DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco5a1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_766429.2	Gene:	Slco5a1 / 240726	MGIID:	2443431	Length:	850	Species:	Mus musculus

Alignment Length:	834	Identity:	227/834 - (27%)
Similarity:	366/834 - (43%)	Gaps:	150/834 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QSENPSSLGAELQDLEHGRRESRDESDVESRLLNNGKSYDKEKEAGNQDG------------EET 55
            |.|.|||:||..:..|.....|:      |..:.:..|..:...|||.||            :||
Mouse    13 QLEAPSSVGAVQEKCESESFRSK------SLPVLHSASCRQNFSAGNADGKLALGCNEAPGRQET 71

  Fly    56 ------------TPKTGKSKKKKQ---KSEQDRLMTAEINKLLAESPLEKNVTCGFWIFKGTFYQ 105
                        .|.|......:.   ....|...|..::..||                 |..:
Mouse    72 HLGRNLIVPSPSAPSTSAGTTTELMDCNHRMDPSKTVSVSSTLA-----------------TLQE 119

  Fly   106 RFANQTAYVLL-----YGIVGCIFS-----MTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQ 160
            |   :..||:|     :.:..|..:     |...|.:..|||||:|:.:.|..:|::....||..
Mouse   120 R---RCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGN 181

  Fly   161 TLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPG--EDALALTSEFGGMPDENAT 223
            .:|...::|:.|:|.||.|:..|.|.|.....|...|||:..|.  ::..|..|..|...:.|:|
Mouse   182 LVVVVFVSYFGGRGRRPLWLAVGGLLIAIGAALFALPHFISPPYQIQELNASASNDGLCQNGNST 246

  Fly   224 MEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQLLLFV-AQFISGIGGSLYYTLGVSYMDDNTKKS 287
              ||.|...   |..:.||....:       .:.||| ||.:.|:|.:..||||.:|:|||.||.
Mouse   247 --AILEPPP---CPKDSGGNSHWI-------YVALFVCAQVLIGMGSTPIYTLGPTYLDDNVKKD 299

  Fly   288 KTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPV-INNKDPRWLGAWWLGWLVMGGLLSF 351
            .....|::.|.:..||||:||.|....:..|:.|: :|| ::..|||::|.||.|:|:. .:..|
Mouse   300 NASLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPR-NPVHLDQSDPRFIGNWWSGFLLC-AIAMF 362

  Fly   352 SGVF-LSMFPKELPRAVARRKVEENRRREKERLSVKST-------EKERLTAELDQKTTAEA-KA 407
            ..:| :..|||:||          .|.::|::.|....       ||...:.::::|.:... ..
Mouse   363 LVIFPMFTFPKKLP----------PRHKKKKKFSADVVIDDDIIKEKSNTSEQMNKKVSPMGFGK 417

  Fly   408 SFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAF 472
            :.:|:.:...|:::|.|::..:||........|.:..|.||:||.|:...|:.:|:.||.:.:..
Mouse   418 NVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPS 482

  Fly   473 SAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGNT 537
            :.||::|.|:||.:.|..||..|...:|...:::........:||   ||..:..|:.....|.:
Mouse   483 AGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGC---ESINLGGINIPYTTGPS 544

  Fly   538 TT---------CNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNS----EGKKIFYDCSCI 589
            .|         ||..|.|....|.||||.:.:||.:.|.|||    :||    .|.:.:.:|:|:
Mouse   545 LTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGC----INSGNLTTGVRNYTECTCV 605

  Fly   590 PSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEAL-------ANGQAMPGACPVNCWTQFVA 647
            .|...              ::...|.|    .|||..:       .||.|:.|.|...|.| .:.
Mouse   606 QSRQV--------------ITPPTVGQ----RSQLRVVIVKTYLNENGYAVSGKCKRTCNT-LIP 651

  Fly   648 FLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLV 712
            ||..:..:.|:.|..:.|..:|::|.|.::::..|:|....|...||:||:||:||.|.|..|::
Mouse   652 FLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCML 716

  Fly   713 WGKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDED 766
            |.:.|..:|:||.|:..|.|:.....||....:|.||....||..|    :.||
Mouse   717 WQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIK----YKED 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	189/661 (29%)
		MFS	114..>518	CDD:119392	121/426 (28%)
		KAZAL_SLC21	537..590	CDD:238650	21/65 (32%)
Slco5a1	NP_766429.2	MFS_SLCO5_OATP5	131..676	CDD:340962	164/594 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810