DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and SLCO4C1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_851322.3	Gene:	SLCO4C1 / 353189	HGNCID:	23612	Length:	724	Species:	Homo sapiens

Alignment Length:	758	Identity:	200/758 - (26%)
Similarity:	333/758 - (43%)	Gaps:	153/758 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RRESRDESDVESRLLNNGKSYDKEKEAGNQDGEETTPKTGKSKKKKQKSEQDRLMTAEIN----- 80
            ||.|...|.:|...|    |.|.::       |.:.|:..:..::.|||.:..|.:|..|
Human    21 RRLSASPSQIEVSAL----SSDPQR-------ENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEK 74

  Fly    81 -KLLAESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYA-YFNG----TITTIE 139
             :.|:.|..|:. :.|:..|.....||......::|.|    |:.::|.. ..||    :|:|:|
Human    75 LRSLSLSEFEEG-SYGWRNFHPQCLQRCNTPGGFLLHY----CLLAVTQGIVVNGLVNISISTVE 134

  Fly   140 KRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPG 204
            ||:::.|..||:||...|||..|:|..::::..:||:|||:.|....|....::.:.|.|..|
Human   135 KRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSG-- 197

  Fly   205 EDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFV-AQFISGIG 268
                  ..:.|.:.::.              |........|.....:.:..|.:|: .|.:.|.|
Human   198 ------EYKLGSLFEDT--------------CVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAG 242

  Fly   269 GSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQM--HPVINNKD 331
            |:..||||.:::||:....|:...:...|.:.:|||||||.|....|.:||...|  ...:...|
Human   243 GTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDD 307

  Fly   332 PRWLGAWWLGWLVMGGLLSFSGVF-LSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTA 395
            ||||||||:|:| :..:.::|.:. .|.|||.||.                            ||
Human   308 PRWLGAWWIGFL-LSWIFAWSLIIPFSCFPKHLPG----------------------------TA 343

  Fly   396 ELDQKTTAEAKAS-------FQDMLKTF----RRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKY 449
            |:....|::|..|       |...:|.|    :.|:.|..:||..||:....:..|.:..|.||:
Human   344 EIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKF 408

  Fly   450 IEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGI---LA 511
            ||.|:..:::.::.:.|.|.:..:|:|.:|.||::|:::     |...|.:...|..:|:   |:
Human   409 IENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFR-----MTCKNTMKFALFTSGVALTLS 468

  Fly   512 YAFI--GCPGNESSVIVNIHDS-----SLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAG 569
            :.|:  .|   |:.....:.:|     .|......||:.|:|....|.||||: .:.|.|.|.||
Human   469 FVFMYAKC---ENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAG 529

  Fly   570 CKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMP 634
            |...:.:.: .|::|:||||                         .:.|.:.|..|.. ..:|..
Human   530 CSNPVAHRK-PKVYYNCSCI-------------------------ERKTEITSTAETF-GFEAKA 567

  Fly   635 GACPVNCWTQFVAFLAVMCCLKFV-----GASGRASNFLVSV-RCVPEKDKTAAMGFGMTLCSML 693
            |.|..:|     |.|.:..|:.|:     ..:|  :...||: |||..:.::.|:|....:..:|
Human   568 GKCETHC-----AKLPIFLCIFFIVIIFTFMAG--TPITVSILRCVNHRQRSLALGIQFMVLRLL 625

  Fly   694 AFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYTL 735
            ..||.||.||:..|..|::|. ..|..||.||:||.:.|.:.|
Human   626 GTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHML 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	175/655 (27%)
		MFS	114..>518	CDD:119392	114/428 (27%)
		KAZAL_SLC21	537..590	CDD:238650	20/52 (38%)
SLCO4C1	NP_851322.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..71		12/51 (24%)
		OATP	106..664	CDD:281175	175/655 (27%)
		MFS	124..>485	CDD:119392	111/419 (26%)
		KAZAL_SLC21	499..549	CDD:238650	21/76 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810