DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco4a1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_598292.2	Gene:	Slco4a1 / 171144	RGDID:	620228	Length:	723	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	190/770 - (24%)
Similarity:	324/770 - (42%)	Gaps:	149/770 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GEETTPKTGKSKKKKQK------SEQDRLMTAEINKLLAESPLE--------KNVTCGFWIFKGT 102
            |.:|.|.:..|....:.      |....|...::.|..:::..|        ::..||:..|...
  Rat    29 GCDTPPSSRASPASLRSAHGALGSSSQPLFEPQVEKRSSQAAREVQYLSSGPQSTLCGWQSFTPK 93

  Fly   103 FYQRFANQTAYVLLYGIVGCIFSMTY-AYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAV 166
            ..|.|.....::........:..||. .:.|..||:||:||.:.|..:|:|:...||:..|....
  Rat    94 CLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTF 158

  Fly   167 LAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQR 231
            ::|:.|.||:|||:|:|.|.:....::...|||..|..|  :.:..|  |:..|..|
  Rat   159 VSYFGGNGHKPRWLGWGALVLGIGSLVFALPHFTAGRYE--VEIDDE--GLGTETGT-------- 211

  Fly   232 SKTLCRLNGGGAEC-EVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSL 295
                |..|....|| :...|..:.:|:..:.|.:.|:|.:..|||||:|:|:|.|.|.:|..:::
  Rat   212 ----CLTNQSQVECKDRASGLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAI 272

  Fly   296 SYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFP 360
            .|...:||||.||.:....|.:|........:....|.|:||||:|:|..|.......:.:..:|
  Rat   273 FYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYP 337

  Fly   361 KELP---RAVARRKVEENRRREKERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITN 422
            ::||   |.|..|..|..:.::..|                 ...|..| :.:|:..:...|:.|
  Rat   338 RQLPGSQRYVVMRAAETQQLKDHSR-----------------DNPAFGK-TVRDLPLSVWILLRN 384

  Fly   423 KTYMCNTLSSIFYLVGYTPYWI------FTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSG 481
            .|::      :..|.|.|...:      |.||:.|.|:..||:.::.:.|.:.:.....|.||.|
  Rat   385 PTFI------LLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGG 443

  Fly   482 FIISRYKPRARYMAAWNVIVGFLTVAGILAY--AFIGCPGNESSVIVNIHDSSLAGNTT------ 538
            |:::::|.|...:..:.:   |.|:..:||:  ..:.||        |:|   :||.||
  Rat   444 FLVNKFKLRGSGIIRFCL---FCTLTSLLAFFVFLMHCP--------NVH---MAGVTTGYVGSL 494

  Fly   539 ----------TCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSE-GKKIFYDCSCIPSD 592
                      .||:...|....|||:||.:...|.|.|:|||.:..|... |:|::..||||
  Rat   495 LPKGQLDLKAACNALYCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRGCSCI--- 556

  Fly   593 DAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALAN--GQAMPGACPVNCWTQFVAFLAVMCCL 655
                                           ||..::  |.|..|.|...|.::.:..:.|...:
  Rat   557 -------------------------------LEKASSGWGNATAGKCASTCQSKPLLLVLVFVVI 590

  Fly   656 KFVGASGRASNFLVSV-------RCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVW 713
            .|        .||.|:       |||.::.::.|:|....:...|..||.||.||||.|:.||:|
  Rat   591 IF--------TFLSSIPALTATLRCVCDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLW 647

  Fly   714 GKTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVK 768
            ...|.::|:|::|...:|...|......|..:|.:|.:..::..|...:..:.::
  Rat   648 QDQCGHQGSCFVYKNEAMSRYLLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLE 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	171/657 (26%)
		MFS	114..>518	CDD:119392	108/416 (26%)
		KAZAL_SLC21	537..590	CDD:238650	22/69 (32%)
Slco4a1	NP_598292.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..57		5/27 (19%)
		OATP	103..665	CDD:281175	171/657 (26%)
		MFS	105..>340	CDD:119392	73/250 (29%)
		KAZAL_SLC21	502..556	CDD:238650	19/53 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910