|
Human 1 MGEKVSEAPEPVPRGCSGHGSRTPASALVAASSPGASSAESSSGSETLSE---EGEPGGFSREHQ 62
|..||.| |.|... .|...:||:.|||||:|||| :.:.||.|.:.:
Frog 1 MERKVLE--------CEGAAD---------GSDRSSSSSLSSSGSQTLSEGDMKPQSGGSSTDCE 48
Human 63 PPPPPPLGGTLGARAPAAWAPASVLLERGVLALPPPLPGGAVPPAPRGSSASQEEQDEELDHILS 127
:..:....|| ..|.:.|..|:|||||.|||
Frog 49 -------------------SERNAERRRG----------------QEGRAHSGAEEDEELDSILS 78
Human 128 PPPMPFRKCSNPDVASGPGKSLKYKRQLSEDGRQLRRGSLGGALTGMDERSNCWRYLLPNPVAGQ 192
||.|..||||||:|::...||:|||.|||:|||.|||||||||||| |||||...|.|
Frog 79 PPSMLCRKCSNPEVSTRSCKSVKYKSQLSDDGRILRRGSLGGALTG--------RYLLPAGAAQQ 135
Human 193 AWPASAETSNLVRMRSQALGQSAPSLTASLEGQPPKSHFNSARHRQRLVDPAASKKELSLPRRGS 257
.|.||.|.|||||||||||||||||||||| ||||||||||
Frog 136 VWSASTEASNLVRMRSQALGQSAPSLTASL-------------------------KELSLPRRGS 175
Human 258 LIDSQKWNCLVKRLTPRSLSPTPSSPGSPCSPLLAFHFWSCRTSNRKSLIGNGQSPALPRPHSPL 322
. ||||||||||:||.||||||.|||||||||||||||||:.||||||||||||
Frog 176 F------------LTPRSLSPTPTSPCSPCSPLYAFHFWSCRTSNRKSLIGSSQSPALPRPHSPL 228
Human 323 SAHAGNSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQ 387
|||.|:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog 229 SAHTGSSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQ 293
Human 388 LPYQPTPDELHFLSKHFCTTESIATENRCRNTPMRPRSRSLSPGRSPACCDHEIIMMNHVYKERF 452
|||||||||||||||||| |||||:::||| ||:|||||||||||:|||||||||||||||||||
Frog 294 LPYQPTPDELHFLSKHFC-TESIASDDRCR-TPLRPRSRSLSPGRTPACCDHEIIMMNHVYKERF 356
Human 453 PKATAQMEERLKEIITSYSPDNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHK 517
||||||||:||::|:|:||||:||||||||||||||||||||||||||||.||||||||||||.|
Frog 357 PKATAQMEDRLQDIVTNYSPDSVLPLADGVLSFTHHQIIELARDCLDKSHLGLITSRYFLELQQK 421
Human 518 LDKLLQEAHDRSESGELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGI 582
::|||.|||:||||||||||||||::|||||||||||||||||||||||||||||||||||||||
Frog 422 IEKLLHEAHERSESGELAFIKQLVQRILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGI 486
Human 583 KTDIPRYIISQLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKL 647
|||||||||||||||||||||:|.|.|||||||||||||||:||||.|||:||||.||||||:||
Frog 487 KTDIPRYIISQLGLNKDPLEEIALLSNYDSGTAETPETDESISSSNKSLKIRRKPCESDFETMKL 551
Human 648 ISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETR 712
||||||||||.|||||:||||||||||||||||||||||||||||||||||||||||||||||||
Frog 552 ISNGAYGAVYLVRHKETRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETR 616
Human 713 RHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMG 777
||||||||||||||||||:||:|||||||||||||||||||||||||||||||||||||||||||
Frog 617 RHLCMVMEYVEGGDCATLLKNIGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLVTSMG 681
Human 778 HIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMG 842
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog 682 HIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMG 746
Human 843 IILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAY 907
|||||||||||||||||||:|||||||||||||||::|||.|||||||||||||||||:||||||
Frog 747 IILYEFLVGCVPFFGDTPEDLFGQVISDEINWPEKEDAPPSDAQDLITLLLRQNPLERMGTGGAY 811
Human 908 EVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFNVEIRQ 972
|||||.||.:|||||||||||||||||||||||||||||||||||||||||||||||||::||||
Frog 812 EVKQHPFFCALDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHHMETEEEDDTNDEDFSMEIRQ 876
