Protein Alignment MAST4 and kin-4

DIOPT Version :10

• Sequence 1: XP_024301812.1
• Gene: MAST4 / 375449
• HGNCID: 19037
• Length: 2695
• Species: Homo sapiens
• Sequence 2: NP_001255551.1
• Gene: kin-4 / 178068
• WormBaseID: WBGene00002192
• Length: 1831
• Species: Caenorhabditis elegans
• Alignment Length: 1857
• Identity: 637/1857 - (34%)
• Similarity: 878/1857 - (47%)
• Gaps: 450/1857 - (24%)

Human     2 GEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSEEGEPGG---------- 56
            |:....:||....|....|:..| |..:::..|...::.:|:.|:|.|....|..
 Worm    97 GQADDNSPEFRGGGAFLFGNNLP-SRFLSSPPPDRRTSFASTMSDTNSSITIPMSSSYQNLLSPM 160

Human    57 ------FSREHQPPPPPP----LGGTLGARA--------PAAWAPASVLLERGVLALPPPLPGGA 103
                  .|.:::.||..|    ....|..|:        |..::|   :|.|.:.::.|.:   :
 Worm   161 WSTMKYSSDDNETPPNEPSPRRSKSALSNRSSSDCINVPPIVFSP---VLSRPIRSMSPTM---S 219

Human   104 VPPAPRGSSASQEEQDEELDHILSPPPMPFRKCSNPD---VASGPGKSLKYKRQLSEDGRQLRRG 165
            :.|..|    :....|.|.|.......:....|::..   |..|.|..:...|      |...|.
 Worm   220 MSPTFR----THHNSDSESDTGAQAAGVCLFACTSSASGLVWKGSGSLMIPPR------RSFHRP 274

Human   166 SLGGALTGMDERSNCWRYLLPN----------------PVAGQAWPASAETSNLVRMRSQALGQS 214
            ..||.....|..||..|.|..|                ..|...| .||..:||.|:|| :||.|
 Worm   275 QGGGGNDSSDSNSNVERLLKRNRRRTMAIHGVETEPGQTAASTGW-TSASMTNLCRVRS-SLGHS 337

Human   215 APSLTASLEGQPPKSHFNSARHRQRLVDPAASKKELSLPRRGSLIDSQKWNCLVKRLTPRSLSPT 279
            .|.|::|     ..:.||::...   :.||......:|                      |...|
 Worm   338 DPQLSSS-----STNSFNTSTSS---LHPATKSSTTAL----------------------SSFST 372

Human   280 PSSPGSPCSPLLAFHFWSCRTSNRKSLIGNGQSPALPRPHSPL--------SAH----AGNSPQD 332
            .|:..||              :||.||..:.....|.|..||:        |:|    ||..|..
 Worm   373 SSANRSP--------------ANRPSLHSSTSPVTLQRCRSPMRVPQRSTSSSHNFGAAGAGPSS 423

Human   333 SPRNFSPSASAHF---------SFARRT---------DGRRWSLASLPS-SGYGT--NTPSSTVS 376
            |      .:|.|.         :::.|.         |.|||||||||| |||||  ...:|.||
 Worm   424 S------GSSVHSGTITLSVCRTYSARNGSSLMAPVQDTRRWSLASLPSTSGYGTPGTGSNSGVS 482

Human   377 SSCSSQEKLHQLPYQ--------------PTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRS 427
            |..||.|::.::..|              .:.|....::.|    :..|.:|...|   ||||||
 Worm   483 SQYSSSEQIGEMLDQTRISGPVRQNSSRFDSNDSYDDMASH----QQAAAQNAFLN---RPRSRS 540

Human   428 LSPGRSPA--CCDHEIIMMNH--VYKERFPKATAQMEERLKEIIT-------------------- 468
            |:   ||.  ..::.|.|:|.  |||||||:|..||||||...:.
 Worm   541 LT---SPMKFLNEYNIEMVNRTSVYKERFPRAKLQMEERLNAFVAENGPLSGGISQQSARDDTDR 602

