DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Dc and Gm5724

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001365611.1	Gene:	Gm5724 / 435927	MGIID:	3643685	Length:	670	Species:	Mus musculus

Alignment Length:	737	Identity:	197/737 - (26%)
Similarity:	314/737 - (42%)	Gaps:	152/737 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 VLLYGIVG-CIF-SMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHR 176
            |.|..:.| |:. |:|.::....:..||::|.:.:...|:|:....:...||...::|:..|.||
Mouse    21 VFLLALTGACVSKSLTGSHMKSMLLQIERQFGLLTSTVGLITGSFSMGMLLVIIPVSYFGTKLHR 85

  Fly   177 PRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAI--EEQRSKTLCRLN 239
            |..||.|.:.:...|.:.:.||||.|..|....::      |..|.:..:.  .|.||.|| :..
Mouse    86 PIMIGVGCMFMGLGCFIISLPHFLMGRYEYETTIS------PTSNLSSNSFLCMENRSLTL-KPT 143

  Fly   240 GGGAECEVGEGNFAPQLL---LFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPAL-------LS 294
            ....||    |.....|:   :.|...|.|:|.:....||:||::|..|...:|..       ::
Mouse   144 QDTTEC----GREIKSLMWIYVLVGNIIRGMGETAIMPLGISYIEDFAKSENSPLYIGILEIGIT 204

  Fly   295 LSYFLRMLGPAIGYALASFCLRLYIAPQM----HPVINNKDPRWLGAWWLGWLVMGGLLSFSGVF 355
            :||:       |||:|.|||..:|:....    ...|...|.||:||||:|:||..|:...:.:.
Mouse   205 ISYW-------IGYSLGSFCANIYVDTDSGNTDDLTITPTDTRWVGAWWIGFLVCAGVNFLTSIP 262

  Fly   356 LSMFPKELPRAVARRKVE--ENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRR 418
            ...|||.||:...:...:  ||.:.||.|...|. |.:|:               .:|.....:.
Mouse   263 FFFFPKTLPKEGLQDNGDGTENAKEEKHREKAKK-ENQRI---------------IKDFFPLMKN 311

  Fly   419 LITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFI 483
            |..|..||...|.|:.....:.....:.|||:|.||.:|:|....:.|...|....:|.||.|.|
Mouse   312 LSCNPIYMLYLLISVLQFNTFVSMVSYVPKYLEQQYGKSSADVLFIMGIYMLPPICLGYLLGGLI 376

  Fly   484 ISRYK---PRARYMAAWNVIVGFL-------------TVAGILA-YAFIGCPGNESSVIVNIHDS 531
            :.::|   .:|.|:|....:..:|             .|||:.| |..:..|       :::...
Mouse   377 MKKFKITAKKAAYIAFCLSLTDYLLSLSNYMTNCDSFQVAGLTASYEGVQHP-------LHVDHE 434

  Fly   532 SLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGN 596
            .||    .||:.|||....:.||||.|.:.|:|||.|||:|.:.|.. ..:|.:||||.|  :||
Mouse   435 VLA----DCNTRCSCLTNTWDPVCGNNGLAYMSACLAGCEKSVGNGI-NMVFQNCSCIRS--SGN 492

  Fly   597 STSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGAC---PVNCWTQFVAFLAVMCCLKFV 658
            |:                                 |:.|.|   | :|......|:.:.....|:
Mouse   493 SS---------------------------------AVLGLCNKGP-DCDNMLKYFIIIFSVKMFI 523

  Fly   659 GASGRASNFLVSVRCVPEKDKTAAMGFGM-TLCS-MLAFIPSPIFFGWVFDRVCLVWGK-TCTNK 720
            .:......::|.:||:..::|  ::|.|: |.|: :.|.||:||:||.:.||.||.||. .|..|
Mouse   524 FSLSSIPGYMVLLRCMKPEEK--SLGVGLHTFCTKIFAGIPAPIYFGALIDRACLHWGTLKCGEK 586

  Fly   721 GNCWLYDPLSMRYTL----------NFTAAVF-IAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKI 774
            ..|.:||..|.||..          ::..||| :.:...|.|     .:|..  ..|.:..|.|:
Mouse   587 AACRIYDINSFRYLFFGLPAALTGSSYLPAVFLLRLMRTFQL-----PEDTD--SPDTELAETKL 644

  Fly   775 VQHEEEANN-------EKNTEI 789
            ::.|.:..:       |.|.|:
Mouse   645 IEKENDCTDVHRSPKFESNGEM 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	181/659 (27%)
		MFS	114..>518	CDD:119392	117/440 (27%)
		KAZAL_SLC21	537..590	CDD:238650	23/52 (44%)
Gm5724	NP_001365611.1	oat	1..624	CDD:273279	187/686 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820