DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco1a6

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001368859.1	Gene:	Slco1a6 / 28254	MGIID:	1351906	Length:	670	Species:	Mus musculus

Alignment Length:	717	Identity:	192/717 - (26%)
Similarity:	305/717 - (42%)	Gaps:	129/717 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 VLLYGIVGCIFS--MTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHR 176
            |.|..::....|  ::..|.:..:|.:|::|.|.:...|:|:...::...||...::|:..|.||
Mouse    21 VFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHR 85

  Fly   177 PRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAI--EEQRSKTLCRLN 239
            |..||.|...:...|.:.:.||||.|..|....::      |..|.:..:.  .|.||:|| :..
Mouse    86 PIMIGVGCAVMGLGCFIISLPHFLMGRYEYETTIS------PTSNLSSNSFLCVENRSQTL-KPT 143

  Fly   240 GGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGP 304
            ...||| |.|......:.:.|...|.|||.:....||:||::|..|...:|..:.:....:|:||
Mouse   144 QDPAEC-VKEIKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGP 207

  Fly   305 AIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPR 365
            .:||.:..||..:|:    .......|...|.||:||||:|:||..|:...:.:....|||.||:
Mouse   208 ILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPK 272

  Fly   366 AVARRKVE--ENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTF----RRLITNKT 424
            ...:...:  ||.:.||.|                    .:||...|.::|.|    :.|..|..
Mouse   273 EGLQDNGDGTENAKEEKHR--------------------DKAKEENQGIIKEFFLMMKNLFCNPI 317

  Fly   425 YMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKP 489
            ||...|:|:..:.|.....|:.|||:|..:..|.|.:..:.|.......:.|.|:||||:.:.|.
Mouse   318 YMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKI 382

  Fly   490 RARYMAAWNVIVGFLTVAGILAYAFI--GCPGNESSVIVNIHDSSLAGNTTT------------- 539
            .             |..|.|:|....  .|..:..:.::....:.:||.||:
Mouse   383 T-------------LKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGLTTSYEGIQQSFDMENK 434

  Fly   540 ----CNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQ 600
                ||:.|:|....:.||||.|.:.|:|.|.|||:| .|.:....:|.:||||.|  :|||:
Mouse   435 FLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEK-SVGTGANMVFQNCSCIRS--SGNSS-- 494

  Fly   601 FKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP--VNCWT--QFVAFLAVMCCLKFVGAS 661
                                           |:.|.|.  .:|..  |:...:.|.||  |..:.
Mouse   495 -------------------------------AVLGLCKKGPDCANKLQYFLIITVFCC--FFYSL 526

  Fly   662 GRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGK-TCTNKGNCWL 725
            .....::|.:||:..::|:..:|.......:.|.||:||:||.:.||.||.||. .|...|.|..
Mouse   527 ATIPGYMVFLRCMKSEEKSLGIGLQAFFMRLFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRT 591

  Fly   726 YDPLSM-RYTLNFTAAV--FIAIGAIFDLGVWYYAKDLKI-FDEDVKEVEMKIVQHEEEANNEKN 786
            |:..|. |..|...||:  .|.:.:.|.|.:   .:.|:| .|.|..|:|:     .|....||.
Mouse   592 YEVSSFRRLYLGLPAALRGSIILPSFFILRL---IRKLQIPGDTDSSEIEL-----AETKPTEKE 648

  Fly   787 TE 788
            :|
Mouse   649 SE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	174/654 (27%)
		MFS	114..>518	CDD:119392	112/419 (27%)
		KAZAL_SLC21	537..590	CDD:238650	23/69 (33%)
Slco1a6	NP_001368859.1	oat	1..625	CDD:273279	182/685 (27%)
Slco1a6	NP_001368859.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..670		7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820