DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Oatp26F

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_609055.2	Gene:	Oatp26F / 33927	FlyBaseID:	FBgn0051634	Length:	692	Species:	Drosophila melanogaster

Alignment Length:	775	Identity:	194/775 - (25%)
Similarity:	321/775 - (41%)	Gaps:	171/775 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TAEINKLLAESPLEKNVT----------------------------CGF---WIFKGTFYQRF-- 107
            |.|::..:|.:|...||.                            ||:   |:      |||
  Fly     5 TIELDSSIAVAPKCSNVNNNNSARSSRVGSSISGPDSDAECQRFGWCGWNPAWL------QRFCT 63

  Fly   108 ANQTAYVLLYG--IVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYY 170
            |....:.|.:|  :.|.|.:   ...|.:|:|||:||.:.|:..|:::.|.|::.......:.||
  Fly    64 AKWALFWLCWGGALQGLIVN---GLINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYY 125

  Fly   171 AGK--GHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTS--EFGGMP-DENATMEAIEEQ 230
            .|:  ..:||:|..||:.:....::...|:||.|.....:|..:  |..|:| :.|::
  Fly   126 GGRRGASKPRFIAIGLIVMGMGSLVFLLPNFLVGNYRATIAEANVCETTGLPFNSNSS------- 183

  Fly   231 RSKTLCRLNGGGAECEVGEG---NFAPQLLLFV-AQFISGIGGSLYYTLGVSYMDDNTKKSKTPA 291
            :|.|.|.||.      :|||   |....:.||: ||.:.|.|.|..:||||:|:|:|..|..:..
  Fly   184 QSMTACELNA------MGEGQSENLTWTVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSV 242

  Fly   292 LLSLSYFLRMLGPAIGYALASFCLRLYIA-PQMHPV---INNKDPRWLGAWWLGWLVMGGLLSFS 352
            .|.:.|.:..:||||||......|.:|.. ..:.||   :.:....|:||||||::....:....
  Fly   243 YLGIYYTMATVGPAIGYVFGGQLLLIYTDWMTVDPVQLSLTSDSKVWIGAWWLGFIFAAAMCLLI 307

  Fly   353 GVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFR 417
            .:.:..:||.||.|         .:.:.||:|    |.....:|.|..:..     .:.:.:...
  Fly   308 ALPIFGYPKLLPGA---------EKLQLERVS----EAHATISEADDSSNV-----VRGLPRAVL 354

  Fly   418 RLITNKTYMCNTLSSI---FYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLL 479
            .|:.|.|:....|:..   ..:.|:.   .|.||.||.|:..|...|::|.|.:.:.....|..|
  Fly   355 SLLANPTFFFLNLAGATEGLVIAGFA---AFLPKQIENQFSISPMYSALVMGLITVPAGGGGTFL 416

  Fly   480 SGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAF-IGCPGNESSVIVNIHDSSLAGNTT----- 538
            .|:::.::....|.:....::.  .|||.:....| :.||           :...||.||
  Fly   417 GGYLVKKWNLACRGIIKMCLLA--TTVAALFTICFLVSCP-----------NPKFAGVTTGYKMQ 468

  Fly   539 ----------TCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSE---GKKIFYDCSCIP 590
                      :|||.|.|....|.|:||.:.:.|.|.|:|||    |..|   ..|.:::||||.
  Fly   469 PSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPCYAGC----VQEEHANSLKRYHNCSCIE 529

  Fly   591 S----DDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWT--QFVAFL 649
            .    || ||.:|:...... |.:|.:                       |...|.|  .|||..
  Fly   530 QVGFVDD-GNPSSEAPHFRP-DATNRK-----------------------CDSTCQTLPLFVALC 569

  Fly   650 AVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWG 714
            .::....|:......|   .::|||.:..::.|:|.......:|..||:|:.||.:.|..|::|.
  Fly   570 FILMVFTFLATMPALS---ATLRCVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQ 631

  Fly   715 KTCTNK--GNCWLYDPLSM-RYTLNFTAAVFIAIGAI--FDLGVWYYAKDLKIFDEDVKE 769
            ::|...  |.|.:||...: ||.  :..|:...:|::  |....|:|....|..:.:.||
  Fly   632 ESCDKDAGGACLVYDNFYISRYM--WLLALICKLGSVVFFACAWWFYVPPSKPLNANGKE 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	171/663 (26%)
		MFS	114..>518	CDD:119392	109/422 (26%)
		KAZAL_SLC21	537..590	CDD:238650	23/70 (33%)
Oatp26F	NP_609055.2	OATP	66..647	CDD:281175	170/662 (26%)
		MFS	69..>318	CDD:119392	77/264 (29%)
		KAZAL_SLC21	476..529	CDD:238650	21/56 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446212
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840