DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Dc and F47E1.2

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_509531.1	Gene:	F47E1.2 / 181145	WormBaseID:	WBGene00018566	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	814	Identity:	190/814 - (23%)
Similarity:	315/814 - (38%)	Gaps:	205/814 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 WIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQT 161
            :||.|.|        ::|.....:|      .:|.|..:..||::|::.|:.:|.:...:|....
Worm     5 YIFLGLF--------SFVFFLEAIG------GSYINSAVQNIERQFQMSSRTSGFMISASDFGYI 55

  Fly   162 LVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGE------DALALTSEFGGMPDE 220
            .....:|::..||:|.||||.|.:.:....::..:|:||:..|.      :..|......|....
Worm    56 PCVVFIAHFGSKGNRARWIGAGAILVSITYLMLASPNFLFPQGHHDINTTEVSAKLKPTAGQLAS 120

  Fly   221 NATME----------------------------AIEEQ--------------------------- 230
            |:|::                            .|||.
Worm   121 NSTLKQLLSYQLIRDRMPHDTYMSLINLEDDTTPIEEYQPIGRPPKIGQGQSGNSTYTIDGWLFN 185

  Fly   231 -------------------RSK---------------------------TLC-RLNGG------G 242
                               ||.                           |.| :|...      .
Worm   186 EALVAAENLIANNTSQNTLRSSLSLFIHRRTNTSTKDIQKIRISAAAPFTFCGKLTNSLRAVIKD 250

  Fly   243 AECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIG 307
            ::|:....|..|.|:.|.:..:.|||.::.::|||..:|||.||...||.......:|:|||..|
Worm   251 SKCKEQTSNSYPFLVFFFSLLLLGIGRTVPWSLGVPLLDDNIKKKSLPAYFGAISSIRVLGPICG 315

  Fly   308 YALASFCLRLYIAPQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAVARRKV 372
            |.:.|||.:.|........:...||.|:||||:|:|.:|.:..|....|..||
Worm   316 YMIGSFCNKFYYTLNPPNGLTPADPTWIGAWWMGFLFIGSIALFPSTMLFFFP------------ 368

  Fly   373 EENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLV 437
             :.:..:...:.::...||:|...:|:..|...|  .:|..|:.:::::.|.||.:.|..:..::
Worm   369 -QGKEGDGSAVQLRDVHKEKLKKSVDEDRTITMK--LKDFAKSCKKVLSTKIYMGSVLGRVCDVL 430

  Fly   438 GYTPYWIFTPKYIEVQYRQSAATSSMVTGTVAL--AFS-AVGVLLSGFIISRYKPRARYMAAWNV 499
            .:..|.:|.|||:|..:   .....:|...:|:  .|. .:||...|::..:.|...|..|.:.:
Worm   431 AFKGYIVFLPKYLENHF---GIPQYLVHRYMAMFGVFGFGLGVATGGYVTKKLKLNGRRAAMFVM 492

  Fly   500 IVGFLTVAGILAYAFIGCPGNESSVIVNIHDSSLAGN---TTTCNSACSCDYVRYSPVCGENNMT 561
            ::..|.|.......||||    .|::.:|..::...|   |..|||.|||:..|..|||.:....
Worm   493 LMSTLNVCLYSGKIFIGC----ESIVNSIGSNNRQTNYNFTRECNSQCSCENARLYPVCDQTGFA 553

  Fly   562 YISACHAGCKKLL-VNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLE 625
            |.|.|||||::.: ..|:....|..|.|.|   .|..:.:|
Worm   554 YFSPCHAGCREAMQYGSDPVLDFTSCQCAP---GGVVSKKF------------------------ 591

  Fly   626 ALANGQAMPGACPVNCWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLC 690
                       |...|.|..|.|...:....||...|.....|:.:|.||.:.::.::|......
Worm   592 -----------CENTCKTSSVIFFLTVLPGSFVAGLGVVPAMLILLRSVPPETRSLSLGLQGMAV 645

  Fly   691 SMLAFIPSPIFFGWVFDRVCLVWGKTCTN-KGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVW 754
            |:...:||||.:|.|.|..||||.|.|.. :|:|.:|.|..:|..::....|...:..|.|:.||
Worm   646 SLFGTLPSPILWGLVIDAACLVWDKACNGARGSCSIYHPDRLRVWMHLLYVVIRTVALITDVYVW 710

  Fly   755 YYAKDLKIFDEDVKE---------VEMKIVQHEE 779
            .:||:|.|.||.|.|         ::|:.||.::
Worm   711 KHAKNLNIMDEPVSEEKDNIRRNSIKMQAVQPDQ 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	169/740 (23%)
		MFS	114..>518	CDD:119392	109/520 (21%)
		KAZAL_SLC21	537..590	CDD:238650	22/53 (42%)
F47E1.2	NP_509531.1	MFS	8..>92	CDD:119392	21/97 (22%)
		oat	95..715	CDD:273279	154/679 (23%)
		MFS	<274..>503	CDD:304372	66/246 (27%)
		KAZAL_SLC21	528..583	CDD:238650	22/54 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6305
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	1	0.900	-	-		OOG6_108756
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.600