Protein Alignment Oatp58Dc and SLCO3A1

DIOPT Version :10

• Sequence 1: NP_611659.2
• Gene: Oatp58Dc / 37545
• FlyBaseID: FBgn0034716
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_037404.2
• Gene: SLCO3A1 / 28232
• HGNCID: 10952
• Length: 710
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 196/763 - (25%)
• Similarity: 320/763 - (41%)
• Gaps: 146/763 - (19%)

  Fly    48 GNQDGEETTPKTGKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTC--GFWIFKGTFYQRFANQ 110
            |.:.||....:..::||||:|                       |:|  ...||       ..::
Human    12 GGRSGELQGDEAQRNKKKKKK-----------------------VSCFSNIKIF-------LVSE 46

  Fly   111 TAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGH 175
            .|.:|..|.||       ||....:||:|:||.:.|.:.|:|:...:|....:...::|:..:||
Human    47 CALMLAQGTVG-------AYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGH 104

  Fly   176 RPRWIGFGLLTIVFFCILTTAPHFL-----YGPGEDALALTSEFGGMPDENATMEAIEEQRSKTL 235
            |||.||.|.:.:....:|:..|.||     |..||      ..:|.              ..:.:
Human   105 RPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGE------IRWGA--------------EGRDV 149

  Fly   236 CRLNGGGAE--------CEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPAL 292
            |..||.|.:        |..........|||..||.:.|||.:....|||||:||:.::..:...
Human   150 CAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLY 214

  Fly   293 LSLSYFLRMLGPAIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSG 353
            :.:.:.:.:.|||.|:.|.|||.::|:    ....:..|...||||:||||.|:|:.|.||.||.
Human   215 IGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSS 279

  Fly   354 VFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKER-------LTAELDQKTTAEAKASFQD 411
            :.:..||:.||       .......|.|:..:...|.||       |...|:..::|......:.
Human   280 LLMFGFPQSLP-------PHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRV 337

  Fly   412 MLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVG 476
            :.|..:.|::|..:.|..|::...:.....:..|..||:|.|:..:.::::.:.|..|:..:.:|
Human   338 IPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLG 402

  Fly   477 VLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGC-PGNESSVIVNIHDSSLAGNT--- 537
            :.|.|.::.:....|.......::|..::.|..:::.|:|| .|..:.|.|...:|:..|:.
Human   403 IFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDP 467

  Fly   538 -TTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQF 601
             :.||:.|.|....::||||.:.:||:|||.|||..  .|..|      |:|:.:..|.|:|
Human   468 YSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNS--TNLTG------CACLTTVPAENAT--- 521

  Fly   602 KRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP-VNCWTQFVAFLAVMCCLKFVGASGRAS 665
                                          .:||.|| ..|...|:.||.|||....:||..:..
Human   522 ------------------------------VVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTP 556

  Fly   666 NFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLS 730
            :.::.:|.|..:.|:.|:|....|..:|.|||.|:.||...|..||.|...|..:|.|.|||.:.
Human   557 SVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVV 621

  Fly   731 MRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQHE 778
            .||.....|....:...|.....|...:         |..:..|..||
Human   622 YRYLYVSIAIALKSFAFILYTTTWQCLR---------KNYKRYIKNHE 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_611659.2	OATP	113..731	CDD:460821	174/647 (27%)
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		3/12 (25%)
		MFS_SLCO3_OATP3	39..563	CDD:340960	154/605 (25%)