DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp58Dc and slco1e1

DIOPT Version :9

Sequence 1:	NP_001097409.1	Gene:	Oatp58Dc / 37545	FlyBaseID:	FBgn0034716	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_009299376.1	Gene:	slco1e1 / 100332946	ZFINID:	ZDB-GENE-100818-2	Length:	695	Species:	Danio rerio

Alignment Length:	732	Identity:	194/732 - (26%)
Similarity:	311/732 - (42%)	Gaps:	139/732 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 IFSMTYAYFNGT---------ITTIEKRFKIPSKNTGIISVGNDISQTLVSAVLAYYAGKGHRPR 178
            |.::::|||:.|         ||.||:||.:.|...|::....::...|..||::::..:.||||
Zfish    36 IGALSFAYFSKTLCGTYMKSAITQIERRFDLSSSAVGLVDGSFEMGNLLFVAVVSHFGARLHRPR 100

  Fly   179 WIGFGLLTIVFFCILTTAPHFLYG-----------PGEDALALTSEFGGMPDENATMEAIEEQRS 232
            .||.|...:.....||..||...|           ..|..:....::...|.|: :::.|:
Zfish   101 LIGMGCFLMAIGSALTGLPHVFMGRYKFDTAIQGFANETVVIAPCQYPTNPSEH-SIQHID---- 160

  Fly   233 KTLCRLNGGGAECEVGEGNFAPQLLLFVAQFISGIGGSLYYTLGVSYMDDNTKKSKTPALLSLSY 297
                  |..|.:|....|: :..:.:|:...:.|||.:....||:||:||..|...:...:|...
Zfish   161 ------NTTGTDCVKDPGS-SMWIYVFLGNALRGIGETPVTPLGISYIDDFAKAENSAFYISCLQ 218

  Fly   298 FLRMLGPAIGYALASFCLRLYIAPQMHPV----INNKDPRWLGAWWLGWLVMGGLLSFSGVFLSM 358
            .:.:|||..|:.|.|.|.:||:......|    |..:|.||:||||||:.|....|..|||....
Zfish   219 TIMLLGPMFGFLLGSMCAKLYVDIGFVSVDSVSITPQDARWVGAWWLGFFVSSAFLVLSGVPFWF 283

  Fly   359 FPKELPRAVARRKVEENRRREKERLSVKSTEKERLTAELDQ-KTTAEAKASFQDMLKTFRRLITN 422
            .|:.||     ::.||    |||..:.....||....:... .|.|:....|   |.:.:||:..
Zfish   284 LPRSLP-----KQGEE----EKEICNTDDANKEHSVLQTTHTMTLADIAKGF---LPSLKRLLCT 336

  Fly   423 KTY---MCNTLSSIFYLVGYTPYWIFTPKYIEVQYRQSAATSSMVTGTVALAFSAVGVLLSGFII 484
            ..|   :|..:......:|..   .|..||:|.|:.|||:.::.:.|.:.|...|||:.|.|.::
Zfish   337 PAYFLLLCGIVLKFNSFIGLL---TFKAKYMEQQFGQSASRANFLIGVLILPVVAVGIFLGGLLM 398

  Fly   485 SRYKPRARYMAAWNVIVGF----------------LTVAGILAYAFIGCPGNESSVIVNIHDSSL 533
            .|||......|..:.|..|                :.||| |..::.|.|...|.      ..||
Zfish   399 KRYKLSVVAGAQLSFITSFTAFLLLLLHFGTKCDNVPVAG-LTVSYNGTPYMPSD------QRSL 456

  Fly   534 AGNTTTCNSACSCDYVRYSPVCGENNMTYISACHAGCKKLLVNSEGKK-IFYDCSCI--PSD-DA 594
               .:.||..|||....:.|||.::.:||:|.|.|||  .....:||. :|::|||:  ||. :.
Zfish   457 ---ESQCNQDCSCSTSEWDPVCSDSGITYMSPCLAGC--TASTGQGKNTVFHNCSCVLSPSPAEG 516

  Fly   595 GNSTSQFKRLTSFDLSNDEVSQNTSVHSQLEALANGQAMPGACPVN--CWTQFVAFLAVMCCLKF 657
            |.|.|.                                  |.||..  |...|.:::||.....|
Zfish   517 GRSVSL----------------------------------GQCPQGSACARSFTSYMAVSVLSSF 547

  Fly   658 VGASGRASNFLVSVRCVPEKDKTAAMGFGMTLCSMLAFIPSPIFFGWVFDRVCLVWG-KTCTNKG 721
            :.:.|....:::.:||:..:.|:.|:|....:...|..||:||:||.:.|..||.|| |.|..:|
Zfish   548 INSLGTTPGYMIIIRCIAPELKSLALGIQTLVMRTLGGIPAPIYFGALIDSACLKWGLKKCGGRG 612

  Fly   722 NCWLYDPLSMRYT-LNFTAAV-----FIAIGAIFDLGVWYYAKDLKIFDE---DVKEVEMKIVQH 777
            .|.:||....|.. |:.|.|:     |..|..|..|...:..:::|...:   ...|:|::..:.
Zfish   613 ACRIYDSNMYRVIFLSLTTALSGCSYFFIIAVIVLLRRQFIKEEVKALQQMAGKQNEIELRSPEM 677

  Fly   778 EE------EANNEKNTE 788
            :.      :..::.|||
Zfish   678 QNPDGTKTDERDKNNTE 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Dc	NP_001097409.1	OATP	112..731	CDD:281175	180/658 (27%)
		MFS	114..>518	CDD:119392	118/438 (27%)
		KAZAL_SLC21	537..590	CDD:238650	21/55 (38%)
slco1e1	XP_009299376.1	OATP	34..622	CDD:281175	180/658 (27%)
		MFS	36..>288	CDD:119392	74/263 (28%)
		KAZAL_SLC21	456..508	CDD:238650	21/56 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920