DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Oatp33Eb

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	709	Identity:	175/709 - (24%)
Similarity:	293/709 - (41%)	Gaps:	138/709 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 EKNVTCGF----WIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNT 149
            :.:|.||.    |. :|...|::|....::|:..|.|.:.....:||.  ::..:..|:. ..|.
  Fly    22 DDSVDCGIKGLGWC-RGPGCQKYARLRTFILVLAISGTLQGACESYFR--VSAKQASFQF-GWNP 82

  Fly   150 GIIS---VGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFL-YGPG---EDA 207
            .|:.   |.:.:.|.:.:...||:|...|..:|:...|:.....|::...|..: :..|   :||
  Fly    83 LIVDWLLVASGLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDA 147

  Fly   208 LALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLY 272
            |.         |.|....::.:.:..||       .|.:......|   :|||.|...|:||..|
  Fly   148 LL---------DANMCATSLAQFQRLTL-------TEAQSSSLTLA---MLFVLQLALGMGGLAY 193

  Fly   273 YTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPRWLG- 336
            |||||||:|||:....:||::..:...|:.|...|    ||.:                   ||
  Fly   194 YTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAG----SFLV-------------------LGV 235

  Fly   337 -----AWWLGWLVMGGLLSFSGVFLSMFPKELPRAV----ARRKVEENRRREKERLSVKSTEKER 392
                 .|||||:::...:....|.|.:|||.||:.|    |:|.:|::..|   |..      .:
  Fly   236 GLTHVGWWLGWVILAPFIFVGAVLLGLFPKRLPKTVIHQAAQRIIEQSSMR---RFG------SQ 291

  Fly   393 LTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIE----VQ 453
            .:..:|.          .|...:.:||..|:..|.|.||.:........|.:....|::    :.
  Fly   292 FSTYMDD----------SDFWPSLKRLFNNRLLMFNLLSIMCVQSAVVNYGLQEESYLQSRFFLP 346

  Fly   454 YRQS---AA--TSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYA 513
            |.:.   ||  .|:.|:..:.....|:|:|:||.:||:.|..||.:...|:.:....||..:...
  Fly   347 YNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLI 411

  Fly   514 FIGCPGNESSVIVNIHDSSLAGNTTTCNSACSCDYVRYSPVCGEN-NMTYISACHAGC-KKLLVN 576
            |:.|   :...|..:....|  ....|:|.|.|....:.|||.|| ::||.|.|:||| ||..:|
  Fly   412 FVQC---DVGAIAGVEGGKL--KQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTIN 471

  Fly   577 SEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPV-N 640
            |  .::|..||| ..|.:.|||.|.:                             |..|||.. |
  Fly   472 S--FQLFEGCSC-SGDQSLNSTGQMR-----------------------------ATAGACSSDN 504

  Fly   641 CWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWV 705
            |.:..:.|..:...:.|:...|.....|:::|.|..:||:.|:.|.:.:..:.|::|..:.:..|
  Fly   505 CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMIVGLFAYVPVHLSYDIV 569

  Fly   706 FDRVCLVWGKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFD 764
            ....|:.|   ..|...|.|.:.......|:...|..|....:||:.|:.:||.|.:::
  Fly   570 TRTTCVYW---APNYERCLLRETPKHGNILDILTASLILASVLFDILVYIFAKGLNLYN 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	159/647 (25%)
		MFS	114..>518	CDD:119392	103/429 (24%)
		KAZAL_SLC21	537..590	CDD:238650	24/54 (44%)
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	172/700 (25%)
		MFS	50..>267	CDD:119392	65/261 (25%)
		KAZAL_SLC21	430..483	CDD:238650	24/55 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840