DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco6b1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_596903.1	Gene:	Slco6b1 / 170925	RGDID:	620278	Length:	748	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	162/708 - (22%)
Similarity:	278/708 - (39%)	Gaps:	144/708 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 QRFANQTAYVLLYGIV----GCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSA 165
            |||.|...:::.:.|:    |.:|.:|    :.:|...|:.|.:......:::...|:|..||..
  Rat   137 QRFNNINFFLISFCILTLAQGIVFGLT----DLSIGNFERDFYLSHPEKILLTTAYDLSSLLVVI 197

  Fly   166 VLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQ 230
            ::|:|.|:|.|.||:......:....|:...|:..|    :.:....|.|.:..:       |||
  Rat   198 IVAHYGGRGRRSRWVATAAFLVGLGSIIGALPYLKY----EVIHPVEETGELCKD-------EEQ 251

  Fly   231 RSKTLCRLNGGGAECEVGEGNFAPQLLLF---------VAQFISGIGGSLYYTLGVSYMDDNTKK 286
            |:...|.                 :::.|         :.|...|......|.||::|:.||...
  Rat   252 RTMPNCE-----------------KIIPFKSEIIYLSVIGQCFQGFASMPMYVLGMTYIYDNISS 299

  Fly   287 SKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPR--------WLGAWWLGWL 343
            ......|.::....:||..:|||:.|        |.:.|.:|:....        |...|:||:.
  Rat   300 YLAGIYLGIADASFVLGYGLGYAVGS--------PNLRPSLNHSSEEKVNDNFLWWQFNWFLGFF 356

  Fly   344 VMGGLLSFSGVF-LSMFPKELPRAVARRKVEENR----RREKERLSVKSTEKERLTAELDQKTTA 403
             ...||::..|| |..||..||.:...|..:||.    ::.|:                     .
  Rat   357 -SATLLAWFTVFPLLCFPHRLPGSNKLRVWKENEPFFYKKYKD---------------------L 399

  Fly   404 EAKASFQDMLKTFRRLITNKTYMCNTL---SSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVT 465
            :...||||:|:....|:.|...||.::   :....|:|.|.   |.|||:|.|:..|.::::::|
  Rat   400 KYGYSFQDLLRALWYLVKNPLLMCYSMCKATESLALIGATE---FLPKYLENQFLLSPSSAALLT 461

  Fly   466 GTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAY------AFIGCPGNESSV 524
            |.:.:...|:|..|.|||:|:.|...:..      :.|:||..:::.      ||:.|...:.:.
  Rat   462 GIILIPGGAIGNFLGGFIVSKMKMSCKTQ------MRFITVTSVISLLLFVLNAFVKCERVKFAG 520

  Fly   525 IVNIHDSS--LAGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEG---KKIFY 584
            |.:.::.|  |...|..||:.|.|....|..:||.:.:.|.|.|.|||    :||:.   :|..|
  Rat   521 INSDYEGSGTLGNLTAPCNAHCGCTSHTYYAICGRDEIEYFSPCFAGC----LNSKELNYEKTLY 581

  Fly   585 DCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVNCWTQFVAFL 649
            :||||...           |.:.|..||.:                .|..|.|...|:...:.|.
  Rat   582 NCSCIKHG-----------LANADSENDPI----------------DAFLGKCNTKCYALPLFFA 619

  Fly   650 AVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWG 714
            .....:.| .:|......|:.:|.:|....:..:....|:..:...||.|:.|.......|..|.
  Rat   620 FFFSSIVF-SSSASIPITLIILRTLPTSLHSLGLAVTYTILRIFGSIPGPLLFRIASSSSCSYWD 683

  Fly   715 -KTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVE 771
             ..|..:|:||:|:...|...|.........|..:..|........|::..|.||:.:
  Rat   684 INKCGLRGHCWIYNKFKMMSILMGLCISCKLISTLLSLLALLKYNVLRVGSEGVKKTK 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	150/659 (23%)
		MFS	114..>518	CDD:119392	98/438 (22%)
		KAZAL_SLC21	537..590	CDD:238650	21/55 (38%)
Slco6b1	NP_596903.1	OATP	144..701	CDD:281175	150/659 (23%)
		MFS	146..>510	CDD:119392	96/434 (22%)
		KAZAL_SLC21	534..587	CDD:238650	21/56 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810