Protein Alignment MAST4 and KIN82

DIOPT Version :9

• Sequence 1: XP_024301812.1
• Gene: MAST4 / 375449
• HGNCID: 19037
• Length: 2695
• Species: Homo sapiens
• Sequence 2: NP_010015.3
• Gene: KIN82 / 850453
• SGDID: S000000687
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 797
• Identity: 203/797 - (25%)
• Similarity: 324/797 - (40%)
• Gaps: 214/797 - (26%)

Human   234 ARHRQRLVDPAASKKELSLPRRGSLIDSQKWNCLVKRLTPRSLSPTPSSPGSPCSPLLAFHFWSC 298
            ||:.:.|.:.|...|.:::            |||  .:...|||.:|||
Yeast    26 ARNLRSLQNNAPPGKNINV------------NCL--NVNSCSLSASPSS---------------- 60

Human   299 RTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPS 363
                :.::..||....||.|. ||.....:|...|..|...|...|    .|:.....:.||...
Yeast    61 ----QINMACNGNKQDLPIPF-PLHVECNDSWSSSKLNKFKSMFNH----NRSKSSGTTDASTSE 116

Human   364 SGYGTNTPSSTV-----SSSCSSQEKLHQ------LPYQ---PTPDELHFLSKHFCT--TESIAT 412
            .|.....|.||:     .||...:..:|.      :|.:   .||:|:...|.....  |..:.|
Yeast   117 KGTHKREPRSTIHTELLQSSIIGEPNVHSTTSSTLIPNEAICSTPNEISGSSSPDAELFTFDMPT 181

Human   413 ENRCRNTPMRPR-----SRSLSPGRSPACCDHEIIMMNHVYKERFPKATAQMEERLKEIITSYSP 472
            :....:||..|.     ||:||.|           .:|.:.:          .|.|:......|.
Yeast   182 DPSSFHTPSSPSYIAKDSRNLSNG-----------SLNDINE----------NEELQNFHRKISE 225

Human   473 D-NVLPLADGVLSFTHHQIIELARDCLDKSHQGLIT--SRYFLELQHKLDKLLQEAHDRSESGEL 534
            : :..|||:          :.|:...:|...:...|  .:..:.:..:|.:...|..:.::.|
Yeast   226 NGSASPLAN----------LSLSNSPIDSPRKNSETRKDQIPMNITPRLRRAASEPFNTAKDG-- 278

Human   535 AFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIISQLGLNKD 599
                 |:|:..|.:.:|..|.:.:|                .:..:.::|
Yeast   279 -----LMREDYIALKQPPSLGDIVE----------------PRRSRRLRT--------------- 307

Human   600 PLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKES 664
                 ...||........|::                     ||.|:|:..|..|.||.||.:::
Yeast   308 -----KSFGNKFQDITVEPQS---------------------FEKIRLLGQGDVGKVYLVRERDT 346

Human   665 RQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDC-- 727
            .|.||:|.:||..:|.|.:|::...|::||..:::||:|::|.||:|:.:|.:.|||..||:.
Yeast   347 NQIFALKVLNKHEMIKRKKIKRVLTEQEILATSDHPFIVTLYHSFQTKDYLYLCMEYCMGGEFFR 411

Human   728 ATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLM 792
            |...:....:..:.|:.|.:|.|.||||||..|.::|||||:|:|:...||:.|:||.||.....
Yeast   412 ALQTRKSKCIAEEDAKFYASEVVAALEYLHLLGFIYRDLKPENILLHQSGHVMLSDFDLSIQATG 476

Human   793 SMTTNLYEGHIEKDAREFLDKQVC----------GTPEYIAPEVILRQGYGKPVDWWAMGIILYE 847
            |....:      ||: .:||.::|          ||.||:|||||...|:...||||.:||::||
Yeast   477 SKKPTM------KDS-TYLDTKICSDGFRTNSFVGTEEYLAPEVIRGNGHTAAVDWWTLGILIYE 534

Human   848 FLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGT-GGAYEVKQ 911
            .|.||.||.||...|.|..:::.::.:|. |:....:.:|||..||.:|..:|||: .||.::|:
Yeast   535 MLFGCTPFKGDNSNETFSNILTKDVKFPH-DKEVSKNCKDLIKKLLNKNEAKRLGSKSGAADIKR 598

Human   912 HRFFRSLDWNSLLRQKAEFIPQLE---------------------SEDDTSYFDTRSEKYHHMET 955
            |.||:.:.|:.|..|....||.|.                     ||.:|..|         .|.
Yeast   599 HPFFKKVQWSFLRNQDPPLIPALNDNGCELPFILSCNKHPKRNSVSEQETKMF---------CEK 654

Human   956 EEEDDTNDE-----DFN 967
            ...||..||     |||
Yeast   655 VANDDEIDEADPFHDFN 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST4	XP_024301812.1	DUF1908	330..603	CDD:312475	49/296 (17%)
		STKc_MAST	641..920	CDD:270760	111/291 (38%)
		PDZ_signaling	1218..1296	CDD:238492
		Atrophin-1	<1883..2261	CDD:331285
		Atrophin-1	<2207..2506	CDD:331285
KIN82	NP_010015.3	STKc_phototropin_like	322..623	CDD:270726	117/329 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3124
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940