DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Oatp58Db

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	361/747 - (48%)
Similarity:	482/747 - (64%)	Gaps:	84/747 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KEKEAGNQDGEETTPKTGKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTCGFWIFKGTFYQRF 107
            |:||||                         :..|:..|.|..|    :.||||.||:|...|||
  Fly    13 KDKEAG-------------------------INVADDEKRLNSS----DTTCGFSIFRGPALQRF 48

  Fly   108 ANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAG 172
            |....:|::|||..|..:|.:.||.|||||:||||.||:|.:|:|:||||||....||.|:|||.
  Fly    49 ATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYAS 113

  Fly   173 KGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLCR 237
            :||||||:..||:.|..||:|...||..|||||:||.||.|:|......|::...|  ::.:||
  Fly   114 RGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGMSESFGASLNITE--KNDSLC- 175

  Fly   238 LNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRML 302
             :...:.|....|::.|.:|.|:||||.|||.||:|..|:||||||:..|||||:||.|.|||||
  Fly   176 -HEKNSNCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRML 239

  Fly   303 GPAIGYALASFCLRLYIAPQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAV 367
            |||:|:::.|.||||||.|...|:|...||||:||||:||:::..:|:.|.||:.|||||:|||.
  Fly   240 GPAMGFSMVSLCLRLYIDPFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRAK 304

  Fly   368 ARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSS 432
            |||              :|:..:|.:..         |..||||||.:.:||.:||.|:.|.|:|
  Fly   305 ARR--------------LKADGEEDIPL---------AGRSFQDMLDSLKRLASNKVYVYNMLAS 346

  Fly   433 IFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAW 497
            |.||.||.|||||||||||:||||||:||:|.|||.||.|||.|:|:||::||:|||.||.||||
  Fly   347 ILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAW 411

  Fly   498 NVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGNTTTCNSACSCDYVRYSPVCGENNMTY 562
            |.:|.:|||||:|.|..:||..::.:     :..|:.....:|:::|.|:||.|:|||...|:|:
  Fly   412 NFVVDYLTVAGMLCYVLVGCDESDRA-----NSLSIVPTGDSCSASCVCEYVYYAPVCSPENITF 471

  Fly   563 ISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEAL 627
            ||||||||....:|..||.|:..|.|:     ||.:|      ...|||     .||:.||.:.
  Fly   472 ISACHAGCTDKAINELGKTIYTGCRCM-----GNVSS------IISLSN-----VTSLASQSQI- 519

  Fly   628 ANGQAMPGACPVNCWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSM 692
                ||.|||||:|..||:.||||||.||||||:||:||.|:::||||.||||.::|||..:.|:
  Fly   520 ----AMDGACPVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSV 580

  Fly   693 LAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVWYYA 757
            ||||||||.|||:.|..||||||||::|||||:||..|:|||:|...|..|.:|:.:::||||:|
  Fly   581 LAFIPSPIVFGWMLDSYCLVWGKTCSSKGNCWIYDTKSLRYTMNLVCASLIFLGSFWNIGVWYHA 645

  Fly   758 KDLKIFDEDVKEVEMKIVQHEEEANNEKNTEI 789
            ||:|:||||.|.|:.|  |.::....||..::
  Fly   646 KDMKVFDEDEKTVQAK--QSDDIELKEKPNDV 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	315/618 (51%)
		MFS	114..>518	CDD:119392	212/403 (53%)
		KAZAL_SLC21	537..590	CDD:238650	25/52 (48%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	315/618 (51%)
		MFS	55..>410	CDD:119392	199/381 (52%)
		KAZAL_SLC21	447..499	CDD:238650	25/56 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	1	1.000	-	-		FOG0012696
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
	9	8.860