DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Dc and K02G10.5

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001294796.1	Gene:	K02G10.5 / 180742	WormBaseID:	WBGene00019346	Length:	642	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	190/706 - (26%)
Similarity:	294/706 - (41%)	Gaps:	135/706 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNG----TITTIEKRFKIP 145
            |:|.      ||..|:....|..:|   ::....|:.....:..|..||    :|::||||||:.
Worm     6 ETPF------GFSWFRPKGLQWLSN---FIPFMSILSANAMLQGAIVNGLVSVSISSIEKRFKLT 61

  Fly   146 SKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGP---GEDA 207
            |..:||.:...|:..|::...||.||.|.::.:.||.|::.:....||...|.:..||   ||
Worm    62 STQSGIFAATYDVFVTVMLIPLALYATKVNKVKCIGLGMMIVGIGSILVIIPEYTAGPYSVGE-- 124

  Fly   208 LALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGN-FAPQ---LLLFVAQFISGIG 268
                                   ..|.:|...|....|..|..: |:..   |||.::|...|||
Worm   125 -----------------------VKKDVCVTGGPDKVCSEGSSDTFSAHRELLLLLLSQAFVGIG 166

  Fly   269 GSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLY----IAPQMHPVINN 329
            .|..:|.|::.:|:.....:|...|:|......:|||:.:....|.|||:    .:|....:.|:
Worm   167 ASPLFTYGITCLDEFDSHKRTGRNLALYMIASTVGPALAFVGCGFMLRLWGDWRTSPAEMGIDNS 231

  Fly   330 KDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKERLT 394
            .|||::|.||:|::|.|.:..|:...|.||||.|.....|                |:.:..|..
Worm   232 ADPRFIGMWWIGFVVCGFVALFTAFPLIMFPKRLKDTTVR----------------KANDVHRTD 280

  Fly   395 AELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAA 459
            |.|| |..::.|..|   .|....|..|||.||..|......:....|..|.||.:|.....|:.
Worm   281 ASLD-KDFSDHKYEF---FKIIFMLFKNKTCMCVILMQTIEAMLMNGYITFIPKLLETLLGFSSG 341

  Fly   460 TSSMVTG----TVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGCPGN 520
            .:|::||    .|.:..|.:|..:|....:|:||     :.:.|||..:..||..:...|.|
Worm   342 NASLITGGVVVPVGIVASYIGGRISKLFENRFKP-----SMYFVIVFGIMAAGCSSCLLIRC--- 398

  Fly   521 ESSVI--VNIHDSSLA--GNTTTCNSACSCDYVRYSPVCGENN-MTYISACHAGCKKLLVNSEGK 580
            ||..:  ||:..|.|.  |...||:..|.||.. ::|||.|:: :|::|.|||||..:.....|.
Worm   399 ESLNVYGVNVPSSDLPRYGALETCSENCHCDSF-FNPVCSEDSKLTFLSPCHAGCADMPGIKFGA 462

  Fly   581 KIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQ- 644
            ..:.:|.|                          |:||.|..            |.|..:|..|
Worm   463 SNWTNCGC--------------------------SKNTIVKK------------GYCDASCQKQI 489

  Fly   645 ---FVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVF 706
               .:.|:|:..|: |:.|....|:   |:|.|..|.:.....||.....:|..||..|.||::.
Worm   490 YQFIIMFIALSFCI-FITAPVLQSS---SLRVVNHKHRDHFTCFGWLWMRILGSIPGAIVFGYII 550

  Fly   707 DRVCLVWGKTCTNKGNCWLYDPLSMRYT-LNFTAAVFIAIGAIFDLGVWYYAKDLK 761
            |..|:.|.|.|.:: .|..|:..::.:. ..||.||....|.:..|..:.|.:..|
Worm   551 DVNCMYWQKDCVSQ-KCQFYNASNLGWAFFYFTIAVKFTGGILLFLAAYCYQESDK 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	175/646 (27%)
		MFS	114..>518	CDD:119392	115/422 (27%)
		KAZAL_SLC21	537..590	CDD:238650	19/53 (36%)
K02G10.5	NP_001294796.1	oat	1..602	CDD:273279	189/701 (27%)
		MFS	36..>390	CDD:119392	112/403 (28%)
		KAZAL_SLC21	421..470	CDD:238650	18/49 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810