DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and SLCO6A1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001275931.1	Gene:	SLCO6A1 / 133482	HGNCID:	23613	Length:	719	Species:	Homo sapiens

Alignment Length:	712	Identity:	167/712 - (23%)
Similarity:	289/712 - (40%)	Gaps:	122/712 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIF 124
            |..|:||.||...: ...|::..| |.|      ||......|..:...|...:::.|.|:....
Human    63 GFRKRKKAKSSVSK-KPGEVDDSL-EQP------CGLGCLVSTCCECCNNIRCFMIFYCILLICQ 119

  Fly   125 SMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVF 189
            .:.:...:.:|...:|.:::.:.....:....|||..||:..:|:|   |.|.:.|.|
Human   120 GVVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIAFY---GDRKKVIWF------- 174

  Fly   190 FCILTTAPHFLYGPGEDALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAP 254
                 .|..||.|.|    :|...|..:.:||...:...|...:.:..::|    |:....:|..
Human   175 -----VASSFLIGLG----SLLCAFPSINEENKQSKVGIEDICEEIKVVSG----CQSSGISFQS 226

  Fly   255 QLLLF--VAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRL 317
            :.|.|  :.|.:.||.|...|.||::::|:|.........|.::....|:|.|:||.|.:..:::
Human   227 KYLSFFILGQTVQGIAGMPLYILGITFIDENVATHSAGIYLGIAECTSMIGYALGYVLGAPLVKV 291

  Fly   318 YIAPQ-----MHPVINNKDPRWLGAWWLGWLVMGGLLSFSGVFLSMFPKELPRAVARRKVEENRR 377
               |:     .:..:||..|.||..||:.:|....:...:.:.||.||..:|.:.   :::..:|
Human   292 ---PENTTSATNTTVNNGSPEWLWTWWINFLFAAVVAWCTLIPLSCFPNNMPGST---RIKARKR 350

  Fly   378 RE----KERLSVKSTEKERLTAELDQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVG 438
            ::    ..||.             |.|.....|    |:......|:.|...:|..||..
Human   351 KQLHFFDSRLK-------------DLKLGTNIK----DLCAALWILMKNPVLICLALSKA----- 393

  Fly   439 YTPYWI------FTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAW 497
             |.|.:      |.|.|:|.|:..:...::.:.|.|.:...|:|.||.|.|:|..:...:.:..:
Human   394 -TEYLVIIGASEFLPIYLENQFILTPTVATTLAGLVLIPGGALGQLLGGVIVSTLEMSCKALMRF 457

  Fly   498 NVIVGFLTVAGILAYAFIGCPGNESSVIVNIHDSS--LAGNTTTCNSACSCDYVRYSPVCGENNM 560
            .::...:::..::...|:.|...:.:.|...:|.:  |...|..||..|.|....||.:||.:::
Human   458 IMVTSVISLILLVFIIFVRCNPVQFAGINEDYDGTGKLGNLTAPCNEKCRCSSSIYSSICGRDDI 522

  Fly   561 TYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLE 625
            .|.|.|.|||......:: ||::|:||||.           :.|.:.|...|.:
Human   523 EYFSPCFAGCTYSKAQNQ-KKMYYNCSCIK-----------EGLITADAEGDFI----------- 564

  Fly   626 ALANGQAMPGACPVNCW--TQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGMT 688
                 .|.||.|...|:  ..|:||  :...|.|.|.|| ....|...|.||:|.::.|:|....
Human   565 -----DARPGKCDAKCYKLPLFIAF--IFSTLIFSGFSG-VPIVLAMTRVVPDKLRSLALGVSYV 621

  Fly   689 LCSMLAFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIF 749
            :..:...||.|..|....:..|::.. ..|.:.|.||:|         |.|...|:.:|..|
Human   622 ILRIFGTIPGPSIFKMSGETSCILRDVNKCGHTGRCWIY---------NKTKMAFLLVGICF 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	148/640 (23%)
		MFS	114..>518	CDD:119392	89/420 (21%)
		KAZAL_SLC21	537..590	CDD:238650	21/52 (40%)
SLCO6A1	NP_001275931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		OATP	107..665	CDD:281175	150/649 (23%)
		MFS	109..>330	CDD:119392	55/246 (22%)
		KAZAL_SLC21	498..551	CDD:238650	21/53 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810