Human 973 FSSCSHRFSKVFSSIDRITQNSAEEKEDSVDKTKSTTLPSTETLSWSSEYSEMQQLSTSNSSDTE 1037
|||.||||||||||||::.|:..|||:||.||:|..:||..|:||||||||||||||.|.||:||
Frog 877 FSSSSHRFSKVFSSIDQLMQSKVEEKDDSTDKSKDLSLPPVESLSWSSEYSEMQQLSISTSSETE 941
Human 1038 SNRHKLSSGLLPKLAISTEGEQDEAASCPGDPHEEPGKPALPPEECAQEEPEVTTPASTISSSTL 1102
:.:...:..||||.|||::.|:||. |..:| :|..|....||:..||:.:.|||.| |||||:
Frog 942 NPKQCHNGSLLPKFAISSDIERDEL--CSEEP-KETEKSTHEPEDSPQEDLDATTPVS-ISSSTV 1002
Human 1103 SVGSFSEHLDQINGRSECVDSTDNSSKPSSEPASHMARQRLESTEKKKISGKVTKSLSASALSLM 1167
||.||||||||||||||..|||||||||::|..|||||||||:|||:|:|||||||:||||||||
Frog 1003 SVSSFSEHLDQINGRSESADSTDNSSKPANETTSHMARQRLENTEKQKMSGKVTKSISASALSLM 1067
Human 1168 IPGDMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIVIHSSGKNYGFTIRAIRV 1232
||||:::|||||||:||.|:|||| |||||||||:||.:|:||.|||:|.||||.:|||::||||
Frog 1068 IPGDVYSVSPLGSPISPLSISSDP-SSRDSSPSRESSISSSSPKQPIIIQSSGKKFGFTLQAIRV 1131
Human 1233 YVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITT 1297
:||||||||||||||:|||||.|.||||||||||||||||||||||||||||||||||:||:|||
Frog 1132 FVGDSDIYTVHHIVWSVEEGSAAYQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGSKVAITT 1196
Human 1298 TPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTSRSFSCLNRS 1362
|.|||||||||||||||||||||||:||:||||::|||||.||||||||||||||||||||||||
Frog 1197 TAFENTSIKTGPARRNSYKSRMVRRTKKTKKKENIERRRSFFKKLAKQPSPLLHTSRSFSCLNRS 1261
Human 1363 LSSGESLPGSPTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLA 1427
||||||||.||||||||||||||.||||||||||||||||||||||||||||||||||||||||.
Frog 1262 LSSGESLPASPTHSLSPRSPTPSCRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLG 1326
Human 1428 PKLGGQRYRSGRRKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSP 1492
|||||||||||||||||:||||||||||||||||.|||||||||.|||:||||....||:|||||
Frog 1327 PKLGGQRYRSGRRKSAGSIPLSPLARTPSPTPQPPSPQRSPSPLHGHSVGNSKATPNFPAKMHSP 1391
Human 1493 PTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAP 1557
||||||:|||||||||||||||||||||||||||..:|||||||||:||||:||:.::..||:..
Frog 1392 PTIVRHVVRPKSAEPPRSPLLKRVQSEEKLSPSYCCEKKHLCSRKHNLEVTKEEIHKQPLQRDLA 1456
Human 1558 LQSLDENVCDVPPLSRARPVEQGCLKRPVSRKVGRQESVDDLDRDKLKAKVVVKKADGFPEKQES 1622
||||:|||||||..:|.:||||||||||||||||||||:|:||::|||||:|:||.| .||:|:|
Frog 1457 LQSLEENVCDVPACTRVKPVEQGCLKRPVSRKVGRQESLDELDKEKLKAKIVMKKKD-LPERQDS 1520
Human 1623 HQKS---HGPGSDLENFALFKLEEREKKVYPKAVERSSTFENKASMQEAPPLGSLLKDALHKQAS 1684
..|. |...::|.|......:|:|.|.|...::|::..|::.:..|:...|.:.||.|.|...
Frog 1521 LLKQSLMHDLHNELGNPVTVAEQEKEDKSYQNLIKRTNLSEHRLTTYESRSGGIMFKDTLSKSVI 1585
Human 1685 VRASEGAMSDGRV------PAEHRQGGGDFRRAPAPGTLQDGLCHSLDRGISGKGEGTEKSSQAK 1743
.|::.|.| ||:: .||:.....:.::||: |.||.|..:.:..:|:|.|
Frog 1586 SRSNGGCM-DGQLHGHGPQAAENIHISCEIKKAPS----------SCDRVILSRDDNVDKASSA- 1638
Human 1744 ELLRCEKLDSKLANIDYLRKKMSLEDKEDNLCPVLKPKMTAGSHECLPGNP-VRPTGGQQEPPPA 1807
| .||.:.:|||.|||:||...|.|||.| :||.:...| ..|| |....
Frog 1639 ----C------TANSELIRKKKSLEEKESTFCLVLKSK----AHENIQAKPSFLPT----ESIAP 1685
Human 1808 SESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPGLVAPESPVRKSPSEYKLEGRSVSCLKP 1872
.::|..:.: .|...|||.||||...|.::..:|.|::..|.||||||||:|||.||||.|||
Frog 1686 LDNRTCLPN---VQSGTVSFAPLKASNSRCENNNDKSGVIHTELPVRKSPSEFKLEARSVSSLKP 1747
Human 1873 IEGTLDIALLSGPQASKTELPSPESAQSPSPSGDVRASVPPVLPSSSGKKNDTTS-ARELSPSSL 1936
|||||||||||||:..|||.. |:... |||.:.: |.::||:|.
