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Protein Alignment Oatp58Db and SLCO5A1

DIOPT Version :10

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_112220.2	Gene:	SLCO5A1 / 81796	HGNCID:	19046	Length:	848	Species:	Homo sapiens

Alignment Length:	712	Identity:	198/712 - (27%)
Similarity:	326/712 - (45%)	Gaps:	110/712 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AGINVADDEKRLNSSDTTCGFSIFRGPALQRFATAHMFVIVYGIASCFLA-----------MAFT 70
            ||:  .|...|::.|.|   ||:  ..||..........:|...:.|||.           |...
Human    90 AGL--GDCNHRVDLSKT---FSV--SSALAMLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSG 147

  Fly    71 YFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASRGHRPRWVALGLIIIAIFCLLM 135
            |.:..|||:|:|:::.:..|||:....||..:....|:||:..||.||.|:|:|.::||....|.
Human   148 YLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALF 212

  Fly   136 LTPHIFYGPGEEALRLTEEYGMSESFGASLNITEKNDSLCHEKNSN-------CLERAG---DYT 190
            ..||....|          |.:.|     ||.:..||.||...||.       |.:.:|   .:.
Human   213 ALPHFISPP----------YQIQE-----LNASAPNDGLCQGGNSTATLEPPACPKDSGGNNHWV 262

  Fly   191 PIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGPAMGFSMVSLCLRLY 255
            .:.||..||.:.|:|.:..|..|.:|:|||.....:...|:....:..||||:|:.:..|.:..|
Human   263 YVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFY 327

  Fly   256 IDPFKKPLITTNDPRWMGAWWIGWIL--LTFILTISAVFVGMFPKEMP----RAKARRLKADGEE 314
            :||.....:..||||::|.||.|::|  :...|.|..:|.  |||::|    :.|.::...|...
Human   328 VDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFT--FPKKLPPRHKKKKKKKFSVDAVS 390

  Fly   315 DIPLA-------------------GRSFQDMLDSLKRLASNKVYVYNMLASILYLFGYMPYWIFT 360
            |..:.                   |:..:|:..:..|:.||..:::..|:..........:..|.
Human   391 DDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFI 455

  Fly   361 PKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGMLC 425
            ||:||.|:...||.:::.||...:..:..||::.||:|.|.|..||..|....:...::   :||
Human   456 PKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVS---LLC 517

  Fly   426 Y---VLVGCDESDRANSLSI---------VP----TGDSCSASCVCEYVYYAPVCSPENITFISA 474
            :   .:||| ||.....::|         :|    || ||:.:|.|:...|.|||..:.||:.:.
Human   518 FSTLFIVGC-ESINLGGINIPYTTGPSLTMPHRNLTG-SCNVNCGCKIHEYEPVCGSDGITYFNP 580

  Fly   475 CHAGCTDKAINELGKTIYTGCRCMGNVSSI----------ISLSNVTSLASQSQIAMDGACPVDC 529
            |.|||.:......|...||.|.|:.:...|          :.:..|.:..:::..|:.|.|...|
Human   581 CLAGCVNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTC 645

  Fly   530 NK--QFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGW 592
            |.  .||:||.:   :.|:.|..:.|.:::.||.|..:::.|:||...::...||:||:||.||.
Human   646 NTLIPFLVFLFI---VTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGA 707

  Fly   593 MLDSYCLVWGKTCSSKGNCWIYDTKSLRYTMNLVCASLIFLGSFWNIGVWYHAKDMKVFDED 654
            ::|:.|::|.:.|..:|:||.|:..|.|:....:.|.|.|:|..:....||..|    :.||
Human   708 VIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIK----YKED 765

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.