLISFVSLIACI--------SHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPA 570

  Fly   701 FFGWVFDRVCLVWGKTCT-NKGNCWLYDPLSMR 732
            .:|...|..|:.|...|. .:|.|..||..::|
Human   571 LYGLTIDHSCIRWNSLCLGRRGACAYYDNDALR 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	189/675 (28%)
		MFS	114..>518	CDD:119392	127/448 (28%)
		KAZAL_SLC21	537..590	CDD:238650	22/54 (41%)
SLCO2A1	NP_005621.2	oat	1..630	CDD:273279	192/683 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750