Frog 1748 IEGTLDIALLSGPKVPKTEYT------------DILLE----------KKNQSVAKAEKISPNSK 1790
Human 1937 KMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGP--HPTARSPGTVMESNPQQREGSSPK 1999
. |..||.|.:.. ..:..|....:::.|::....:|.
Frog 1791 N---------------------------DVAFKSDNQNTLLFSSTSSSSVSLQTAPKRPIKENPN 1828
Human 2000 HQDHTTDPKLLTCLGQNL-HSPDLARPRCPLPPEASPSREKPGLR----ESSERGPPTARSERSA 2059
. ||..|| .:.::...| |.|.||||.||: ::::.|..|:....:|
Frog 1829 E-----------CLQSNLAAAAEICSNR-----EVSGSREKNGLQNQTADTAQSGLKTSSEGLTA 1877
Human 2060 ARADTCREPSMELCFPETAK-TSDNSKNLLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGP--- 2120
:.....:| ::.....|.| ..:..:|.:....:.|...:....:|...|..|.|...|..
Frog 1878 SAKGNGQE--VKSLLASTGKCLLEQKQNKICREMSDPSRASSAVKVEAILAKSGSTEKTDHALHG 1940
Human 2121 --GEARPPPRDNSSLHS-AGIPCEKELGKVRRG--------VEPKPEALLARRSLQPPGIESEKS 2174
|::||.|......:. .|:| |.|..:... |:.|.:..:.:.|.... .|.|:
Frog 1941 TGGKSRPAPVTKLCTNDCVGVP--KPLPVINANAPVLLDTKVDIKVKVAIQQESSSVN--SSSKT 2001
Human 2175 EKLSSF--PSLQKDGAK-EPERKE-----------------QPLQRHPSSIPPPPLTAKDL-SSP 2218
::::|. .|.:|:..: .|.:|| :|...:.||:| ..|:| ||.
Frog 2002 QEITSILKASPEKNNREFSPSKKETISLKAQYMAGSICSGSEPEASNKSSLP----CRKELKSSC 2062
Human 2219 AARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRS 2283
..:..|...|....:....:.|:.|..||.:.....|:..:.|||...: ..:.|.|....|.
Frog 2063 EQKSSCEQKSSCEQKSSCEQKSSCEQKSSCEQLNDSVSKSNISSSSTTK-ATNSGKPGVLEPQ-- 2124
Human 2284 LSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGGPSVPLH 2348
|.||:| ||.|:|......:..||.:.. ::|.|||| |
Frog 2125 ------SAGASK-KEMASQRTDVLLKVDKGANTL------SSPLSQNK----------------H 2160
Human 2349 ---TDRAPLDAKPQPTSGGRPLEVLEKPVHLPRPGHPGPSEPADQKL--------SAVGEKQTLS 2402
|::......|...:.........:.:| ..||...|......| |.:.||.:|.
Frog 2161 IVVTEKTTNSIPPSTVNIRNTTPAAMREIH--SSGHQAASSTCSSPLNPKECSAKSHLKEKTSLQ 2223
Human 2403 PKHPKPSTVKDCPTLCKQTDNRQTDKS----------PSQPAANTDRRAEGKKCTEALYAPAEGD 2457
||..:.:::| ...|:..| |.:| :..||||||| .:.|
Frog 2224 PKLTRTASIK---------SGIQSKHSAEGLGLGAAFPEKP--------QDCKCTEALY--VQSD 2269
Human 2458 KLEAGL--SFVHSENRLKGAERPAAGVGKGFPEARGKGPGPQKPPTEADKPNGMKRSPSATGQSS 2520
|.|:.. :....|.|....|:|.: ...|...|| |.|......|..||:. :.|||..|.
Frog 2270 KRESKFMPTVTTRETRKVTTEKPKS---VNSPNVTGK--GAQSKMDLIDAHNGVS-ALSATVSSP 2328
Human 2521 FRSTALPEKSLS-CSSSFPETRAGV-REASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEG 2583
....:|.:..|| |..: .|| |..:|::...|.||. ::....|:...||:...
Frog 2329 RTDVSLTKPRLSECPFN-----VGVERNENASNIVPSKAKK-----DVQLSPNKAGAKAESIS-- 2381
Human 2584 RTHMTKSDSLPSFRVSTLPLESHHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQPPPARKQ 2648
:||.:...|.::: |.: :||.: .:|.:| .|:
Frog 2382 ----SKSSAEKQFSLAS----------NCV-----------LTAAI----SRDQSP------NKK 2411
Human 2649 NVGRDVTKPSPAPNTDRPISLSNEKDFVVRQRRGKESLRSSPHKK 2693
||.:||.| :.|.:...|.:|::||| :..|::|||.|::|.|:|
Frog 2412 NVAKDVQK-AAAVSLGNPCALTSEKD-LKGQKQGKEGLQTSAHEK 2454
| 
