Protein Alignment MAST4 and DBF20

DIOPT Version :10

• Sequence 1: XP_024301812.1
• Gene: MAST4 / 375449
• HGNCID: 19037
• Length: 2695
• Species: Homo sapiens
• Sequence 2: NP_015436.1
• Gene: DBF20 / 856227
• SGDID: S000006315
• Length: 564
• Species: Saccharomyces cerevisiae
• Alignment Length: 597
• Identity: 158/597 - (26%)
• Similarity: 256/597 - (42%)
• Gaps: 140/597 - (23%)

Human   444 MNHV--YKERFPKATAQMEE----RLKE-------IITSYSPDNVLPLADGVLSFTHHQIIELAR 495
            |:|:  |....||.|:...:    |..|       :..||.|
Yeast    16 MSHLGFYDLNIPKPTSPQAQYRPARKSENGRLTPGLPRSYKP----------------------- 57

Human   496 DCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEF 560
             | |...|....:|  :.|.|...||.::.|:|:...:...:..:.:            |..|::
Yeast    58 -C-DSDDQDTFKNR--ISLNHSPKKLPKDFHERASQSKTQRVVNVCQ------------LYFLDY 106

Human   561 DPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGL----NKDPLEEMAHLGNYDSGTAETPETD 621
            ..:.|.|::...: ..|:       :.||:..|..:    ||...||.|..
Yeast   107 YCDMFDYVISRRQ-RTKQ-------VLRYLEQQRSVKNVSNKVLNEEWALY-------------- 149

Human   622 ESVSSSNASLKLRR-KPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQ 685
              :...:..|:.|| ||:..||:.:..:..|.||.||..:.|:|.:..|:|.:||:.|...|:..
Yeast   150 --LQREHEVLRKRRLKPKHKDFQILTQVGQGGYGQVYLAKKKDSDEICALKILNKKLLFKLNETN 212

Human   686 QAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETV 750
            ....||||||...:.::|.:..:|:....|.:.||:|.|||..||:.|...|....||.|.:|..
Yeast   213 HVLTERDILTTTRSDWLVKLLYAFQDPESLYLAMEFVPGGDFRTLLINTRILKSGHARFYISEMF 277

Human   751 LALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGL-----SKVGLMSMTTNLYE-GHIEKDA-- 807
            .|:..||..|..||||||:|.|:.:.||||||||||     |...:.||...|.| .::|..|
Yeast   278 CAVNALHELGYTHRDLKPENFLIDATGHIKLTDFGLAAGTVSNERIESMKIRLEEVKNLEFPAFT 342

Human   808 -REFLDKQ----------------VCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPF 855
             |...|::                :.|:|:|:|.||:..:.|...||:|::|.:|:|.|||..||
Yeast   343 ERSIEDRRKIYHNMRKTEINYANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPF 407

Human   856 FGDTPEELFGQVISDEINWPEKDEAPPPDAQ---------DLITLLLRQNPLERLGTGGAYEVKQ 911
            .|.:..|.:..:    ..|.:....|..:.:         ||||.|: .:|:.|:.:  ..:|::
Yeast   408 SGSSTNETYENL----RYWKKTLRRPRTEDRRAAFSDRTWDLITRLI-ADPINRVRS--FEQVRK 465

Human   912 HRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSC 976
            ..:|..:::.:|......|||||:.|.|..|||              |.||:||    :.:::..
Yeast   466 MSYFAEINFETLRTSSPPFIPQLDDETDAGYFD--------------DFTNEED----MAKYADV 512

Human   977 SHRFSKVFSSID 988
            ..|.:|:.:.:|
Yeast   513 FKRQNKLSAMVD 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST4	XP_024301812.1	DUF1908	330..603	CDD:462637	31/175 (18%)
		STKc_MAST	641..920	CDD:270760	100/312 (32%)
		PDZ_MAST4	1210..1304	CDD:467289
		PHA03247	<1883..2261	CDD:223021
		PHA03247	<2207..2506	CDD:223021
DBF20	NP_015436.1	MobB_Sid2p-like	77..164	CDD:439271	20/122 (16%)
		STKc_Sid2p_like	157..539	CDD:270751	124/393 (32%)