DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and Slco1a6

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_570092.1	Gene:	Slco1a6 / 84608	RGDID:	69304	Length:	670	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	178/713 - (24%)
Similarity:	304/713 - (42%)	Gaps:	97/713 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VADDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNI 85
            :.:.|||..:....|            ||...:|::....|....|::.||....:|.:|:||||
  Rat     1 MGEPEKRAGTHGIRC------------FAKIKVFLLALTWAYASKALSATYMNSMLTQIERRFNI 53

  Fly    86 PTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALR 150
            .|.|.|||....::..:....|:||:..:.|||..:.:|..::.:.|.::..||...|
  Rat    54 STSIVGLINGSFEVGNLLLIIFVSYFGRKRHRPIMIGIGCAVMGLGCFIISLPHFLMG------- 111

  Fly   151 LTEEYGMSESFGASLNITEKNDSLCHEKNSNCLERAGDYTPIV-----LFFIAQFIG----GIGC 206
               .|....:...:.|:: .|..||.|..:..|:...|....|     |.:|...:|    |||.
  Rat   112 ---RYEYETTISPTSNLS-SNSFLCMENRTQTLKPTQDPAECVKEMKSLMWIYVLVGNIIRGIGE 172

  Fly   207 SLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYID----PFKKPLITTN 267
            :.....|:||::|.:.|..:|..:......::.||.....:.|.|..:|:|    ......||..
  Rat   173 TPIMPLGISYIEDFAKSENSPFYIGILEVGKITGPIAAIWLGSFCATIYVDMGSVNTDDLTITPT 237

  Fly   268 DPRWMGAWWIGWIL---LTFILTISAVFV-GMFPKEMPRAKARRLKAD-GEEDIPLAGRS----F 323
            |.|.:||||||:::   |..:::|...|. ..||||.|...|...|.| |::....|...    .
  Rat   238 DTRCVGAWWIGFLVCAGLNILISIPFFFFPKTFPKEGPEDMANETKNDEGDKHREKAKEEKRGIT 302

  Fly   324 QDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSA 388
            :|....:|.|:.|.:|:..:|.|:|.:.|::..:.|.|||:|..|.:|:|.:....|.:.|....
  Rat   303 KDFFLFMKSLSCNPIYMLCVLTSVLQVNGFVSIFTFKPKYLEHHYGKSSSEAIFLMGLYTLPSVC 367

  Fly   389 AGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLCYVLVGCD----------------ESDRA 437
            .|.||||:::.|:|.:.:..|..::.:........||..::.||                ..|..
  Rat   368 VGYLISGFIMKKFKITLKKAAFISYCLGMSECLLSLCNFMLTCDNVPIAGLTTSYEGIQQSFDME 432

  Fly   438 NSLSIVPTGDSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAINELGKTIYTGCRCM---G 499
            |::..     .|:..|.|....:.|||....:.:|:.|.||| :|::......:...|.|:   |
  Rat   433 NTVLA-----DCNTRCSCLTKTWDPVCGDNGLAYITPCLAGC-EKSVGSGINMVLQDCSCIQSSG 491

  Fly   500 NVSSIISLSNVTSLASQSQIAMDGACPVDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPS 564
            |.|:::.|.|...               ||..:...||.:..|..|..:.......::.|||:.|
  Rat   492 NSSAVLGLCNKGP---------------DCANKLQYFLIITVFCSFFYSLSLIPGYMIFLRCMKS 541

  Fly   565 KDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWG-KTCSSKGNCWIYDTKSLRYTMNLVCA 628
            ::|:..:|..:....:|..|.:||.||.::|..||.|| :.|...|.|..|:..|.|.....:.|
  Rat   542 EEKSLGIGLQAFCMRILGGILAPIYFGVLIDRTCLHWGTQKCGEPGACRTYEINSFRSIYLGLPA 606

  Fly   629 SL---IFLGSFWNIGVWYHAK-----DMKVFDEDEKTVQAKQSDDIELKEKP---NDVVTKKK 680
            :|   .:|.:|:.:.:....:     :..|.|..|..:..|:|:..::...|   ||...|.|
  Rat   607 ALRGSSYLPAFFILRLMRKFQFPGDINSPVTDHVEMMLTEKESEHTDVHRSPQVENDGELKTK 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	156/607 (26%)
		MFS	55..>410	CDD:119392	102/376 (27%)
		KAZAL_SLC21	447..499	CDD:238650	14/54 (26%)
Slco1a6	NP_570092.1	oat	1..625	CDD:273279	168/667 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..295		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..670		7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920