Human   469 -------------------------------------SYSPDNVLPL-ADGVLSFTHHQIIELAR 495
                                                 ||:..::|.| .||...|.||||:|:|.
 Worm   603 VDDLSARQSGSSSGLKAKDSVEEAVMRSRRSTVLEAESYADRSLLRLIGDGATRFLHHQIVEIAL 667

Human   496 DCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEF 560
            |||.||...|||..||.|:..:|::.|.||..::....|.::.:||:|:|::::|||||||||||
 Worm   668 DCLGKSKDDLITCSYFCEMSQRLEETLNEAQMKTSPESLEYLSKLVKKLLMIVSRPARLLECLEF 732

Human   561 DPEEFYYLLEAAEGHAKEGQGIKT----DIPRYIISQLGLNKDPL-EEMAHLGNYDSGTAETPET 620
            ||:|||:|||.|||..:|..|..|    |:|:|||.:|||::||| :...|:.:.::..|.|..|
 Worm   733 DPDEFYHLLEEAEGVVREQLGSGTARVPDLPQYIIGKLGLDRDPLIDSTEHVDSSENTHATTSGT 797

Human   621 DESVSSSNASLKLRRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQ 685
            ..:..:.:|..:..|.|.|.||:||:|:|||||||||.|||:|:|||||:||:|||.|:||||:.
 Worm   798 TSAKGAGSAWQETNRAPCEDDFDTIRLVSNGAYGAVYLVRHRETRQRFALKKMNKQTLMLRNQVD 862

Human   686 QAFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETV 750
            |.|.||||||.|:||||||.|.|||||::|||:||||||||||.|:|:.|.|||::.|:|.|||:
 Worm   863 QVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGDCAALLKSAGTLPVELVRLYVAETI 927

Human   751 LALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDA----REFL 811
            ||:||||:||||||||||||||:|:|||||||||||||:|||:.||.:.||:   ||    ::|.
 Worm   928 LAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGLMNRTTLVAEGY---DAVVETQQFQ 989

Human   812 DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPE 876
            |||:||||||||||||||:||||||||||:||||||||||.|||||:|||.||.:|||:::.:||
 Worm   990 DKQLCGTPEYIAPEVILRRGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVISEDVEYPE 1054

Human   877 KDEAPPPDAQDLITLLLRQNPLERLGT-GGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDT 940
            :|||.||:|.||...||.:||.||||| .||.::..|.||..||:.|||||||||:|||::|:||
 Worm  1055 EDEALPPEAADLCRRLLEKNPAERLGTLNGAAQLMAHEFFILLDFTSLLRQKAEFVPQLDNEEDT 1119

Human   941 SYFDTRSEKYHHMETEEEDDTNDEDF-------NVEIRQFSSCSHRFSKVFSSIDRI-------T 991
            ||||||:::|:|    |.:...:|:.       ::....||:.|.|.|.|  |||..       |
 Worm  1120 SYFDTRTDRYNH----EAESCGEEEIVGSSAASSMMFHSFSTASPRHSIV--SIDPAHLPHLLST 1178

Human   992 QNSAEEKEDSVDKTKSTTLPSTETLSWSSEYS------EMQQLSTSNSSDT-------ESNRHKL 1043
            .|:|.::   ::::.|.::.|.........||      |:.::...|:|..       .:.||.:
 Worm  1179 ANAAAKE---IERSHSVSMSSRPETRPERSYSTGQAPPELFKVGDDNTSTAVNLRRRFSAQRHNV 1240

Human  1044 S--------SGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSS 1100
            |        ||.....|.|:.....:|:|.|         ...||...:..|....:|....|.|
 Worm  1241 STTSSSGTGSGTCFATAASSTDSSIDASSLP---------LFQPPSRSSIAERGSRSPLPKFSIS 1296

