DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Dc and Slco3a1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_076397.2	Gene:	Slco3a1 / 108116	MGIID:	1351867	Length:	710	Species:	Mus musculus

Alignment Length:	763	Identity:	195/763 - (25%)
Similarity:	321/763 - (42%)	Gaps:	146/763 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GNQDGEETTPKTGKSKKKKQKSEQDRLMTAEINKLLAESPLEKNVTC--GFWIFKGTFYQRFANQ 110
            |.:.||....:..::||||:|                       |:|  ...||       ..::
Mouse    12 GGRSGELQGDEAQRNKKKKKK-----------------------VSCFSNIKIF-------LVSE 46

  Fly   111 TAYVLLYGIVGCIFSMTYAYFNGTITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGH 175
            .|.:|..|.||       ||....:||:|:||.:.|.:.|:|:...:|....:...::|:..:||
Mouse    47 CALMLAQGTVG-------AYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGH 104

  Fly   176 RPRWIGFGLLTIVFFCILTTAPHFL-----YGPGEDALALTSEFGGMPDENATMEAIEEQRSKTL 235
            |||.||.|.:.:....:|:..|.||     |..||      ..:|.              ..:.:
Mouse   105 RPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGE------IRWGA--------------EGRDV 149

  Fly   236 CRLNGGGAE--------CEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPAL 292
            |..||..::        |..........|||..||.:.|||.:....|||||:||:.::..:...
Mouse   150 CATNGSSSDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLY 214

  Fly   293 LSLSYFLRMLGPAIGYALASFCLRLYI----APQMHPVINNKDPRWLGAWWLGWLVMGGLLSFSG 353
            :.:.:.:.:.|||.|:.|.|||.::|:    ....:..|...||||:||||.|:|:.|.||.||.
Mouse   215 IGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSS 279

  Fly   354 VFLSMFPKELPRAVARRKVEENRRREKERLSVKSTEKER-------LTAELDQKTTAEAKASFQD 411
            :.:..||:.||       ...:...|.|:..:...|.||       |...|:..::|......:.
Mouse   280 LLMFGFPQSLP-------PHSDPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRV 337

  Fly   412 MLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVG 476
            :.|..:.|::|..:.|..|::...:.....:..|..||:|.|:..:.::::.:.|..|:..:.:|
Mouse   338 IPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLG 402

  Fly   477 VLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAFIGC-PGNESSVIVNIHDSSLAGNT--- 537
            :.|.|.::.:....|.......::|..::.|..:::.|:|| .|..:.|.|...::|..|:.
Mouse   403 IFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVRYGNNSARGSALDP 467

  Fly   538 -TTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKKIFYDCSCIPSDDAGNSTSQF 601
             :.||:.|.|....::||||.:.:||:|||.|||..  .|..|      |:|:
Mouse   468 YSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNS--TNLTG------CACL------------ 512

  Fly   602 KRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACP-VNCWTQFVAFLAVMCCLKFVGASGRAS 665
                            |:|..:     |...:||.|| ..|...|:.||.|||....:||..:..
Mouse   513 ----------------TTVPPE-----NASVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTP 556

  Fly   666 NFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLS 730
            :.::.:|.|..:.|:.|:|....|..:|.|||.|:.||...|..||.|...|..:|.|.|||.:.
Mouse   557 SVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVV 621

  Fly   731 MRYTLNFTAAVFIAIGAIFDLGVWYYAKDLKIFDEDVKEVEMKIVQHE 778
            .||.....|....:...|.....|...:         |..:..|..||
Mouse   622 YRYLYVSIAIALKSFAFILYTTTWQCLR---------KNYKRYIKNHE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	174/648 (27%)
		MFS	114..>518	CDD:119392	109/428 (25%)
		KAZAL_SLC21	537..590	CDD:238650	20/56 (36%)
Slco3a1	NP_076397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		3/12 (25%)
Slco3a1	NP_076397.2	MFS_SLCO3_OATP3	39..563	CDD:340960	153/605 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750