DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and Slco4a1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001342147.1	Gene:	Slco4a1 / 108115	MGIID:	1351866	Length:	723	Species:	Mus musculus

Alignment Length:	799	Identity:	197/799 - (24%)
Similarity:	338/799 - (42%)	Gaps:	165/799 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ESRLLNNGKSYDKEKEAGNQDGEETTPKT--------------GKSKKK--KQKSEQDRLMTAEI 79
            ::..|:..|.......:....|.:|.|.:              |.|.:.  :.::|:....||..
Mouse     8 DTHFLSLPKHLFTSTSSATDSGCDTPPSSRASPASLRSAHGTLGSSSQPLFEPQAEKRSSQTARE 72

  Fly    80 NKLLAESPLEKNVTCGFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTY-AYFNGTITTIEKRFK 143
            .:.::..|  :|..||:..|.....|.|.....::........:..||. .:.|..||:||:||.
Mouse    73 VQYVSSGP--QNSLCGWQAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFD 135

  Fly   144 IPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGEDAL 208
            :.|..:|:|:...||:..|....::|:.|.||:|||:|:|:|.:....::...|||..|..|
Mouse   136 LHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAGRYE--- 197

  Fly   209 ALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECE---VGEGNFAPQLLLFVAQFISGIGGS 270
                            ..::|......|..|....||:   .|..|:  :|:..:.|.:.|:|.:
Mouse   198 ----------------VEMDEGLGTGTCLTNQSHVECKDSASGLSNY--RLIFMLGQLLHGVGAT 244

  Fly   271 LYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYIAPQMHPVINNKDPRWL 335
            ..|||||:|:|:|.|.|.:|..:::.|...:||||.||.:....|.:|........:....|.|:
Mouse   245 PLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWV 309

  Fly   336 GAWWLGWLVMGGLLSFSGVFLSMFPKELP---RAVARRKVEENRRREKERLSVKSTEKERLTAEL 397
            ||||:|:|..|.......:.:..:|::||   |.|..|..|..:.::..|.:|.:
Mouse   310 GAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRGAVSN---------- 364

  Fly   398 DQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWI------FTPKYIEVQYRQ 456
                .|..| :.:|:..:...|:.|.|::      :..|.|.|...:      |.||:.|.|:..
Mouse   365 ----PAFGK-TVRDLPLSIWLLLRNPTFI------LLCLAGATEATLIAGMSTFGPKFFEAQFSL 418

  Fly   457 SAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAY--AFIGCPG 519
            ||:.::.:.|.:.:.....|.||.||:::::|.|...:..:.:   |.|:..:||:  ..:.||
Mouse   419 SASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCL---FCTLTSLLAFFVFLMHCP- 479

  Fly   520 NESSVIVNIHDSSLAGNTT----------------TCNSACSCDYVRYSPVCGENNMTYISACHA 568
                   |:|   :||.||                .||:...|....|||:||.:...|.|.|:|
Mouse   480 -------NVH---MAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYA 534

  Fly   569 GCKKLLVNSE----GKKIFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALAN 629
            ||.   .::|    |:|::..||||                                  ||..::
Mouse   535 GCP---ADAETDLGGQKVYRGCSCI----------------------------------LEKASS 562

  Fly   630 --GQAMPGACPVNCWTQFVAFLAVMCCLKFVGASGRASNFLVSV-------RCVPEKDKTAAMGF 685
              |.|..|.|...|  |...||.|:..:..:      ..||.|:       |||.::.::.|:|.
Mouse   563 GWGNATAGKCASTC--QSKPFLLVLVFVVII------FTFLSSIPALTATLRCVSDRQRSFALGI 619

  Fly   686 GMTLCSMLAFIPSPIFFGWVFDRVCLVWGKTCTNKGNCWLYDPLSM-RYTLNFTAAVFIAIGAIF 749
            ...:...|..||.||.||||.|:.||:|...|.::|:|::|:..:| ||.| .....|..:|.:|
Mouse   620 QWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRYML-IAGLTFKVLGFLF 683

  Fly   750 DLGVWYYAKDLKIFDEDVK 768
            .:..::..|...:..:.::
Mouse   684 FVAAYFLYKSPSVSSDGLE 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	172/662 (26%)
		MFS	114..>518	CDD:119392	107/418 (26%)
		KAZAL_SLC21	537..590	CDD:238650	22/72 (31%)
Slco4a1	NP_001342147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..64		5/40 (13%)
		OATP	103..665	CDD:308646	172/662 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810