DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco6c1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_775460.1	Gene:	Slco6c1 / 287006	RGDID:	708431	Length:	701	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	178/801 - (22%)
Similarity:	307/801 - (38%)	Gaps:	157/801 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LNNGKSYDKEKEAGNQDGE---------ETTPKT-----GKSKKKKQKSEQDRLMTAEINKLLAE 85
            :.|.|...|:.:..||:.|         .|.|..     |:.:||:..:..:.|:..:.: ...|
  Rat     4 VQNKKPDAKKDDKHNQETEGLKKIDTYLRTIPTVTKKFKGRPQKKRSPTSAELLLDPKYS-ASKE 67

  Fly    86 SP----------LEK--NVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTI 138
            .|          |::  |:.| |.||          ..|.||::|.:..:..|....::..:|..
  Rat    68 GPFGLGPLVFPCLQRFNNIDC-FMIF----------FIASVLIHGALFALADMILNLYHSLLTLS 121

  Fly   139 EKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGP 203
            ::.......:..|:|       :||:..:|::.|||:|.:||....:.:.|..||...|...|.
  Rat   122 KRELYFMDFSGYIVS-------SLVAIFVAHFGGKGNRTKWIAAACILMAFGSILLGFPFSKYE- 178

  Fly   204 GEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLF--VAQFISG 266
                   ..:.||...|    ..:||.:.:.:        .|.........:.:.|  :.|.::|
  Rat   179 -------IMKSGGQRVE----LCVEENKRRNI--------HCVTNSNPDRTKCICFFIIGQCLNG 224

  Fly   267 IGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKD 331
            |.|...|.||.:::.|:.........|:|.:...::    ||.|..|.....::|.....::..|
  Rat   225 IAGMPIYILGKTFILDHVPTRSAGFYLALGHSAHLM----GYFLGIFGGMKNLSPPPKEKLSAVD 285

  Fly   332 PRWLG-----AWWLGWLVMGGLLSFSGVFLSM--FPKELPRAVARRKVEENRRREKERLSVKSTE 389
            ...:.     .||..:|.:.. :||| |||.:  ||..||.|   .|::..:|:|      ..|.
  Rat   286 SAKIHLLLQFGWWKTFLFVAA-ISFS-VFLVLLCFPTSLPGA---HKLKLAKRKE------PPTF 339

  Fly   390 KERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQY 454
            .:||.   |||    .:..|:..:.....::.|...|...:..:.....:.....|.|.:::.|:
  Rat   340 DKRLK---DQK----IQPRFKGFVFAIWYMLRNPLLMTQAMCKVSESFAFHTSLEFLPYHLQTQF 397

  Fly   455 RQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPG 519
            ..:...:||:||...:....:|..|.|.|:.|.:...:....::::...::||..|...|:.|..
  Rat   398 SITPQIASMLTGLFVIPGGVIGHFLGGLIVDRLEMTNKNKLKFSLVTSVVSVALFLLIFFVECET 462

  Fly   520 NESSVIVNIHD--SSLAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKI 582
            .:.:.|...:|  ..|...|..||..|:|....||.|||.:...|.|.|.|||....| .:.:|.
  Rat   463 TKFAGINEDYDGLGKLGNLTAGCNYHCACTTSLYSSVCGRDEKEYFSPCFAGCSATKV-QQNEKT 526

  Fly   583 FYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANG---QAMPGACPVNCWT- 643
            :|:||||.           :.||:.|                   |:|   .|..|.|..||.|
  Rat   527 YYNCSCIK-----------EGLTTSD-------------------ADGHFIDATDGTCNSNCLTL 561

  Fly   644 -QFVAF------LAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIF 701
             .|.||      .:.||....:         |:.::.||....:...|..:.:....|.:|.|..
  Rat   562 PLFFAFYFSATVFSTMCSTPII---------LIILQSVPANFSSLGQGVTVAITKFTASVPEPAL 617

  Fly   702 FGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYT-----LNFTAAVFIAIGAIFDLGVWYYAKDL 760
            ||......|..|. ..|..:..||:|:..::.|.     ::|  .:|.|:..|:.:.::.|....
  Rat   618 FGTASSVACKFWDINACGVREKCWIYNKTTLVYVFIGIWVSF--KLFTALLNIYAIHIYDYVVKG 680

  Fly   761 KIFDEDVKEVEMKIVQHEEEA 781
            ||.|.....|:....|.|..|
  Rat   681 KISDSKTTHVKASKAQKERRA 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	145/641 (23%)
		MFS	114..>518	CDD:119392	86/412 (21%)
		KAZAL_SLC21	537..590	CDD:238650	22/52 (42%)
Slco6c1	NP_775460.1	OATP	88..648	CDD:281175	149/659 (23%)
		MFS	90..>457	CDD:119392	88/425 (21%)
		KAZAL_SLC21	481..534	CDD:238650	22/53 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810