DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAST4 and kin-4

DIOPT Version :9

Sequence 1:XP_024301812.1 Gene:MAST4 / 375449 HGNCID:19037 Length:2695 Species:Homo sapiens
Sequence 2:NP_001255551.1 Gene:kin-4 / 178068 WormBaseID:WBGene00002192 Length:1831 Species:Caenorhabditis elegans


Alignment Length:1857 Identity:637/1857 - (34%)
Similarity:878/1857 - (47%) Gaps:450/1857 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     2 GEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSEEGEPGG---------- 56
            |:....:||....|....|:..| |..:::..|...::.:|:.|:|.|....|..          
 Worm    97 GQADDNSPEFRGGGAFLFGNNLP-SRFLSSPPPDRRTSFASTMSDTNSSITIPMSSSYQNLLSPM 160

Human    57 ------FSREHQPPPPPP----LGGTLGARA--------PAAWAPASVLLERGVLALPPPLPGGA 103
                  .|.:::.||..|    ....|..|:        |..::|   :|.|.:.::.|.:   :
 Worm   161 WSTMKYSSDDNETPPNEPSPRRSKSALSNRSSSDCINVPPIVFSP---VLSRPIRSMSPTM---S 219

Human   104 VPPAPRGSSASQEEQDEELDHILSPPPMPFRKCSNPD---VASGPGKSLKYKRQLSEDGRQLRRG 165
            :.|..|    :....|.|.|.......:....|::..   |..|.|..:...|      |...|.
 Worm   220 MSPTFR----THHNSDSESDTGAQAAGVCLFACTSSASGLVWKGSGSLMIPPR------RSFHRP 274

Human   166 SLGGALTGMDERSNCWRYLLPN----------------PVAGQAWPASAETSNLVRMRSQALGQS 214
            ..||.....|..||..|.|..|                ..|...| .||..:||.|:|| :||.|
 Worm   275 QGGGGNDSSDSNSNVERLLKRNRRRTMAIHGVETEPGQTAASTGW-TSASMTNLCRVRS-SLGHS 337

Human   215 APSLTASLEGQPPKSHFNSARHRQRLVDPAASKKELSLPRRGSLIDSQKWNCLVKRLTPRSLSPT 279
            .|.|::|     ..:.||::...   :.||......:|                      |...|
 Worm   338 DPQLSSS-----STNSFNTSTSS---LHPATKSSTTAL----------------------SSFST 372

Human   280 PSSPGSPCSPLLAFHFWSCRTSNRKSLIGNGQSPALPRPHSPL--------SAH----AGNSPQD 332
            .|:..||              :||.||..:.....|.|..||:        |:|    ||..|..
 Worm   373 SSANRSP--------------ANRPSLHSSTSPVTLQRCRSPMRVPQRSTSSSHNFGAAGAGPSS 423

Human   333 SPRNFSPSASAHF---------SFARRT---------DGRRWSLASLPS-SGYGT--NTPSSTVS 376
            |      .:|.|.         :::.|.         |.|||||||||| |||||  ...:|.||
 Worm   424 S------GSSVHSGTITLSVCRTYSARNGSSLMAPVQDTRRWSLASLPSTSGYGTPGTGSNSGVS 482

Human   377 SSCSSQEKLHQLPYQ--------------PTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRS 427
            |..||.|::.::..|              .:.|....::.|    :..|.:|...|   ||||||
 Worm   483 SQYSSSEQIGEMLDQTRISGPVRQNSSRFDSNDSYDDMASH----QQAAAQNAFLN---RPRSRS 540

Human   428 LSPGRSPA--CCDHEIIMMNH--VYKERFPKATAQMEERLKEIIT-------------------- 468
            |:   ||.  ..::.|.|:|.  |||||||:|..||||||...:.                    
 Worm   541 LT---SPMKFLNEYNIEMVNRTSVYKERFPRAKLQMEERLNAFVAENGPLSGGISQQSARDDTDR 602

