DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco3a1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_803434.1	Gene:	Slco3a1 / 140915	RGDID:	620227	Length:	710	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	194/765 - (25%)
Similarity:	319/765 - (41%)	Gaps:	150/765 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GNQDGEETTPKTGKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTC--GFWIFKGTFYQRFANQ 110
            |.:.||....:..::||||:|                       |:|  ...||       ..::
  Rat    12 GGRSGELQGDEAQRNKKKKKK-----------------------VSCFSNIKIF-------LVSE 46

  Fly   111 TAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGH 175
            .|.:|..|.||       ||....:||:|:||.:.|.:.|:|:...:|....:...::|:..:||
  Rat    47 CALMLAQGTVG-------AYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGH 104

  Fly   176 RPRWIGFGLLTIVFFCILTTAPHFL-----YGPGEDALALTSEFGGMPDENATMEAIEEQRSKTL 235
            |||.||.|.:.:....:|:..|.||     |..||      ..:|.              ..:.:
  Rat   105 RPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGE------IRWGA--------------EGRDV 149

  Fly   236 CRLNGGGAE--------CEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPAL 292
            |..||..::        |..........|||..||.:.|||.:....|||||:||:.::..:...
  Rat   150 CATNGSSSDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLY 214

  Fly   293 LSLSYFLRMLGPAIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSG 353
            :.:.:.:.:.|||.|:.|.|||.::|:    ....:..|...||||:||||.|:|:.|.||.||.
  Rat   215 IGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSS 279

  Fly   354 VFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKER-------LTAELDQKTTAEAKASFQD 411
            :.:..||:.||       .......|.|:..:...|.||       |...|:..::|......:.
  Rat   280 LLMFGFPQSLP-------PHSEPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRV 337

  Fly   412 MLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVG 476
            :.|..:.|::|..:.|..|::...:.....:..|..||:|.|:..:.::::.:.|..|:..:.:|
  Rat   338 IPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLG 402

  Fly   477 VLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGC---PGNESSVIVNIHDSSLAGNT- 537
            :.|.|.::.:....|.......::|..::.|..:::.|:||   |  .:.|.|...::|..|:.
  Rat   403 IFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTVP--VAGVTVRYGNNSARGSPL 465

  Fly   538 ---TTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTS 599
               :.||:.|.|....::||||.:.:||:|||.|||..  .|..|      |:|:.:....|:|
  Rat   466 DPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNS--TNLTG------CACLTTVPPENAT- 521

  Fly   600 QFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP-VNCWTQFVAFLAVMCCLKFVGASGR 663
                                            .:||.|| ..|...|:.||.|||....:||..:
  Rat   522 --------------------------------VVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQ 554

  Fly   664 ASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDP 728
            ..:.::.:|.|..:.|:.|:|....|..:|.|||.|:.||...|..||.|...|..:|.|.|||.
  Rat   555 TPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDN 619

  Fly   729 LSMRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQHE 778
            :..||.....|....:...|.....|...:         |..:..|..||
  Rat   620 VVYRYLYVSIAIALKSFAFILYTTTWQCLR---------KNYKRYIKNHE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	173/650 (27%)
		MFS	114..>518	CDD:119392	109/430 (25%)
		KAZAL_SLC21	537..590	CDD:238650	20/56 (36%)
Slco3a1	NP_803434.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		3/12 (25%)
		OATP	41..619	CDD:281175	174/661 (26%)
		MFS	47..>286	CDD:119392	77/265 (29%)
		KAZAL_SLC21	467..511	CDD:238650	19/51 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750