DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and slco1b3

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_031753845.1	Gene:	slco1b3 / 613085	XenbaseID:	XB-GENE-5943217	Length:	690	Species:	Xenopus tropicalis

Alignment Length:	606	Identity:	175/606 - (28%)
Similarity:	284/606 - (46%)	Gaps:	66/606 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MFVIVYGIASCF--LAMAF--TYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYAS 113
            ||:    :|.||  .|.||  :|...:||.:|:||:|.:...|:|....:|..:...|.:||:.:
Frog    42 MFL----VALCFSYFAKAFSGSYMKSSITQIERRFDISSSTVGMIDGSFEIGNLMVIAIVSYFGA 102

  Fly   114 RGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYG--MSESFGASLNITE--KNDSL 174
            :.||||.:|.|.|::::...|...||.|.|     |...|..|  .|.:..|::|::.  .|.||
Frog   103 QFHRPRIIAAGCILMSLGSFLTAMPHFFMG-----LYKYETVGGPTSLNSNATINVSPCLANRSL 162

  Fly   175 CHEKNSNCLERAGDYTPIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRML 239
            ......:|:...|.:..:.| .:...:.|||.:.....|:||:||.|....||..::....:.|.
Frog   163 VDTPKPDCVTENGSHMWVFL-LVGNILRGIGETPIAPLGISYLDDFSRPENTPLHIACLHTVAMF 226

  Fly   240 GPAMGFSMVSLCLRLYID----PFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEM 300
            ||..||.:.|...|||:|    ......||..|.||:||||||::|...:..:||:.....|:.:
Frog   227 GPMTGFMLGSFLARLYVDIGFVDTDTITITPQDTRWVGAWWIGFLLSGAVNLMSAIPFFFLPESL 291

  Fly   301 ---------PRAKARRLKADGEEDIPLAGRSFQDMLDSLKRLASNKVYVYNMLASILYLFGYMPY 356
                     |:.|....|...:::.|    :.:....:||.|..|:::|..|..::|....::.:
Frog   292 KEEQREGQKPQTKQGEEKGHKQKEKP----TLRGFFAALKTLCFNRLFVMLMCLTLLQTNSFLGF 352

  Fly   357 WIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVA 421
            ..:.|||:|.||.||.|.:...||...|..:|.|:.:.|.::.:||......:...:....|...
Frog   353 ITYKPKYMEQQYGQSISKANFVTGVSTLPAAALGMFLGGLIMKRYKFGLLGASKMAYGTSLLAFL 417

  Fly   422 GMLCYVLVGCDESDRANSLSIVPTGD--------------SCSASCVCEYVYYAPVCSPENITFI 472
            ..|....:||:.:   |...|..|.|              .|::.|.|....:.|||....:|::
Frog   418 LSLSAFFIGCENN---NVAGITVTYDRVKVNNFQDRIIYSPCNSDCHCSSKQWDPVCGENGVTYV 479

  Fly   473 SACHAGCTDKAINELGKTIYTGCRCMGNVSSIISLSNVTSLASQSQIAMDGACP--VDCNKQFLI 535
            |||.|||.....:.|| |:|..|.|:....|       |::.|.:.:   |:||  .||::.|:.
Frog   480 SACLAGCKASTGSGLG-TVYHNCSCIDTALS-------TAVNSSAHL---GSCPRGPDCSRMFMF 533

  Fly   536 FLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLV 600
            ::.......|:.|.|.||..:|.|..|..:.|:.::|...::...||.||:||.||.::|..||.
Frog   534 YVVTQAINTFIFALGASSAYVLLLWSVNPEMKSLAVGVYMLLIRTLAGIPAPIYFGAIIDKSCLK 598

  Fly   601 WG-KTCSSKGNCWIYDTKSLR 620
            || :.|..:|.|.:||..|.|
Frog   599 WGTRLCGGRGACRLYDADSFR 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	173/603 (29%)
		MFS	55..>410	CDD:119392	107/375 (29%)
		KAZAL_SLC21	447..499	CDD:238650	20/65 (31%)
slco1b3	XP_031753845.1	MFS_SLCO1B_OATP1B	40..558	CDD:341015	151/543 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010