DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAST4 and dop

DIOPT Version :9

Sequence 1:	XP_024301812.1	Gene:	MAST4 / 375449	HGNCID:	19037	Length:	2695	Species:	Homo sapiens
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	2261	Identity:	758/2261 - (33%)
Similarity:	1012/2261 - (44%)	Gaps:	676/2261 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGEKVSEAPEPVPRGCSGHG-----SRTPASALVAASSPGASSAESSSG---SETLSEEGEPGGF 57
            :|.|:|.:   .|:....|.     :::.||.:.|.|...::|||||||   :.|.:..|.|  .
  Fly    36 LGSKISTS---TPQKNDEHQEQEFINQSVASEIEAMSISDSASAESSSGATATATATMSGSP--V 95

Human    58 SREHQPPPPPPLGGTLGARAPAAWAPASVLLERGVLALPPPLPGGAVPPAPRGSSASQEEQDEEL 122
            .:.|           |.....:...|.|....|.::.........|...|...:|:|.....:..
  Fly    96 PKRH-----------LSTANLSRIRPQSSYSARVLIFDDSDQEAAAAAAALAAASSSCNSSVKSC 149

Human   123 DHILSPPPMPFRKCSNPDVASGPGKSLKYKRQLSEDGRQLRRGSLGGALTGMDER--SNCWRYLL 185
            ..:...|..|.:.....|  |..|.|:.....|::..    .|.|.|:.:.:..|  :...|.:.
  Fly   150 SGLELLPTSPAKLSIGND--STNGSSMMRNLNLTKSS----SGGLSGSSSSLHSRGYTALLRKIS 208

Human   186 PNPVAGQAWPASAETSNLVRMRSQALGQSAP---------SLTASLEGQPPKSHFNSARHRQRLV 241
            ...........|.|||||:|||..:||:|||         .|||.|..|||  .|.::
  Fly   209 YQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQPP--GFGAS------- 264

Human   242 DPAASKKELSLPRRGSLIDSQKWNC----LVKR--------LTPRSLSPTPSSPGSPCSPLLAFH 294
                       |..|..| |:..:|    |.|.        :..|..:...:..|...|..:|.|
  Fly   265 -----------PLGGHNI-SRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGGAGSGGGSSSGVAHH 317

Human   295 FWSCRTSNRKSLIGNGQSPAL---PRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFA--RR---- 350
                    |.||:.|..:.|.   .|.|||.||    ||.||||..||..   |:||  :|
  Fly   318 --------RLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPRLNSPMP---FAFAPIKRIASC 367

Human   351 ----TDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL----------------------- 388
                .||||||:||||||||||...||.:||.|||||.|:||
  Fly   368 RGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCA 432

Human   389 -----------------------PYQPTPDELH------FLSKHFCTTESI-------------- 410
                                   |..|.|.:|.      ....:.|...|:
  Fly   433 EHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANG 497

Human   411 -ATENRCRNTPM----------RPRSRSL-SPGRSPACCDHEIIMMNHVYKERFPKATAQMEERL 463
             ::.|...::.|          ||||||| ||.||| ..|:||.:||.:|||||||||.||||||
  Fly   498 GSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSP-IVDNEIAVMNTLYKERFPKATQQMEERL 561

Human   464 KEIITSYSPDNVLPLADG--VLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAH 526
            |..|............|.  ::.|.|||::|:|||||.||...||||:||.||...|::||.|..
  Fly   562 KLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETK 626

Human   527 DRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYII 591
            ::|... .|.:..:::|:|::|:|||||||||||||:|||.||||||||||....||.|||:|||
  Fly   627 EKSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYII 690

Human   592 SQLGLNKDPLEEM---------------------AHLG--------------------------N 609
            .:||||:||:.|:                     .|.|                          :
  Fly   691 HKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMD 755

Human   610 YDSGTA---ETPET-------------------DESVSSSNA-----SLKL-------------- 633
            ..||||   :.|:|                   :|...||:|     |.|:
  Fly   756 SGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATA 820

Human   634 ------RRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERD 692
                  :..|:|:||:.:||||||||||||.|:||.:|||||||||||.|||||||::|.|.|||
  Fly   821 TGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERD 885

Human   693 ILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLH 757
            ||:||:|||||||||||||::|||:||||||||||.||:||:||||.||||.||||||||:||||
  Fly   886 ILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLH 950

Human   758 NYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYI 822
            :||||||||||||||:|::||||||||||||:||||:.||||||:|:.:.|:|.||||.||||||
  Fly   951 SYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYI 1015

Human   823 APEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP-PPDAQ 886
            |||||||||||||||||:|||||||||:|||||||:|.||||...::|:|.||:.::.| ..:|:
  Fly  1016 APEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAK 1080

Human   887 DLITLLLRQNPLERLGT-GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKY 950
            |:|:.||:|||.:|||| .||.|:|:|.:|..:||||||||||||:|||..:|||||||||.::|
  Fly  1081 DIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRY 1145

Human   951 HH-METEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRITQN--------SAEEKEDSVDKTK 1006
            :| :..|:.|||:|                 :.||.|.:..|..        |......|.|..|
  Fly  1146 NHDLGGEDTDDTDD-----------------TPVFGSFNSYTPQYRKQHYSWSRHATPTSTDGAK 1193

