DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Dc and SLCO1B1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_006437.3	Gene:	SLCO1B1 / 10599	HGNCID:	10959	Length:	691	Species:	Homo sapiens

Alignment Length:	759	Identity:	200/759 - (26%)
Similarity:	317/759 - (41%)	Gaps:	138/759 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 INKLLAESPLEKNVT--C-GFWIFKGTFYQRFANQTAYVLLYGIVGCIFSMTYAYFNGTITTIEK 140
            :||.....|.|...|  | |..:|.......|..:|        :|.|.      ...:|..||:
Human     7 LNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKT--------LGAII------MKSSIIHIER 57

  Fly   141 RFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPRWIGFGLLTIVFFCILTTAPHFLYGPGE 205
            ||:|.|...|.|....:|...||...::|:..|.|||:.||.|...:....:||..|||..|
Human    58 RFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMG--- 119

  Fly   206 DALALTSEFGGMPDENATMEAIEEQRSKTLCRLNGGGAECEVGEGNFAPQ-----LLLFVAQFIS 265
             ....:.|......||:| ..:.......:..||....|. ||:|.....     :.:|:...:.
Human   120 -YYRYSKETNINSSENST-STLSTCLINQILSLNRASPEI-VGKGCLKESGSYMWIYVFMGNMLR 181

  Fly   266 GIGGSLYYTLGVSYMDDNTKKSKTPALLSLSYFLRMLGPAIGYALASFCLRLYI---APQMHPV- 326
            |||.:....||:||:||..|:..:...|.:...:.|:||.||:.|.|...::|:   ...:..:
Human   182 GIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIR 246

  Fly   327 INNKDPRWLGAWWLGWLVMGGLLSFSGV---FLSMFPKELPRAVARRKVEENRRREKERLSVKST 388
            |...|.||:|||||.:||.|.....|.:   ||...|.:          .:..|:....|.|..|
Human   247 ITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNK----------PQKERKASLSLHVLET 301

  Fly   389 EKER-LTAEL---DQKTTAEAKASFQDMLKTFRRLITNKTYMCNTLSSIFYLVGYTPYWIFTPKY 449
            ..|: .||.|   .:..|......||    :|:.::||..|:...|.::..:..|...:.:..||
Human   302 NDEKDQTANLTNQGKNITKNVTGFFQ----SFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKY 362

  Fly   450 IEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFIISRYKPRARYMAAWNVIVGFLTVAGILAYAF 514
            :|.||.|.::.::::.|.:.:...|.|:.|.|:||.::|.....:|.::.....::::..|.|.|
Human   363 VEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFF 427

  Fly   515 IGCPGNESSVIVNIHDSSLAGNTTT-----------------CNSACSCDYVRYSPVCGENNMTY 562
            |.|           .:.|:||.|.|                 |||.|:||..::.||||.|.:||
Human   428 ILC-----------ENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITY 481

  Fly   563 ISACHAGCKKLLVNSEGKK---IFYDCSCIPSDDAGNSTSQFKRLTSFDLSNDEVSQNTSVHSQL 624
            ||.|.||||    :|.|.|   :||:|||:......|                   :|.|.|.
Human   482 ISPCLAGCK----SSSGNKKPIVFYNCSCLEVTGLQN-------------------RNYSAHL-- 521

  Fly   625 EALANGQAMPGACPVN--CWTQFVAFLAVMCCLKFVGASGRASNFLVSVRCVPEKDKTAAMGFGM 687
                      |.||.:  |..:|..|:|:.....|..|.|..|:.::.|:.|..:.|:.|:||..
Human   522 ----------GECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHS 576

  Fly   688 TLCSMLAFIPSPIFFGWVFDRVCLVWG-KTCTNKGNCWLYDPLSMRYTLNFTAAVFIAIGAIFDL 751
            .:...|..|.:||:||.:.|..|:.|. ..|..:|:|..|:..|.       :.|::.:.::..:
Human   577 MVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSF-------SRVYLGLSSMLRV 634

  Fly   752 G------VWYYAKDLKIFDEDVKEVEMKIVQHE---EEANNEKN 786
            .      :..||...|..::|:...|...|..|   |..|..|:
Human   635 SSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKH 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	178/657 (27%)
		MFS	114..>518	CDD:119392	110/419 (26%)
		KAZAL_SLC21	537..590	CDD:238650	30/72 (42%)
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	181/671 (27%)
		MFS	31..>427	CDD:119392	110/429 (26%)
		KAZAL_SLC21	455..508	CDD:238650	28/56 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820