Protein Alignment Oatp58Dc and SLCO4C1

DIOPT Version :10

• Sequence 1: NP_611659.2
• Gene: Oatp58Dc / 37545
• FlyBaseID: FBgn0034716
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_851322.3
• Gene: SLCO4C1 / 353189
• HGNCID: 23612
• Length: 724
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 200/758 - (26%)
• Similarity: 333/758 - (43%)
• Gaps: 153/758 - (20%)

  Fly    21 RRESRDESDVESRLLNNGKSYDKEKEAGNQDGEETTPKTGKSKKKKQKSEQDRLMTAEIN----- 80
            ||.|...|.:|...|    |.|.::       |.:.|:..:..::.|||.:..|.:|..|
Human    21 RRLSASPSQIEVSAL----SSDPQR-------ENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEK 74

  Fly    81 -KLLAESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYA-YFNG----TITTIE 139
             :.|:.|..|:. :.|:..|.....||......::|.|    |:.::|.. ..||    :|:|:|
Human    75 LRSLSLSEFEEG-SYGWRNFHPQCLQRCNTPGGFLLHY----CLLAVTQGIVVNGLVNISISTVE 134

  Fly   140 KRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPG 204
            ||:::.|..||:||...|||..|:|..::::..:||:|||:.|....|....::.:.|.|..|
Human   135 KRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSG-- 197

  Fly   205 EDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFV-AQFISGIG 268
                  ..:.|.:.::.              |........|.....:.:..|.:|: .|.:.|.|
Human   198 ------EYKLGSLFEDT--------------CVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAG 242

  Fly   269 GSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQM--HPVINNKD 331
            |:..||||.:::||:....|:...:...|.:.:|||||||.|....|.:||...|  ...:...|
Human   243 GTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDD 307

  Fly   332 PRWLGAWWLGWLVMGGLLSFSGVF-LSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTA 395
            ||||||||:|:| :..:.::|.:. .|.|||.||.                            ||
Human   308 PRWLGAWWIGFL-LSWIFAWSLIIPFSCFPKHLPG----------------------------TA 343

  Fly   396 ELDQKTTAEAKAS-------FQDMLKTF----RRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKY 449
            |:....|::|..|       |...:|.|    :.|:.|..:||..||:....:..|.:..|.||:
Human   344 EIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKF 408

  Fly   450 IEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGI---LA 511
            ||.|:..:::.::.:.|.|.:..:|:|.:|.||::|:::     |...|.:...|..:|:   |:
Human   409 IENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFR-----MTCKNTMKFALFTSGVALTLS 468

  Fly   512 YAFI--GCPGNESSVIVNIHDS-----SLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAG 569
            :.|:  .|   |:.....:.:|     .|......||:.|:|....|.||||: .:.|.|.|.||
Human   469 FVFMYAKC---ENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGD-GVQYFSPCFAG 529

  Fly   570 CKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMP 634
            |...:.:.: .|::|:||||                         .:.|.:.|..|.. ..:|..
Human   530 CSNPVAHRK-PKVYYNCSCI-------------------------ERKTEITSTAETF-GFEAKA 567

  Fly   635 GACPVNCWTQFVAFLAVMCCLKFV-----GASGRASNFLVSV-RCVPEKDKTAAMGFGMTLCSML 693
            |.|..:|     |.|.:..|:.|:     ..:|  :...||: |||..:.::.|:|....:..:|
Human   568 GKCETHC-----AKLPIFLCIFFIVIIFTFMAG--TPITVSILRCVNHRQRSLALGIQFMVLRLL 625

  Fly   694 AFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYTL 735
            ..||.||.||:..|..|::|. ..|..||.||:||.:.|.:.|
Human   626 GTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHML 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_611659.2	OATP	113..731	CDD:460821	175/654 (27%)
SLCO4C1	NP_851322.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..71		12/51 (24%)
		MFS_SLCO4C_OATP4C	104..604	CDD:341021	153/597 (26%)