DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAST4 and DBF2

DIOPT Version :9

Sequence 1:	XP_024301812.1	Gene:	MAST4 / 375449	HGNCID:	19037	Length:	2695	Species:	Homo sapiens
Sequence 2:	NP_011606.3	Gene:	DBF2 / 852984	SGDID:	S000003324	Length:	572	Species:	Saccharomyces cerevisiae

Alignment Length:	453	Identity:	137/453 - (30%)
Similarity:	216/453 - (47%)	Gaps:	87/453 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   585 DIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRR----------KPRE 639
            |:..|:||:....|..||       |....::.|.:|:...:...|..|:|          ||:.
Yeast   117 DMFDYVISRRQRTKQVLE-------YLQQQSQLPNSDQIKLNEEWSSYLQREHQVLRKRRLKPKN 174

Human   640 SDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVS 704
            .|||.|..:..|.||.||..|.|::::..|:|.:||:.|...|:.:....||||||...:.::|.
Yeast   175 RDFEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVK 239

Human   705 MYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPD 769
            :..:|:..:.|.:.||:|.|||..||:.|...|....||.|.:|...|:..||:.|..||||||:
Yeast   240 LLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSGHARFYISEMFCAVNALHDLGYTHRDLKPE 304

Human   770 NLLVTSMGHIKLTDFGLS------------KVGLMSMTTNLYEGHIEK---DAREFLDK------ 813
            |.|:.:.||||||||||:            |:.|..:....:....||   |.|:..::
Yeast   305 NFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLREKEI 369

Human   814 ----QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEI-N 873
                .:.|:|:|:|.||:..:.|...||:|::|.:|:|.|||..||.|.:..|.:     |.: .
Yeast   370 NYANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETY-----DNLRR 429

Human   874 WPEKDEAP-PPDAQ--------DLITLLLRQNPLERLGTGGAYE-VKQHRFFRSLDWNSLLRQKA 928
            |.:....| ..|.:        ||||.|: .:|:.||   .::| ||:..:|..:::::|.....
Yeast   430 WKQTLRRPRQSDGRAAFSDRTWDLITRLI-ADPINRL---RSFEHVKRMSYFADINFSTLRSMIP 490

Human   929 EFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRIT 991
            .|.|||:||.|..|||              |.|::.|.           .:::.||...|::|
Yeast   491 PFTPQLDSETDAGYFD--------------DFTSEADM-----------AKYADVFKRQDKLT 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAST4	XP_024301812.1	DUF1908	330..603	CDD:312475	6/17 (35%)
		STKc_MAST	641..920	CDD:270760	104/314 (33%)
		PDZ_signaling	1218..1296	CDD:238492
		Atrophin-1	<1883..2261	CDD:331285
		Atrophin-1	<2207..2506	CDD:331285
DBF2	NP_011606.3	STKc_Sid2p_like	165..547	CDD:270751	124/398 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159049526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840