DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco4c1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001002024.2	Gene:	Slco4c1 / 432363	RGDID:	1303048	Length:	724	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	207/765 - (27%)
Similarity:	337/765 - (44%)	Gaps:	138/765 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ENPSSLGAELQDLEHGRRESRDESDVESRLL----NNGKSYDKEKEAGNQDGEETTPKTGKSKKK 65
            |||:.:.:   ..:..||.|...|.||...:    .||.|..:|.|    |.:::|..:..|...
  Rat     8 ENPAFVPS---SPDTPRRASASPSQVEVSAVASRNQNGGSQPRESE----DPQKSTEPSPPSSTL 65

  Fly    66 KQKSEQDRLMTAEINKLLAESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYA- 129
            ....|......:|    |.|.|      ||:..|.....||..|...::|.|    |:.::|..
  Rat    66 PASDEPPGSQLSE----LEEGP------CGWRNFHPQCLQRCNNPKGFLLHY----CLLALTQGI 116

  Fly   130 YFNG----TITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFF 190
            ..||    :|:|||||:::.|..||:||...|||..::|..::::..:||:|||:.|....|...
  Rat   117 VVNGLVNISISTIEKRYEMKSSLTGLISSSYDISFCVLSLFVSFFGERGHKPRWLAFASFMIGLG 181

  Fly   191 CILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQ 255
            .::.:.|||..|        ..|.|.:.::..               |......|.......:..
  Rat   182 ALVFSLPHFFSG--------RYELGTIFEDTC---------------LTRNSTRCASSTSLLSNY 223

  Fly   256 LLLFV-AQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYI 319
            ..:|| .|.:.|.||:..||||.:::||:....|:...:.:.|.:.:|||||||.|....|.:||
  Rat   224 FYVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIGIGYSMSILGPAIGYVLGGQLLTMYI 288

  Fly   320 --APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVF-LSMFPKELPRAVARRKVEENRRREKE 381
              |......:...|||||||||:|:| :..|.::|.:. .|.|||.||   ...|::..:
  Rat   289 DVAMGQSSDLTEDDPRWLGAWWIGFL-LAWLFAWSLIMPFSCFPKHLP---GTAKIQAGK----- 344

  Fly   382 RLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTF-----------RRLITNKTYMCNTLSSIFY 435
                        |::..|..:    .|||.|.:.|           :.|:.|..::|..||:...
  Rat   345 ------------TSQTHQNNS----TSFQHMDENFGKSIKDFPTAVKNLMRNTVFICLVLSTTSE 393

  Fly   436 LVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVI 500
            .:..|.:..|.||:||.|:..:::.::.:.|.|.:..:|:|.:|.|.::|::|.:.:     |.:
  Rat   394 ALVTTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGVLVSKFKMKCK-----NTM 453

  Fly   501 VGFLTVAGI---LAYAFI--GCP-GNESSVIVNIHDSSLAGN-TTTCNSACSCDYVRYSPVCGEN 558
            ...|..:|:   |::.||  .|. |..:.|..:.:.:...|| |..||:.|:|....|.|:||.:
  Rat   454 KFALCTSGVALMLSFVFIYAKCENGPFAGVSESYNGTGEMGNLTAPCNANCNCLRSYYYPLCGSD 518

  Fly   559 NMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQ 623
            .:.|.|.|.|||...:.|.: .|.:|:||||                         .:...:.|.
  Rat   519 GVQYFSPCFAGCLNSVSNRK-PKAYYNCSCI-------------------------ERKVDITST 557

  Fly   624 LEALANGQAMPGACPVNCWTQFVAFLAV-MCCLKFVGASGRASNFLVSV-RCVPEKDKTAAMGFG 686
            .|: .:.:|..|.|...| :....||.: ...:.|...:|  :...||: |||..:.::.|:|..
  Rat   558 AES-PDFEARAGKCKTQC-SNLPIFLGIFFITVIFTFMAG--TPITVSILRCVNHRQRSLALGVQ 618

  Fly   687 MTLCSMLAFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYTL 735
            ..|..:|..||.||.||...|..|::|. ..|..||.||:||.:.|.:.|
  Rat   619 FMLLRLLGTIPGPIIFGVTIDSTCVLWDINECGTKGACWIYDNIRMAHML 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	177/648 (27%)
		MFS	114..>518	CDD:119392	115/428 (27%)
		KAZAL_SLC21	537..590	CDD:238650	21/52 (40%)
Slco4c1	NP_001002024.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		20/83 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810