DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Dc and Oatp74D

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001163460.1	Gene:	Oatp74D / 39954	FlyBaseID:	FBgn0036732	Length:	819	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	234/767 - (30%)
Similarity:	362/767 - (47%)	Gaps:	116/767 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NGKSYDKEKEAGNQDGEETTPKTGKSKKKKQKSEQDRL-MTAEINKLLAESPLEKNVTCGFWIFK 100
            ||.|. .||.|     .|..|.||..|...:.||.:.. ..:::|   ..|..|.:.:||.:..:
  Fly   108 NGHSL-SEKYA-----HEQAPLTGGYKLPPRSSESEESDFDSDLN---GGSSAESSSSCGLFGCR 163

  Fly   101 GTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSA 165
            ..:.:|||:...:::::.:...:..|...||...||||||.|:|.||.|||:...:::.|...:.
  Fly   164 PRWARRFASTHVFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAM 228

  Fly   166 VLAYYAGKGHRPRWIGFGLLTI---VFFCILTTAPHFLYGPGEDAL---ALTSEFGGMPDENA-- 222
            :|.|:||:|||||||..|::..   .|.|.|   |||::  ||..:   .:..:....|..|:
  Fly   229 LLTYFAGRGHRPRWIACGMVLFSIAAFSCAL---PHFIF--GEQLMHSSVILQQTQVSPPNNSFS 288

  Fly   223 --TMEAIEEQRSKTLCRLNG----GGAECEVGEGNFAPQL--------------LLFVAQFISGI 267
              .:.|..||.:..||.|.|    .|:||     |...||              :.|.:...|||
  Fly   289 SHWLNASSEQVNPNLCILGGNQTHSGSEC-----NEERQLEQASHSKITVIVLCIFFGSLLSSGI 348

  Fly   268 GGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDP 332
            |.:...|||:.|:|||....::|..::::..:|:||||.|:...|||.|.|: ...:|..:..||
  Fly   349 GQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGSFCTRWYV-NFSNPGFDATDP 412

  Fly   333 RWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAEL 397
            ||:||||||.:.:|.|:..:.:.:..|||:|     |.|.:...:.......|:..||.:|
  Fly   413 RWIGAWWLGPVAIGSLMLLASIAMFSFPKQL-----RGKQKPPGQTATPAAPVEPEEKPKL---- 468

  Fly   398 DQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSS 462
                        :|..||.||.::|...|..|.|.:|:|:.....:.|.|||:|.|:|.:...::
  Fly   469 ------------KDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDAN 521

  Fly   463 MVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVN 527
            |:.....:....:|:::||..|.:.||.||.:|||......:..||::...||||..|:.:....
  Fly   522 MIAAFCGILVMGIGIVISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFIGCSMNDFAGYKP 586

  Fly   528 IHDSSLAGNTTTCNSA--CSCDYVRYSPVCGENNMTYISACHAGC-KKLLVNSEGKKIFYDCSCI 589
            ...:|.|....||::|  |:||...::|:|.:..| ||||||||| ...|..|:.:.::.||:||
  Fly   587 SDGNSPALIEPTCSAALNCTCDKENFAPICADGKM-YISACHAGCSSSSLRPSDNRTLYSDCACI 650

  Fly   590 PSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQFVAFLAVMCC 654
            |  ||                                   .:|:.|.|..|| ..|:.|:.:...
  Fly   651 P--DA-----------------------------------PEAVNGYCDNNC-KNFIYFILIFAI 677

  Fly   655 LKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTN 719
            ..|:.::....:.|:.:||...|||..|||...:...:...:|.||.:|.|.|..||:|...|..
  Fly   678 CVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFGNVPCPIIYGAVVDSACLIWKSVCGK 742

  Fly   720 KGNCWLYDPLSMR-YTLNFTAAV-FIAIGAIFDLGVWYYAKDLKIFDEDVKE 769
            .|.|.|||..:.| |.|..||.: |:|.  :.||.||..|..:.|..||.:|
  Fly   743 HGACSLYDADTFRQYFLGITAGIMFLAF--LMDLVVWRKAHRIDIAPEDPQE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	197/649 (30%)
		MFS	114..>518	CDD:119392	134/431 (31%)
		KAZAL_SLC21	537..590	CDD:238650	23/55 (42%)
Oatp74D	NP_001163460.1	OATP	175..754	CDD:335235	197/649 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6305
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
	9	8.700