Human  1101 TLSVGSFS----EHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSA 1161
            .......|    :|.|..:.|:..:.||     .||..|....|.|.:|      ||:.    .|
 Worm  1297 CEGEAGVSRSGDDHDDLDDSRNSTIVST-----ASSGGADETVRFRRQS------SGRT----PA 1346

Human  1162 SALSLMIPG------------------DMFAVSP---LGSPMSPHSLS-SDPSSSRD-SSP---- 1199
            |.|.|:||.                  .|:...|   :||.:||...| |..|||.| .||
 Worm  1347 SQLQLVIPSISSSQSSQSAEPARETCYVMYPSGPSTSVGSQLSPGGASVSSASSSNDVGSPHPLP 1411

Human  1200 --------SRDSSAASAS--PHQPIVIHSSGKNYGFTIRAIRVYVGD-SDIYTVHHIVWNVEEGS 1253
                    |.||||||:|  |.:.|.|......:|||::::|||:|: |:.||:.|||..|.|||
 Worm  1412 LHHEHPLTSHDSSAASSSTAPSKTITIRKGPFGFGFTLKSVRVYLGEHSEYYTIEHIVTAVVEGS 1476

Human  1254 PACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSR 1318
            ||..|.|:|.|:|||:||.|||.|.|.:::..||.:||::.:...|..||||:.|.|||.  ..:
 Worm  1477 PAFHANLQAEDMITHVNGHPVHNLTHPQLMHRLLANGNELILRLVPLANTSIREGAARRT--VGK 1539

Human  1319 MVRRSKKSKKKESLERRRSLFKKLAKQPSPLLH---------------TSRSFSCLNRSLSSGES 1368
            |.|     ||.:..:||....:|..::||.||.               :|:..:.:.||.||.:.
 Worm  1540 MAR-----KKPKRPQRRVVPLEKKTRKPSALLRRLSGKRATNDIVPGSSSQKQAFMPRSASSQDG 1599

Human  1369 -----LPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSS--SAPNS------PAGSGHI-- 1418
                 |||:...|....|..||..|........|..:::.|||  |..||      ||.:..:
 Worm  1600 CILTHLPGTSKISQQEASQEPSTSSQGMVRRSVNEIETNRPSSLRSTSNSHHHHHHPASTSSVAS 1664

Human  1419 RPSTLHGLAPKLGGQRYRSGRRKSAGN----------------------IPLSPLA-----RTPS 1456
            .|:||....|....:...|....||.|                      |.:||||     |:||
 Worm  1665 APATLPSTTPSNLSRMASSSPSSSASNSGTSSPAATSSGISIVKQKSQSIAVSPLARDTRMRSPS 1729

Human  1457 P---------TPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSP----------PTIVRHIVRP 1502
            |         :...|.|....:|....|..||...|...|...||          ||....::.|
 Worm  1730 PSHLHHRPASSSYTTRPDGVVTPATSSSPNNSGFVQDLISSRQSPNLSARRRSYQPTTTTSMIVP 1794

Human  1503 ---------KSAEPPRSPLLKRVQSEEKLSPSYGSDK 1530
                     .:|......||.|:..::..:...||.|
 Worm  1795 PTTHHLRGFSAAAQSAQDLLNRLLPKQDNNSDSGSKK 1831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST4	XP_024301812.1	DUF1908	330..603	CDD:462637	129/374 (34%)
		STKc_MAST	641..920	CDD:270760	197/283 (70%)
		PDZ_MAST4	1210..1304	CDD:467289	42/94 (45%)
		PHA03247	<1883..2261	CDD:223021
		PHA03247	<2207..2506	CDD:223021
kin-4	NP_001255551.1	DUF1908	455..779	CDD:462637	124/333 (37%)
		STKc_MAST	818..1099	CDD:270760	197/283 (70%)
		PDZ_MAST	1434..1525	CDD:467189	40/90 (44%)