DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and Slco1c1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_445893.1	Gene:	Slco1c1 / 84511	RGDID:	628660	Length:	716	Species:	Rattus norvegicus

Alignment Length:	713	Identity:	199/713 - (27%)
Similarity:	326/713 - (45%)	Gaps:	112/713 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NSSDTTCGFSIFRG-PALQ--RFATAHMFVIVYGIASCFLAMAFT--YFTGTITTMEKRFNIPTK 88
            ||:....|.|...| |:.:  |.....:.|.:..::..:.|.|.|  |...|||.:|:||:||:.
  Rat    15 NSAQPAGGPSFKAGYPSTEEARPCCGKLKVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSS 79

  Fly    89 ISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTE 153
            :.|:|....:|..:....|:||:.::.|||:.:..|.:::....:|:..|..|          .|
  Rat    80 LVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFF----------ME 134

  Fly   154 EYGMS--ESFGASLNITEKNDSLCHEKNSNCLERA---------GDYTPI-------VLFFIAQF 200
            :|...  |.:..|.|:| .|.|.|:.::|:...|:         .|...:       |..|:...
  Rat   135 KYSYEKYERYSPSSNLT-PNISPCYLESSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNL 198

  Fly   201 IGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLYID----PFKK 261
            :.|:|.:.....|::|:||.::.......:.....:.::||..||.:.|||.:||:|    ....
  Rat   199 LRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDH 263

  Fly   262 PLITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMPRAKARRLKADGEE------DIP--- 317
            ..||..||:|:||||:|:::..|:..::||.....||.:||:::|.......|      |.|
  Rat   264 ITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPKTLPRSQSREDSGSSSEKSKFITDDPVNY 328

  Fly   318 -LAGRS--------FQDMLDSLKRLASNKVYVYNMLASILY---LFGYMPYWIFTPKYIEIQYRQ 370
             :|.|.        .:|.|.|||.|..|.||:..:.||.:.   |||.:.|   .|||||.||.|
  Rat   329 QMAPREESMKIMEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTY---KPKYIEQQYGQ 390

  Fly   371 SASTSTMATGTWALGFSAAGILISGYVISKYK---PSARAMAAWNFVVDYLTVAGMLCYVLVGCD 432
            |:|.:....|...:...|.||...|.|:.|::   ..|..:...:.|..||.   .|....:||:
  Rat   391 SSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL---FLSLFALGCE 452

  Fly   433 ESDRANSLSIVPTG------------DSCSASCVCEYVYYAPVCSPENITFISACHAGCTDKAIN 485
            .|..| .|::...|            ..|::.|.|....:.|:|....||:.|||.|||  ::.:
  Rat   453 NSSVA-GLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYASACLAGC--QSSS 514

  Fly   486 ELGKT-IYTGCRCMGNVSSIISLSNVTSLASQSQIAMDGACPVD--CNKQFLIFLAVMCFLKFVG 547
            ..||. |::.|.|:|          ..:..|.:...|.|.|..|  |::.||.||.:.....:..
  Rat   515 RSGKNIIFSNCTCVG----------FAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTL 569

  Fly   548 ATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWG-KTCSSKGNC 611
            :.|.....:|.|||:..:.|:|:||..::...|||.||:|:.||.::|:.||.|| |.|.|:|:|
  Rat   570 SLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSC 634

  Fly   612 WIYDTKSLRYTMNLVCASLIFLG---SFWNIGVWYHAKDMKVFDEDEKTVQAKQSDDIELKEK 671
            .:||:.:.|:         |:||   ....:.|:.....:.|.   :|...:|:|..|..:||
  Rat   635 RLYDSHAFRH---------IYLGLTTLLGTVSVFLSTAVLLVL---KKKYVSKRSSFITAREK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	180/629 (29%)
		MFS	55..>410	CDD:119392	112/402 (28%)
		KAZAL_SLC21	447..499	CDD:238650	18/52 (35%)
Slco1c1	NP_445893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/10 (40%)
		OATP	44..642	CDD:281175	180/627 (29%)
		MFS	46..>459	CDD:119392	119/430 (28%)
		KAZAL_SLC21	476..529	CDD:238650	18/54 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920