DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp58Db and Slco1a1

DIOPT Version :9

Sequence 1:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_058807.1	Gene:	Slco1a1 / 50572	RGDID:	3700	Length:	670	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	177/691 - (25%)
Similarity:	313/691 - (45%)	Gaps:	95/691 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FATAHMFVIVYGIASCFLAMAFTYFTGTITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYA 112
            |:...:|::....|....:::..|....:|.:|::|:|.|.::|||....:|..:|...|:||:.
  Rat    16 FSKMKVFLLSLTCACLTKSLSGVYMNSMLTQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFG 80

  Fly   113 SRGHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGMSESFGASLNITEKNDSLCHE 177
            ::.|||..:.:|.:|:.:.||||..||.|.|          .|....:...:.|:: .|..||.|
  Rat    81 TKLHRPVVIGIGCVIMGLGCLLMSLPHFFMG----------RYEYETTISPTGNLS-SNSFLCME 134

  Fly   178 KNSNCLERAGDYTPIV-----LFFIAQFIG----GIGCSLFYAPGLSYMDDNSASSKTPAMLSWS 233
            ..:..|:...|....|     |.:|...:|    |||.:.....|:||::|.:.|..:|..:...
  Rat   135 NRTQTLKPTQDPAECVKEMKSLMWICVMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLYIGIL 199

  Fly   234 SFLRMLGPAMGFSMVSLCLRLYID----PFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVG 294
            ...::.||..|..:.|.|.::|:|    ......||.:|.||:||||||:::...:..::::...
  Rat   200 EMGKVAGPIFGLLLGSYCAQIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTSIPFF 264

  Fly   295 MFPKEMPRAKARR---LKADG----------EEDIPLAGRSFQDMLDSLKRLASNKVYVYNMLAS 346
            ..||.:|:...:.   :..||          ||::.:.    :|.|..:|||..|.:|:..:|.|
  Rat   265 FLPKALPKKGQQENVAVTKDGKVEKYGGQAREENLGIT----KDFLTFMKRLFCNPIYMLFILTS 325

  Fly   347 ILYLFGYMPYWIFTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAW 411
            :|.:.|::..:.|.|||:|.||.:|.:.:....|.::|.....|.||.|:::.|:|.:.:..|..
  Rat   326 VLQVNGFINKFTFLPKYLEQQYGKSTAEAIFLIGVYSLPPICLGYLIGGFIMKKFKITVKKAAYL 390

  Fly   412 NF---VVDYLTVAGMLCYVLVGCDESDRANSLSIVPTG------------DSCSASCVCEYVYYA 461
            .|   |.:||.   .||:.::.||.:..| .|:....|            ..|:..|.|....:.
  Rat   391 AFCLSVFEYLL---FLCHFMLTCDNAAVA-GLTTSYKGVQHQLHVESKVLADCNTRCSCSTNTWD 451

  Fly   462 PVCSPENITFISACHAGCTDKAINELGKTIYTGCRC---MGNVSSIISLSNVTSLASQSQIAMDG 523
            |||....:.::|||.||| .|.:......::..|.|   :||.|:::                 |
  Rat   452 PVCGDNGVAYMSACLAGC-KKFVGTGTNMVFQDCSCIQSLGNSSAVL-----------------G 498

  Fly   524 ACP--VDCNKQFLIFLAVMCFLKFVGATGRSSNLLLALRCVPSKDKTFSLGFGSMVYSVLAFIPS 586
            .|.  .:|..:...||.:...:.|:.:.......::.||||.|::|:..:|..:....|.|.||:
  Rat   499 LCKKGPECANRLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPA 563

  Fly   587 PIVFGWMLDSYCLVWGK-TCSSKGNCWIYDTKSLRYT---MNLVCASLIFLGSFWNIGVWYHAK- 646
            |:.||.::|..||.||. .|..:|.|.:||..|.|:.   :.:......:|.:|:.:.:....:
  Rat   564 PVYFGALIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMRKFQF 628

  Fly   647 ----DMKVFDEDEKTVQAKQSDDIELKEKP---NDVVTKKK 680
                |....|..|..:..|:|:..::...|   ||...|.|
  Rat   629 PGDIDSSATDHTEMMLGEKESEHTDVHGSPQVENDGELKTK 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	162/612 (26%)
		MFS	55..>410	CDD:119392	101/380 (27%)
		KAZAL_SLC21	447..499	CDD:238650	15/54 (28%)
Slco1a1	NP_058807.1	oat	1..625	CDD:273279	167/645 (26%)
		MFS	40..>408	CDD:119392	106/385 (28%)
		KAZAL_SLC21	436..488	CDD:238650	15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..670		7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920