Human   469 -------------------------------------SYSPDNVLPL-ADGVLSFTHHQIIELAR 495
                                                 ||:..::|.| .||...|.||||:|:|.
 Worm   603 VDDLSARQSGSSSGLKAKDSVEEAVMRSRRSTVLEAESYADRSLLRLIGDGATRFLHHQIVEIAL 667

Human   496 DCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEF 560
            |||.||...|||..||.|:..:|::.|.||..::....|.::.:||:|:|::::|||||||||||
 Worm   668 DCLGKSKDDLITCSYFCEMSQRLEETLNEAQMKTSPESLEYLSKLVKKLLMIVSRPARLLECLEF 732

Human   561 DPEEFYYLLEAAEGHAKEGQGIKT----DIPRYIISQLGLNKDPL-EEMAHLGNYDSGTAETPET 620
            ||:|||:|||.|||..:|..|..|    |:|:|||.:|||::||| :...|:.:.::..|.|..|
 Worm   733 DPDEFYHLLEEAEGVVREQLGSGTARVPDLPQYIIGKLGLDRDPLIDSTEHVDSSENTHATTSGT 797

Human   621 DESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQ 685
            ..:..:.:|..:..|.|.|.||:||:|:|||||||||.|||:|:|||||:||:|||.|:||||:.
 Worm   798 TSAKGAGSAWQETNRAPCEDDFDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVD 862

Human   686 QAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETV 750
            |.|.||||||.|:||||||.|.|||||::|||:||||||||||.|:|:.|.|||::.|:|.|||:
 Worm   863 QVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPVELVRLYVAETI 927

Human   751 LALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDA----REFL 811
            ||:||||:||||||||||||||:|:|||||||||||||:|||:.||.:.||:   ||    ::|.
 Worm   928 LAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGY---DAVVETQQFQ 989

Human   812 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPE 876
            |||:||||||||||||||:||||||||||:||||||||||.|||||:|||.||.:|||:::.:||
 Worm   990 DKQLCGTPEYIAPEVILRRGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPE 1054

Human   877 KDEAPPPDAQDLITLLLRQNPLERLGT-GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDT 940
            :|||.||:|.||...||.:||.||||| .||.::..|.||..||:.|||||||||:|||::|:||
 Worm  1055 EDEALPPEAADLCRRLLEKNPAERLGTLNGAAQLMAHEFFILLDFTSLLRQKAEFVPQLDNEEDT 1119

Human   941 SYFDTRSEKYHHMETEEEDDTNDEDF-------NVEIRQFSSCSHRFSKVFSSIDRI-------T 991
            ||||||:::|:|    |.:...:|:.       ::....||:.|.|.|.|  |||..       |
 Worm  1120 SYFDTRTDRYNH----EAESCGEEEIVGSSAASSMMFHSFSTASPRHSIV--SIDPAHLPHLLST 1178

Human   992 QNSAEEKEDSVDKTKSTTLPSTETLSWSSEYS------EMQQLSTSNSSDT-------ESNRHKL 1043
            .|:|.::   ::::.|.::.|.........||      |:.::...|:|..       .:.||.:
 Worm  1179 ANAAAKE---IERSHSVSMSSRPETRPERSYSTGQAPPELFKVGDDNTSTAVNLRRRFSAQRHNV 1240

Human  1044 S--------SGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSS 1100
            |        ||.....|.|:.....:|:|.|         ...||...:..|....:|....|.|
 Worm  1241 STTSSSGTGSGTCFATAASSTDSSIDASSLP---------LFQPPSRSSIAERGSRSPLPKFSIS 1296

Human  1101 TLSVGSFS----EHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSA 1161
            .......|    :|.|..:.|:..:.||     .||..|....|.|.:|      ||:.    .|
 Worm  1297 CEGEAGVSRSGDDHDDLDDSRNSTIVST-----ASSGGADETVRFRRQS------SGRT----PA 1346