Human  1007 STTLPSTETLSWSSEYSEMQQLSTSNSSDTESNRHKLSSGLLPKL-----------------AIS 1054
            .|..|...:|.     |..|:...:....|       |:|.||||                 :.|
  Fly  1194 PTGPPPLSSLP-----SRAQETPAATVGAT-------STGALPKLKSGMGSGSGSGSGSGSGSAS 1246

Human  1055 TEG------------EQDEAASC---PGDP----------------------------------- 1069
            .:|            :.|.::||   |..|
  Fly  1247 HDGVVNKFLNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGAT 1311

Human  1070 ------HEEP-------GKPALPPEECAQEEPEVTTPASTISSSTLSVGSFS-----EHLDQING 1116
                  |..|       ..||.||....|.....|.|.:|:.|.:.|....|     :...|||.
  Fly  1312 QRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINR 1376

Human  1117 RSECV----------------------DSTDNSSKPSSE---PASHMARQRLESTEKKKI----S 1152
            :.:.|                      .||:|.:.|..:   ...|..:....||....:    |
  Fly  1377 KRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRS 1441

Human  1153 GKVTKSLSASALSLM--IPGDMFAVSPLG--SPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQP 1213
            ..:.||.||..||||  :.....|....|  ||....: .|..:||||:||.|:.|....:...|
  Fly  1442 RSIVKSASALGLSLMTSLDNSQLAAQLCGIQSPGGGGN-GSSTASSRDTSPCRELSPLVTNLKPP 1505

Human  1214 IVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLV 1278
            |:|....:.:|||:..||||.||:|.||:||:|..|:|||||.:|||:..|||||:|||.|.||.
  Fly  1506 IIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLF 1570

Human  1279 HTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMV-----RRSKKSKKKESLERRRSL 1338
            ||:|::|||..|..|::..||.|:|||::|..:|:..:|::.     |:.|::|::...:|:.||
  Fly  1571 HTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSL 1635

Human  1339 FKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPT-HSLSPRSPTPSYRSTPDFPSGTNSSQSS 1402
            |:::         :|:..:...:..|:|.|.|.:|: .:|||..  .||.|:....:..:||||:
  Fly  1636 FRRI---------SSKRANAEMQQYSAGTSSPTTPSARNLSPLD--SSYHSSCCQSAANSSSQST 1689

Human  1403 SPSSSAPNSPAGSG-----------------------------------HI-------------- 1418
            |||||:||:|.||.                                   |:
  Fly  1690 SPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNV 1754

Human  1419 -------------RPSTLHGLAPKL--------GGQRYRS-----------------GRRKSAGN 1445
                         ||||||||..||        ||....:                 .||||.|:
  Fly  1755 PVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGH 1819

Human  1446 IPLSPLARTPSPTPQPTSPQRSPS----PLLGHSLGNSKIAQAFPSKMHSP----PTIVRHI--- 1499
            ||||||||||||:|.|:||.||||    ||:||..|.|...|::     ||    ||:...:
  Fly  1820 IPLSPLARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY-----SPGSTLPTLQTAVNAN 1879

Human  1500 ------VRPKSAEPPRSPLLKRVQSEEKLSPSYGSDK-KHLCSRKHSLEVTQEEV---------- 1547
                  .|.|||| |.||||:|..|.::|.|.....| ..||......:.|.:.|
  Fly  1880 TKKAGFARTKSAE-PSSPLLRRALSPDRLHPRSAETKISPLCCSPPIKQPTHQRVVTTTWRSTPG 1943

Human  1548 ------------------------QREQSQREAPLQSL--------DENVCDVPPLSRARPVEQG 1580
                                    ..|:|||:..:.::        |.:...|..|:...|:.:
  Fly  1944 GSASGAGGAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDPSATAVVTLANCEPLPR- 2007

Human  1581 CLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQESHQKSHGPGSDLENFALFKLEERE 1645
                                        :.::.|.....|:|...|.|....:|.||     |.|
  Fly  2008 ----------------------------IAEEKDSPTSTQDSSSVSEGFMPAIEEFA-----EGE 2039

Human  1646 KKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQASVRASEGAMSDGRVPAEHRQGGG---- 1706
            ....|.......|........|..|.|.          |.:..:|..:....|.......|
  Fly  2040 SSSSPTQTLEKPTKVKATEQPEMEPAGK----------SKKVDQGKTTTPGTPKTKPHNSGCKTS 2094

Human  1707 -----------DFRRAPAPGT--LQDGLCHSLDRGISGKGEGTEKSSQAKE 1744
                       ....||...|  :..|       |.||.| |:..:|.||:
  Fly  2095 MTTTKPASPSVTISTAPRKDTSAVTGG-------GSSGSG-GSAATSAAKQ 2137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAST4	XP_024301812.1	DUF1908	330..603	CDD:312475	151/362 (42%)
		STKc_MAST	641..920	CDD:270760	205/280 (73%)
		PDZ_signaling	1218..1296	CDD:238492	43/77 (56%)
		Atrophin-1	<1883..2261	CDD:331285
		Atrophin-1	<2207..2506	CDD:331285
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	151/362 (42%)
		STKc_MAST	834..1115	CDD:270760	205/280 (73%)
		S_TKc	835..1110	CDD:214567	203/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	45/80 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154020
Domainoid	1	1.000	441	1.000	Domainoid score	I548
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	982	1.000	Inparanoid score	I312
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41421
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3124
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790