Human  1162 SALSLMIPG------------------DMFAVSP---LGSPMSPHSLS-SDPSSSRD-SSP---- 1199
            |.|.|:||.                  .|:...|   :||.:||...| |..|||.| .||    
 Worm  1347 SQLQLVIPSISSSQSSQSAEPARETCYVMYPSGPSTSVGSQLSPGGASVSSASSSNDVGSPHPLP 1411

Human  1200 --------SRDSSAASAS--PHQPIVIHSSGKNYGFTIRAIRVYVGD-SDIYTVHHIVWNVEEGS 1253
                    |.||||||:|  |.:.|.|......:|||::::|||:|: |:.||:.|||..|.|||
 Worm  1412 LHHEHPLTSHDSSAASSSTAPSKTITIRKGPFGFGFTLKSVRVYLGEHSEYYTIEHIVTAVVEGS 1476

Human  1254 PACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSR 1318
            ||..|.|:|.|:|||:||.|||.|.|.:::..||.:||::.:...|..||||:.|.|||.  ..:
 Worm  1477 PAFHANLQAEDMITHVNGHPVHNLTHPQLMHRLLANGNELILRLVPLANTSIREGAARRT--VGK 1539

Human  1319 MVRRSKKSKKKESLERRRSLFKKLAKQPSPLLH---------------TSRSFSCLNRSLSSGES 1368
            |.|     ||.:..:||....:|..::||.||.               :|:..:.:.||.||.:.
 Worm  1540 MAR-----KKPKRPQRRVVPLEKKTRKPSALLRRLSGKRATNDIVPGSSSQKQAFMPRSASSQDG 1599

Human  1369 -----LPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSS--SAPNS------PAGSGHI-- 1418
                 |||:...|....|..||..|........|..:::.|||  |..||      ||.:..:  
 Worm  1600 CILTHLPGTSKISQQEASQEPSTSSQGMVRRSVNEIETNRPSSLRSTSNSHHHHHHPASTSSVAS 1664

Human  1419 RPSTLHGLAPKLGGQRYRSGRRKSAGN----------------------IPLSPLA-----RTPS 1456
            .|:||....|....:...|....||.|                      |.:||||     |:||
 Worm  1665 APATLPSTTPSNLSRMASSSPSSSASNSGTSSPAATSSGISIVKQKSQSIAVSPLARDTRMRSPS 1729

Human  1457 P---------TPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSP----------PTIVRHIVRP 1502
            |         :...|.|....:|....|..||...|...|...||          ||....::.|
 Worm  1730 PSHLHHRPASSSYTTRPDGVVTPATSSSPNNSGFVQDLISSRQSPNLSARRRSYQPTTTTSMIVP 1794

Human  1503 ---------KSAEPPRSPLLKRVQSEEKLSPSYGSDK 1530
                     .:|......||.|:..::..:...||.|
 Worm  1795 PTTHHLRGFSAAAQSAQDLLNRLLPKQDNNSDSGSKK 1831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAST4XP_024301812.1 DUF1908 330..603 CDD:312475 129/374 (34%)
STKc_MAST 641..920 CDD:270760 197/283 (70%)
PDZ_signaling 1218..1296 CDD:238492 37/78 (47%)
Atrophin-1 <1883..2261 CDD:331285
Atrophin-1 <2207..2506 CDD:331285
kin-4NP_001255551.1 DUF1908 455..779 CDD:286070 124/333 (37%)
STKc_MAST 818..1099 CDD:270760 197/283 (70%)
S_TKc 819..1094 CDD:214567 193/277 (70%)
PDZ_signaling 1434..1521 CDD:238492 39/86 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C161462425
Domainoid 1 1.000 404 1.000 Domainoid score I400
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 800 1.000 Inparanoid score I268
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm15440
orthoMCL 1 0.900 - - OOG6_100724
Panther 1 1.100 - - O PTHR24356
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3124
SonicParanoid 1 1.000 - - X479
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
99.010

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